Development of medial efferent mechanisms in children

儿童内侧传出机制的发育

基本信息

批准号：
10331220
负责人：
Srikanta Mishra
金额：
$ 9.21万
依托单位：
UNIVERSITY OF TEXAS RIO GRANDE VALLEY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-01 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10331220
关键词：
Address Affect Algorithms Amplifiers Audiology Auditory Auditory Threshold Auditory system Biological Biological Assay Brain Stem Characteristics Child Childhood Clinical Clinical Research Cochlea Code Comparative Study Development Efferent Pathways Environment Exhibits External auditory canal Feedback Female Frequencies Gender Goals Health Health Sciences Hearing Hearing Aids Hispanics Human Intervention Knowledge Light Measurement Measures Medial Methodology Methods Modeling Monitor Noise Noise-Induced Hearing Loss Organ Outcome Parents Peripheral Phase Physiological Physiology Play Predisposition Principal Investigator Process Property Research Research Design Role Sample Size Sex Differences Stimulus Strategic Planning System Techniques Testing Time Underrepresented Populations United States National Institutes of Health Woman Women&apos s Health Work base cochlear synaptopathy design developmental plasticity experience experimental study hearing impairment improved innovation male men microphone middle ear normal hearing otoacoustic emission recruit response sex signal processing sound theories

项目摘要

PROJECT SUMMARY/ ABSTRACT (parent R01) Efferent feedback—a hallmark of peripheral sound coding—plays a critical role in auditory development and plasticity and offers a potential mechanism for minimizing noise-induced cochlear synaptopathy and supra-threshold perceptual deficits. However, our knowledge of how efferent mechanisms develop in humans is extremely limited. The overarching goal of this research is to understand the development of medial efferent mechanisms in humans and their involvement in auditory development. The objective of the proposed project is to systematically investigate the development of the temporal features of efferent effects. Our central hypothesis is that children exhibit developmental changes in efferent effects as a result of developmental plasticity in the brainstem. Our rationale is that detailed knowledge of how efferents work and develop will lead to a better understanding of the role of efferents in auditory development and perceptual deficits. The proposed project has two specific aims: 1) To determine the development of the efferent sensitivity to temporal fluctuations; and 2) To determine the developmental changes in the temporal dynamics of efferent effects. The proposed work is conceptually innovative because it will provide information on the poorly- understood developmental aspects of efferent effects in the children. The approach involves a compelling mix of sweep-tone OAE measurements with advanced signal processing (time-frequency analysis) techniques. The proposed research will provide significant new knowledge regarding how efferents develop in humans, and has implications for (1) for understanding the involvement of efferents in supra-threshold hearing, (2) forming theories of auditory development, (3) developing OAE-based tests of efferent function for predicting susceptibility to noise-induced hearing loss, (4) constructing accurate auditory models, and (5) designing improved hearing device algorithms. The principal investigator is experienced in conducting this kind of research in the current environment. Overall, the proposed project will make a sustained impact on our understanding of the human efferent system and its development, and on the field of pediatric audiology.

项目概要/摘要（母R01）传出反馈——外围声音编码的标志——在听觉发展和可塑性，并提供了一种潜在的机制来最小化噪音引起的耳蜗突触病和阈上知觉缺陷。我们对人类传出机制如何发展的了解极其有限。本研究的总体目标是了解医学的发展人类的传出机制及其参与听觉发育。拟议项目的目标是系统地调查该领域的发展我们的中心假设是儿童表现出传出效应的时间特征。由于发育可塑性而导致传出效应的发育变化我们的基本原理是对传出神经如何工作和发展的详细了解。将有助于更好地理解传出神经在听觉发育中的作用拟议的项目有两个具体目标：1）确定发展对时间波动的传出敏感性；以及 2) 确定传出效应的时间动态的发展变化。这项工作在概念上具有创新性，因为它将提供有关贫困人口的信息了解儿童传出效应的发展方面。涉及扫频 OAE 测量与高级信号的引人注目的组合拟议的研究将提供处理（时频分析）技术。关于人类传出神经如何发育的重要新知识 (1) 对于理解传出神经参与超阈值的影响听力，(2) 形成听觉发展理论，(3) 开发基于 OAE 的测试预测噪声性听力损失易感性的传出功能，(4) 构建准确的听觉模型，以及（5）设计改进的听力设备首席研究员在进行此类研究方面经验丰富。总体而言，拟议项目将产生持续影响。我们对人类传出系统及其发展的理解，以及小儿听力学领域。