Development of medial efferent mechanisms in children

儿童内侧传出机制的发育

基本信息

批准号：
10238762
负责人：
Srikanta Mishra
金额：
$ 30.88万
依托单位：
UNIVERSITY OF TEXAS RIO GRANDE VALLEY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-01 至 2022-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10238762
关键词：
12 year old Acoustics Adult Affect Age Algorithms Audiology Auditory Auditory Perception Auditory Threshold Auditory system Biological Biological Assay Brain Stem Child Childhood Clinical Code Communication Complex Contralateral Data Development Device Designs Efferent Pathways Environment Exhibits Feedback Frequencies Goals Hearing Aids Human Intervention Ipsilateral Knowledge Language Development Life Measurement Measures Medial Modeling Noise Noise-Induced Hearing Loss Outcome Outcome Study Peripheral Play Population Predisposition Principal Investigator Public Health Research Role Signal Transduction Speech Speech Perception Stimulus System Techniques Testing Time Work auditory processing base cochlear synaptopathy design developmental plasticity experience improved infancy innovation insight novel relating to nervous system response signal processing sound theories

项目摘要

PROJECT SUMMARY/ ABSTRACT Efferent feedback—a hallmark of peripheral sound coding—plays a critical role in auditory development and plasticity and offers a potential mechanism for minimizing noise-induced cochlear synaptopathy and supra-threshold perceptual deficits. However, our knowledge of how efferent mechanisms develop in humans is extremely limited. The overarching goal of this research is to understand the development of medial efferent mechanisms in humans and their involvement in auditory development. The objective of the proposed project is to systematically investigate the development of the temporal features of efferent effects. Our central hypothesis is that children exhibit developmental changes in efferent effects as a result of developmental plasticity in the brainstem. Our rationale is that detailed knowledge of how efferents work and develop will lead to a better understanding of the role of efferents in auditory development and perceptual deficits. The proposed project has two specific aims: 1) To determine the development of the efferent sensitivity to temporal fluctuations; and 2) To determine the developmental changes in the temporal dynamics of efferent effects. The proposed work is conceptually innovative because it will provide information on the poorly-understood developmental aspects of efferent effects in the children. The approach involves a compelling mix of sweep-tone OAE measurements with advanced signal processing (time- frequency analysis) techniques. The proposed research will provide significant new knowledge regarding how efferents develop in humans, and has implications for (1) for understanding the involvement of efferents in supra-threshold hearing, (2) forming theories of auditory development, (3) developing OAE-based tests of efferent function for predicting susceptibility to noise-induced hearing loss, (4) constructing accurate auditory models, and (5) designing improved hearing device algorithms. The principal investigator is experienced in conducting this kind of research in the current environment. Overall, the proposed project will make a sustained impact on our understanding of the human efferent system and its development, and on the field of pediatric audiology.

项目概要/摘要传出反馈——外围声音编码的标志——在听觉审计中发挥着关键作用发育和可塑性，并提供了一种最小化噪声引起的耳蜗的潜在机制然而，我们对突触病和阈上知觉缺陷的了解还不够。人类开发的机制极其有限。这项研究的总体目标是了解人类内侧传出机制的发展及其参与拟议项目的目标是系统地研究听觉发展。我们的中心假设是儿童的传出效应的时间特征的发展。由于发育可塑性，传出效应表现出发育变化我们的基本原理是，对传出神经如何工作和发育的详细了解将导致更好地理解传出神经在听觉发育和知觉缺陷中的作用。拟议项目有两个具体目标：1）确定传出敏感性的发展时间波动；和 2) 确定时间动态的发展变化拟议的工作在概念上具有创新性，因为它将提供有关传出效应的信息。对儿童传出效应的发展方面知之甚少。涉及扫频 OAE 测量与先进信号处理（时间- 所提出的研究将提供重要的新知识。关于传出神经如何在人类中发育，并且对（1）理解传出神经参与超阈听力，(2) 形成听觉发展理论，(3) 开发基于 OAE 的传出功能测试，用于预测噪声诱发听力的易感性损失，（4）构建准确的听觉模型，以及（5）设计改进的听力设备首席研究员目前在开展此类研究方面经验丰富。总体而言，拟议的项目将对我们对环境的理解产生持续的影响。人类传出系统及其发展，以及儿科听力学领域。