Image-Guided Cochlear Implant Programming: Pediatric Speech, Language, and Literacy

图像引导人工耳蜗编程：儿科言语、语言和读写能力

基本信息

批准号：
9765569
负责人：
Stephen Mark Camarata
金额：
$ 46.28万
依托单位：
VANDERBILT UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-04-01 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9765569
关键词：
12 year old Acoustics Adult Articulation Auditory Auditory system Child Childhood Clinical Clinical Trials Design Cochlear Implants Complex Control Groups Development Distal Double-Blind Method Early Intervention Electric Stimulation Electrodes Enrollment Generations Goals Growth Interdisciplinary Study Intervention Language Language Disorders Literature Location Measures Mediating Mediator of activation protein Modeling Monitor Noise Outcome Participant Patients Procedures Production Psychophysics Randomized Randomized Clinical Trials Randomized Controlled Clinical Trials Reading Regression Analysis Research Research Activity Research Design Resolution Sampling Short-Term Memory Signal Transduction Speech Speech Disorders Standardization Technology Testing Time Waiting Lists aged auditory deprivation auditory processing hearing impairment image guided implantation improved improved outcome literacy normal hearing peer phonological awareness phonology reading ability reading comprehension reading difficulties signal processing skills speech recognition temporal measurement

项目摘要

PROJECT SUMMARY Although the recent literature has indicated that children receiving cochlear implants (CIs) often have dramatically improved speech and language ability relative to previous generations of children with hearing loss, many pediatric CI recipients display persistent speech and language disorders despite early implantation and associated speech/language intervention. There is a striking paucity and ongoing need for studies that systematically examine the relationship between intracochlear electrode location, audiological profile, and subsequent phonological awareness, speech, language, and literacy in pediatric CI recipients. This project provides a unique opportunity to examine whether individualized, image-guided CI programming (IGCIP) significantly improves outcomes in pediatric CI patients. The proposed research activities will examine the impact of personalized IGCIP in pediatric CI recipients on measures of basic auditory function (spectral, temporal, and spectrotemporal resolution), word and non-word recognition, speech production, language, phonological awareness, and reading comprehension using a double blind, waitlist control randomized clinical trial (RCT) design. A total sample of 72 children with CIs aged six to twelve years old will be enrolled in the project: half (n = 36) will be randomized to an immediate IGCIP condition and half to a waitlist control condition. The waitlisted participants (n = 36) will undergo IGCIP after 12 months of monitoring and then followed for an additional 12 months after intervention (total time in the study for both groups: 24 months). Those immediately provided with IGCIP will also be followed for a total of 24 months. All participants will undergo extensive audiological assessment as well as tests of phonological awareness, speech, language, and literacy at baseline as well as at regular intervals: 2, 6, 12, 14, 18, and 24 months. We will use predictor analyses to determine the impact of immediate and deferred IGCIP on subsequent auditory, speech, language, and literacy outcomes.

项目概要尽管最近的文献表明接受人工耳蜗植入 (CI) 的儿童通常会出现与前几代有听力的儿童相比，言语和语言能力显着提高尽管早期植入，但许多儿科 CI 接受者仍表现出持续的言语和语言障碍以及相关的言语/语言干预。对于以下方面的研究极为缺乏且持续存在需求：系统地检查耳蜗内电极位置、听力学特征和儿科 CI 接受者随后的语音意识、言语、语言和读写能力。这个项目提供了一个独特的机会来检查是否个性化、图像引导 CI 编程 (IGCIP) 显着改善儿科 CI 患者的预后。拟议的研究活动将审查个性化 IGCIP 对儿科 CI 接受者的基本听觉功能（频谱、听觉功能）测量的影响时间和频谱时间分辨率）、单词和非单词识别、语音生成、语言、使用双盲、候补名单控制随机临床的语音意识和阅读理解试验（RCT）设计。总共 72 名 6 至 12 岁 CI 儿童样本将被纳入该研究项目：一半（n = 36）将被随机分配到即时 IGCIP 条件，一半分配到候补名单控制条件。列入候补名单的参与者 (n = 36) 将在 12 个月的监测后接受 IGCIP，然后进行跟踪干预后额外 12 个月（两组研究总时间：24 个月）。那些立即 IGCIP 提供的信息也将被跟踪总共 24 个月。所有参与者都将接受广泛的听力学评估以及语音意识、言语、语言和读写能力测试基线以及定期间隔：2、6、12、14、18 和 24 个月。我们将使用预测分析来确定立即和延迟的 IGCIP 对随后的听觉、言语、语言和读写能力的影响结果。