Admin Core

管理核心

• 批准号: 10657441
• 负责人: Hashem B El-Serag
• 金额: $ 16.62万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10657441
• 关键词: Administrator; Advisory Committees; Award; Biochemical Markers; Cancer Biology; Cancer Center; Center for Translational Science Activities; Chemoprevention; Communication; Computer software; Data; Dedications; Department chair; Diabetes Mellitus; Electronics; Ensure; Epidemiology; Focus Groups; Functional disorder; Funding; Gastroenterology; General Hospitals; Genetic Markers; Goals; Hepatology; Hospitals; Human Resources; Individual; Information Dissemination; Infrastructure; Institution; Leadership; Liver diseases; Malignant neoplasm of liver; Massachusetts; Medicine; Metabolic; Metabolic dysfunction; Metabolic syndrome; Methods; Mission; Monitor; Obesity; Occupational activity of managing finances; Online Systems; Pennsylvania; Performance; Policies; Prevention; Prevention strategy; Primary carcinoma of the liver cells; Program Evaluation; Protocols documentation; Qualifying; Research; Research Institute; Research Personnel; Research Project Grants; Resource Sharing; Resources; Risk Factors; Risk Reduction; Running; Science; Services; Structure; System; Technology; Texas; Time; United States National Institutes of Health; Universities; Woman; anticancer research; biomarker development; cancer prevention; college; conflict resolution; dashboard; experience; fatty liver disease; medical schools; meetings; mortality; multidisciplinary; operation; phenotypic biomarker; process optimization; professor; programs; success; symposium; synergism; timeline; web based software; web site; webinar

ABSTRACT—Administrative Core The goal of the Program Project is to reduce the burden of hepatocellular carcinoma (HCC)-related mortality through better understanding of contemporary risk factors (e.g., phenotypic, biochemical and genetic markers of metabolic dysfunction) and preventive strategies (e.g., chemoprevention) of HCC related to metabolic (dysfunction) associated fatty liver disease (MAFLD). To accomplish this goal, we propose 3 Projects, 2 shared resource Cores: Biospecimen and Biomarker Development Core and Data and Analysis Core, and the Administrative Core. The Administrative Core will govern the Program, run the finances and operations, coordinate between groups, and support the Program Project. We propose a well-run Administrative Core with strong and experienced leadership that will be essential to the success of the Program Project and the studies and cores it supports. Dr. Hashem El-Serag, Chair of the Department of Medicine at Baylor College of Medicine, Houston will be the Director of the Administrative Core. Dr. Fasiha Kanwal, Section Chief of Gastroenterology and Hepatology at Baylor College of Medicine will be the Associate Director. Both are highly experienced running Centers and Cores. One Program Project administrator will provide the necessary support for day-to-day financial management and operations. An Executive Committee and an External Advisory Committee will perform oversight. The Executive Committee will be composed of the Director, Associate Director, Core Directors, and Project Leaders who will meet monthly. The External Advisory Committee will comprise of 4 external experts in liver cancer biology, epidemiology, prevention as well as coordinating center activities. The Aims of the Administrative Core are: (1) to build a Core with strong leadership to manage the Program Project; (2) to use optimized methods for managing the Program’s scientific, regulatory, and financial functions; and (3) to support coordination and communication between Program investigators and outside advisors and collaborators. The Administrative Core will provide centralized administrative and scientific leadership to facilitate synergistic interactions among all components of the Program Project. The core will provide a platform for monthly meeting for the PIs of all projects and cores to meet and share progress and results and troubleshoot problems. The Administrative Core will tracking progress of Projects and Cores against timelines and milestones via accessible real-time electronic dashboards and evaluating performance of Projects, Cores, and the overall Program. The Administrative Core will also implement a web-based software to track service use and conduct webinars, meetings, and conferences. The Executive Committee of the Administrative Core will also provide platform for investigators to influence the operations of the Program Project.

摘要 - 管理核心 该计划项目的目标是减少肝细胞癌（HCC）相关的死亡率 通过更好地了解当代危险因素（例如，表型，生化和遗传标志物的 与代谢相关的HCC的代谢功能障碍）和预防策略（例如化学预防） （功能障碍）相关脂肪肝病（MAFLD）。为了实现这一目标，我们提出了3个项目，共享2个项目 资源核心：生物循环和生物标志物发展核心以及数据和分析核心，以及 行政核心。行政核心将管理该计划，运行财务和运营， 组之间的协调，并支持计划项目。 我们提出了一个运行良好的行政核心，具有强大而经验丰富的领导才能对 计划项目的成功及其支持的研究和核心。 Hashem El-Serag博士，主席 休斯顿贝勒医学院医学系将担任行政核心主任。 贝勒医学院的胃肠病学和肝病学部长Fasiha Kanwal博士将是 副主任。两者都是经验丰富的跑步中心和核心。一个计划项目管理员 将为日常财务管理和运营提供必要的支持。执行委员会 外部咨询委员会将进行监督。执行委员会将由 董事，副主任，核心董事和项目负责人将每月开会。外部咨询 委员会将完成4位肝癌生物学，流行病学，预防以及预防的外部专家 协调中心活动。 行政核心的目的是：（1）建立具有强大领导力的核心来管理该计划 项目; （2）使用优化的方法来管理该计划的科学，法规和财务职能； （3）支持计划调查员与外部顾问之间的协调和沟通以及 合作者。行政核心将提供集中的行政和科学领导才能促进 程序项目的所有组件之间的协同互动。核心将为 所有项目和核心的PI每月会议，以满足和分享进度和结果并进行故障排除 问题。行政核心将跟踪针对时间表和里程碑的项目和核心的进度 通过可访问的实时电子仪表板并评估项目，核心的性能和整体 程序。管理核心还将实施基于网络的软件，以跟踪服务使用和进行操作 网络研讨会，会议和会议。行政核心执行委员会还将提供 调查人员影响计划项目的运营的平台。