MOSAIC: Administrative Core

MOSAIC：行政核心

• 批准号: 10729421
• 负责人: Kristin R Swanson
• 金额: $ 20.86万
• 依托单位: MAYO CLINIC ARIZONA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-18 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10729421
• 关键词: Administrator; Advisory Committees; Area; Authorization documentation; Award; Biopsy; Businesses; Collaborations; Communication; Communities; Core Biopsy; Data; Discipline; Educational workshop; Ensure; Evaluation; Faculty; Feedback; Funding; Glioma; Grant; Growth; Image; Institution; Institutional Review Boards; Leadership; Logistics; Machine Learning; Magnetic Resonance Imaging; Malignant Neoplasms; Mathematics; Monitor; Office of Administrative Management; Oncology; Pathology; Patients; Phenotype; Pilot Projects; Process; Publications; Radiology Specialty; Regulation; Reproducibility; Research Project Grants; Resource Sharing; Resources; Suggestion; Systems Analysis; Systems Biology; Tissues; Visit; Work; authority; career; clinical imaging; data access; data exchange; data integration; data management; data sharing; imaging facilities; interest; meetings; neuro-oncology; outreach; programs; recruit; symposium; training opportunity; web site

SUMMARY: ADMINISTRATIVE CORE The overarching objective for the Mayo/Columbia MOSAIC CSBC is to build a conceptual framework to understand tissue state transitions that happen in glioma and the ways to interpret magnetic resonance imaging (MRI) relative to those changes for these key cellular phenotypes. Achieving this objective will require a multi- faceted approach reflected by the multiple projects and cores being proposed. The administrative core will be the primary touchpoint for all pieces of the proposal, overseeing that work is done in an efficient way and providing the necessary administrative support to coordinate all efforts. The central work for our CSBC revolves around extensive analysis of image-localized biopsies that are collected, processed, and stored by Biospecimen Core, analyzed by the Data Integration and Computation Core, and shared between Projects 1 and 2. This highly integrated analysis of image-localized biopsies from GBM patients with clinical imaging will be actively managed by the Administrative Core to ensure a smooth experimental flow with an emphasis on quality and reproducibility. We envision that MOSAIC will serve as a nexus for collaborations focused on the topics revolving around tissue state transitions and clinical imaging across the consortium with likely areas of interest in other cancers beyond glioma. A key function of the Administrative Core will be to actively cultivate such collaborations through coordination with our Outreach Core, particularly through administering Intra-Center and Cross-Consortium Pilot Projects, hosting workshops and symposiums, and facilitating visiting faculty all while enhancing diverse perspectives on this critical topic. These activities will extend both to collaborations between institutions involved in the Mayo/Columbia CSBC and collaborations across the U54 and U01 holders within the CSBC and PSON networks. In the Administrative Core, our aims—to manage center logistics and communication, administer Intra-Center Pilot Projects, and create and support the External Advisory Committee—will support all aspects of our application. Co-PDs Swanson and Canoll will provide the central leadership in the Administrative Core, while the Center Program Administrator will provide day-to-day business, administrative and scientific management of Center activities.

摘要：行政核心 蛋黄酱/哥伦比亚马赛克CSBC的总体目标是建立一个概念框架 了解神经胶质瘤中发生的组织状态转变以及解释磁共振成像的方法 （MRI）相对于这些关键细胞表型的这些变化。实现这一目标将需要多个 提出的多个项目和核心反映了刻面方法。行政核心将是 提案的所有部分的主要接触点，监督工作是以有效的方式完成的 提供必要的行政支持以协调所有努力。我们CSBC旋转的中心工作 围绕收集，加工和存储生物仿生的图像定位活检的广泛分析 核心，通过数据集成和计算核心分析，并在项目1和2之间共享。 来自临床成像的GBM患者的图像 - 定位活检的高度综合分析将是积极的 由行政核心管理以确保平稳的实验流，重点是质量和 可重复性。 我们设想，马赛克将成为关注组织围绕围绕组织的主题的合作的联系 整个财团的国家过渡和临床成像，可能在其他癌症中引起关注的领域 神经胶质瘤。行政核心的关键功能将是通过 与我们的外展核心协调，尤其是通过管理中心和跨核管飞行员 项目，举办研讨会和专题讨论会以及支持参观教师的同时增强潜水员 对这个关键主题的观点。这些活动将扩展到相关机构之间的合作 在Mayo/Columbia CSBC中，以及CSBC和PSON中U54和U01持有人的合作 网络。 在行政核心中，我们的目标 - 管理中心登录和沟通，管理中心 试点项目，并建立和支持外部咨询委员会 - 将支持我们的各个方面 应用。 Co-PDS Swanson和Canoll将在行政核心中提供中央领导，而 中心计划管理员将提供日常业务，行政和科学管理 中心活动。