In vivo Evaluation of Lymph Nodes Using Quantitative Ultrasound

使用定量超声对淋巴结进行体内评估

• 批准号: 10737152
• 负责人: JONATHAN MAMOU
• 金额: $ 73.59万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-02 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10737152
• 关键词: Acoustics; Address; Affect; Algorithms; Anxiety; Area; Benign; Biopsy; Classification; Clinical; Collaborations; Cytology; Data; Detection; Discriminant Analysis; Disease; Disease Management; Disseminated Malignant Neoplasm; Evaluation; Excision; Fine needle aspiration biopsy; Foundations; Image; Lead; Light Microscope; Lymph Node Tissue; Lymphoma; Magnetic Resonance; Medical; Medicine; Metastatic Neoplasm to Lymph Nodes; Methods; Micrometastasis; Microscopic; Modeling; Neoplasm Metastasis; New York; Nonmetastatic; Operating Rooms; Operative Surgical Procedures; Outcome; Pathologist; Patient Recruitments; Patients; Performance; Procedures; Process; Property; Prostate; ROC Curve; Research; Research Personnel; Research Project Grants; Risk; Signal Transduction; Slice; Slide; Specimen; Staging; Surgical Pathology; System; Testing; Thyroid Gland; Time; Tissues; Ultrasonics; Universities; Validation; artificial neural network; attenuation; cost; data acquisition; electric impedance; improved; in vivo; in vivo evaluation; instrument; instrumentation; laptop; lymph node biopsy; lymph nodes; patient population; personalized care; quantitative ultrasound; side effect; standard of care; statistics; support vector machine; synergism; time use; tool; treatment planning; ultrasound; virtual

Project Summary This application proposes a collaborative study to be performed by Weill Cornell Medicine (WCM) in New York, NY, as the lead organization in collaboration with GE Research (GER) in Niskayuna, NY, and Stony Brook Medicine (SBM) affiliated with the State University of New York in Stony Brook, NY. The proposed project addresses the need for reliable, highly sensitive means of detecting metastases to lymph nodes (LNs) and distinguishing them from primary lymphomas and LNs affected by benign conditions. This capability will allow improved staging and treatment of disease. Accordingly, we seek to validate existing encouraging results obtained in prior studies by WCM and SBM using quantitative-ultrasound (QUS) methods to detect metastases in LNs by applying and evaluating these promising methods using a modified clinical scanner to acquire ultrasonic echo-signal data from patients undergoing medically required ultrasonically guided fine-needle aspirations (FNAs) of suspicious LNs. The study will include a far broader range of disease types from a larger and more-diverse patient population than has been possible in studies to date. Validation efforts will develop, deploy, and validate an application for QUS- based detection and characterization of LNs implemented in a clinical scanner. Successful validation will establish a foundation for incorporation of QUS-based methods for LN evaluation into clinical ultrasonic scanners. Such instruments will be able to evaluate suspicious LNs intra-operatively in the operating room or pre-operatively in the examination room. The collaborating researchers will synergize capabilities in the following general ways: WCM will provide project oversight and coordination and will apply, refine, and test QUS and classification methods; GER will provide ultrasound instrumentation and will develop and validate the QUS application for the scanner; SBM will recruit patients and acquire ultrasonic and cytopathological data from patients undergoing FNAs of their LNs.

项目概要 本申请提议由威尔康奈尔医学 (WCM) 在新州开展一项合作研究 纽约州约克作为牵头组织与位于纽约州尼斯卡尤纳和斯托尼的 GE Research (GER) 合作 布鲁克医学 (SBM) 隶属于纽约州立大学，位于纽约州石溪。拟议的 该项目满足了对可靠、高度灵敏的淋巴结转移检测方法的需求 (LN) 并将其与原发性淋巴瘤和受良性疾病影响的 LN 区分开来。这 能力将有助于改善疾病的分期和治疗。因此，我们寻求验证现有的 WCM 和 SBM 使用定量超声 (QUS) 进行的先前研究取得了令人鼓舞的结果 通过应用和评估这些有前途的方法来检测淋巴结转移的方法 改进的临床扫描仪，用于从接受治疗的患者那里获取超声波回波信号数据 需要超声引导下对可疑淋巴结进行细针抽吸（FNA）。该研究将包括 与以前相比，来自更大、更多样化的患者群体的疾病类型范围更广 迄今为止的研究是可能的。验证工作将开发、部署和验证 QUS-的应用程序 在临床扫描仪中实现基于 LN 的检测和表征。成功验证将 为将基于 QUS 的 LN 评估方法纳入临床超声奠定基础 扫描仪。此类仪器将能够在手术室中评估可疑的淋巴结 或术前在检查室进行。合作研究人员将协同各个领域的能力 以下一般方式：WCM 将提供项目监督和协调，并将应用、完善和测试 QUS 和分类方法； GER 将提供超声波仪器并将开发和 验证扫描仪的 QUS 应用程序； SBM 将招募患者并获取超声波和 接受 LN 细针穿刺活检的患者的细胞病理学数据。