Development of medial efferent mechanisms in children.

儿童内侧传出机制的发展。

• 批准号: 10553566
• 负责人: Srikanta Mishra
• 金额: $ 1.24万
• 依托单位: UNIVERSITY OF TEXAS RIO GRANDE VALLEY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10553566
• 关键词: Algorithms; Audiology; Auditory; Auditory Threshold; Brain Stem; Child; Childhood; Code; Development; Environment; Exhibits; Feedback; Frequencies; Goals; Hearing Aids; Human; Knowledge; Measurement; Medial; Modeling; National Institute on Deafness and Other Communication Disorders; Noise; Noise-Induced Hearing Loss; Parents; Peripheral; Play; Predisposition; Principal Investigator; Research; Role; System; Techniques; Testing; Time; Work; base; cochlear synaptopathy; design; developmental plasticity; experience; improved; innovation; programs; signal processing; sound; theories; undergraduate student

PROJECT SUMMARY/ ABSTRACT (parent R01) Efferent feedback—a hallmark of peripheral sound coding—plays a critical role in auditory development and plasticity and offers a potential mechanism for minimizing noise-induced cochlear synaptopathy and supra-threshold perceptual deficits. However, our knowledge of how efferent mechanisms develop in humans is extremely limited. The overarching goal of this research is to understand the development of medial efferent mechanisms in humans and their involvement in auditory development. The objective of the proposed project is to systematically investigate the development of the temporal features of efferent effects. Our central hypothesis is that children exhibit developmental changes in efferent effects as a result of developmental plasticity in the brainstem. Our rationale is that detailed knowledge of how efferents work and develop will lead to a better understanding of the role of efferents in auditory development and perceptual deficits. The proposed project has two specific aims: 1) To determine the development of the efferent sensitivity to temporal fluctuations; and 2) To determine the developmental changes in the temporal dynamics of efferent effects. The proposed work is conceptually innovative because it will provide information on the poorly-understood developmental aspects of efferent effects in the children. The approach involves a compelling mix of sweep-tone OAE measurements with advanced signal processing (time-frequency analysis) techniques. The proposed research will provide significant new knowledge regarding how efferents develop in humans, and has implications for (1) for understanding the involvement of efferents in supra-threshold hearing, (2) forming theories of auditory development, (3) developing OAE-based tests of efferent function for predicting susceptibility to noise-induced hearing loss, (4) constructing accurate auditory models, and (5) designing improved hearing device algorithms. The principal investigator is experienced in conducting this kind of research in the current environment. Overall, the proposed project will make a sustained impact on our understanding of the human efferent system and its development, and on the field of pediatric audiology.

项目概要/摘要 （母R01） 传出反馈——外围声音编码的标志——在 听觉发展和可塑性，并提供了一种潜在的机制来最小化 噪音引起的耳蜗突触病和阈上知觉缺陷。 我们对人类传出机制如何发展的了解极其有限。 这项研究的总体目标是了解内侧传出神经的发展 人类的机制及其参与听觉发育。 拟议的项目是系统地研究时间的发展 我们的中心假设是儿童表现出发育效应。 由于脑干的发育可塑性而导致传出效应的变化。 基本原理是，详细了解传出神经如何工作和发展将导致更好的 了解传出神经在听觉发育和知觉缺陷中的作用。 拟议项目有两个具体目标： 1) 确定 对时间波动的传出敏感性；以及 2) 确定发育 所提出的工作在概念上是在传出效应的时间动态变化。 创新，因为它将提供有关人们知之甚少的发展的信息 该方法涉及多种令人信服的组合。 具有先进信号处理功能的扫频 OAE 测量（时频 所提出的研究将提供重要的新知识。 关于传出神经如何在人类中发育，并且对理解（1）有影响 传出神经参与超阈听力，（2）形成听觉理论 开发，(3) 开发基于 OAE 的传出功能测试以进行预测 对噪声引起的听力损失的易感性，（4）构建准确的听觉模型， (5) 设计改进的听力设备算法 首席研究员是。 总体而言，在当前环境下开展此类研究具有丰富的经验。 拟议的项目将对我们对人类的理解产生持续的影响 传出系统及其发展，以及儿科听力学领域。