Admin Core

管理核心

基本信息

批准号：
10410753
负责人：
Hashem B El-Serag
金额：
$ 16.69万
依托单位：
BAYLOR COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-07-01 至 2027-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10410753
关键词：
Administrator Advisory Committees Award Biochemical Markers Cancer Biology Cancer Center Center for Translational Science Activities Chemoprevention Communication Computer software Data Analyses Department chair Diabetes Mellitus Ensure Epidemiology Focus Groups Funding Gastroenterology General Hospitals Genetic Markers Goals Hepatology Hospitals Human Resources Individual Information Dissemination Infrastructure Institution Leadership Liver diseases Malignant neoplasm of liver Massachusetts Medicine Metabolic dysfunction Metabolic syndrome Methods Mission Monitor Obesity Occupational activity of managing finances Online Systems Pennsylvania Performance Policies Prevention Prevention strategy Primary carcinoma of the liver cells Program Evaluation Protocols documentation Research Research Institute Research Personnel Research Project Grants Resource Sharing Resources Risk Risk Factors Running Science Services Structure System Technology Texas Time TimeLine United States National Institutes of Health Universities Woman biomarker development cancer prevention college conflict resolution dashboard experience fatty liver disease medical schools meetings metabolic-associated fatty liver disease mortality multidisciplinary operation phenotypic biomarker process optimization professor programs success symposium synergism web site webinar

项目摘要

ABSTRACT—Administrative Core The goal of the Program Project is to reduce the burden of hepatocellular carcinoma (HCC)-related mortality through better understanding of contemporary risk factors (e.g., phenotypic, biochemical and genetic markers of metabolic dysfunction) and preventive strategies (e.g., chemoprevention) of HCC related to metabolic (dysfunction) associated fatty liver disease (MAFLD). To accomplish this goal, we propose 3 Projects, 2 shared resource Cores: Biospecimen and Biomarker Development Core and Data and Analysis Core, and the Administrative Core. The Administrative Core will govern the Program, run the finances and operations, coordinate between groups, and support the Program Project. We propose a well-run Administrative Core with strong and experienced leadership that will be essential to the success of the Program Project and the studies and cores it supports. Dr. Hashem El-Serag, Chair of the Department of Medicine at Baylor College of Medicine, Houston will be the Director of the Administrative Core. Dr. Fasiha Kanwal, Section Chief of Gastroenterology and Hepatology at Baylor College of Medicine will be the Associate Director. Both are highly experienced running Centers and Cores. One Program Project administrator will provide the necessary support for day-to-day financial management and operations. An Executive Committee and an External Advisory Committee will perform oversight. The Executive Committee will be composed of the Director, Associate Director, Core Directors, and Project Leaders who will meet monthly. The External Advisory Committee will comprise of 4 external experts in liver cancer biology, epidemiology, prevention as well as coordinating center activities. The Aims of the Administrative Core are: (1) to build a Core with strong leadership to manage the Program Project; (2) to use optimized methods for managing the Program’s scientific, regulatory, and financial functions; and (3) to support coordination and communication between Program investigators and outside advisors and collaborators. The Administrative Core will provide centralized administrative and scientific leadership to facilitate synergistic interactions among all components of the Program Project. The core will provide a platform for monthly meeting for the PIs of all projects and cores to meet and share progress and results and troubleshoot problems. The Administrative Core will tracking progress of Projects and Cores against timelines and milestones via accessible real-time electronic dashboards and evaluating performance of Projects, Cores, and the overall Program. The Administrative Core will also implement a web-based software to track service use and conduct webinars, meetings, and conferences. The Executive Committee of the Administrative Core will also provide platform for investigators to influence the operations of the Program Project.

摘要—行政核心该计划项目的目标是减轻肝细胞癌 (HCC) 相关死亡率的负担通过更好地了解当代风险因素（例如，表型、生化和遗传标记）代谢功能障碍）以及与代谢相关的 HCC 的预防策略（例如化学预防）为了实现这一目标，我们提出了 3 个项目，其中 2 个是共享的。资源核心：生物样本和生物标志物开发核心以及数据和分析核心，以及行政核心。行政核心将管理该计划、管理财务和运营，协调小组之间的关系，并支持计划项目。我们建议建立一个运行良好的行政核心，并配备强大且经验丰富的领导层，这对于该计划项目及其支持的研究和核心的成功。休斯顿贝勒医学院医学系将担任行政核心主任。贝勒医学院胃肠病学和肝病科主任 Fasiha Kanwal 博士将担任两位副总监都是经验丰富的中心和核心项目管理员。将为日常财务管理和运营提供必要的支持。外部咨询委员会将进行监督。执行委员会将由以下人员组成。董事、副董事、核心董事和项目负责人每月举行一次会议。委员会将由 4 名肝癌生物学、流行病学、预防以及肝癌领域的外部专家组成。协调中心活动。行政核心的目标是： (1) 建立一个具有强有力领导的核心来管理该计划 (2) 使用优化方法来管理本计划的科学、监管和财务职能； (3) 支持项目研究者和外部顾问之间的协调和沟通行政核心将提供集中的行政和科学领导，以促进合作。该项目的所有组成部分之间的协同互动将提供一个平台。所有项目和核心的 PI 每月举行一次会议，以会面并分享进展和结果并解决问题管理核心将根据时间表和里程碑跟踪项目和核心的进度。通过可访问的实时电子仪表板并评估项目、核心和整体的绩效管理核心还将实施一个基于网络的软件来跟踪服务的使用和执行。行政核心执行委员会还将提供网络研讨会、会议和大会。为调查人员影响计划项目运作的平台。