Synthetic Biology and Biotechnology (SB2) Predoctoral Training Program

合成生物学与生物技术（SB2）博士前培训项目

• 批准号: 10654551
• 负责人: CHRISTOPHER S CHEN
• 金额: $ 22.98万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10654551
• 关键词: Biotechnology; Training Programs; pre-doctoral; synthetic biology

Project Summary/Abstract This application seeks funding for a Biotechnology Predoctoral Training Program in Synthetic Biology at Boston University. Three predoctoral training slots per year are requested, to support trainees for their second and third years of residence. The Synthetic Biology and Biotechnology (SB2) Program aims to prepare top researchers for careers in synthetic biology. Synthetic biology uses engineering approaches to build complex biological systems for research and applications, ranging from industrial chemistry to medical breakthroughs. This fast-growing discipline has the potential to revolutionize many scientific fields and industries, including biotechnology, and our program will be the first in the nation to prepare students specifically in synthetic biology. An intrinsically interdisciplinary field, our program integrates (a) solid technical foundation in the principles and practices of synthetic biology, (b) hands-on exposure to biotech research and the principles of commercialization for translating new synthetic biology technologies, (c) and extensive professional skills development, including teamwork and communication, necessary to success in interdisciplinary teams. The curriculum includes a strong didactic foundation in molecular and cellular engineering, the theory and practice of synthetic biology, data analysis, and basic understanding of commercialization and industrial research goals, along with in-depth examination of a broad range of potential applications. Experiential learning is emphasized throughout the curriculum. Program features include (1) summer internship in a local biotech company, (2) Synthetic Biology Laboratory to introduce state-of-the-art techniques and data analysis methodologies, (3) rigorous dissection of literature focusing on critical thinking and experimental design and validation, (4) a 5-day intensive training course in Biotechnology Entrepreneurship, (5) an SB2 Annual Seminar and Poster Day at which trainees present their research. Emphasis is placed throughout in developing skills in reproducible and rigorous research, in communicating science, and in understanding how to apply synthetic biology to find new solutions to existing problems in academia and biotechnology. Numerous mechanisms are employed to assist trainees in preparing for diverse career paths with formal and informal opportunities to interact with scientists from a range of careers. A distinguished training faculty of 20 mentors is drawn from various departments and colleges at Boston University, with expertise in engineering, biology, chemistry, pharmacology, computer engineering, and physics. All students have a primary and secondary advisor, one focused on foundational tools and one on applications, to ensure their research is clearly motivated and far-reaching. Students play critical roles in defining their interdisciplinary research projects by developing a formal Individual Development Plan.

项目摘要/摘要 该申请寻求资助合成生物学的生物技术训练计划 在波士顿大学。要求每年三个术前训练插槽，以支持受训者 他们的第二年和第三年。合成生物学和生物技术（SB2）计划 旨在为顶级研究人员准备合成生物学的职业。合成生物学使用工程 为研究和应用构建复杂生物系统的方法，从工业 化学对医学突破。这种快速增长的学科有可能革新 许多科学领域和行业，包括生物技术，我们的计划将是第一个 民族为专门为合成生物学做好准备。本质上的跨学科领域，我们的 计划在合成生物学的原理和实践中整合（a）扎实的技术基础， （b）动手接触生物技术研究和翻译新的商业化原则 合成生物学技术（C）和广泛的专业技能开发，包括团队合作 和沟通，这是跨学科团队成功所必需的。课程包括 分子和细胞工程中的强大教学基础，合成的理论和实践 生物学，数据分析以及对商业化和工业研究目标的基本理解， 深入研究广泛的潜在应用。体验学习是 在整个课程中强调。计划功能包括（1）本地暑期实习 生物技术公司（2）合成生物学实验室介绍最先进的技术和数据 分析方法，（3）对批判性思维和 实验设计和验证，（4）为期5天的生物技术培训课程 企业家精神，（5）SB2年度研讨会和海报日，学员们展示了他们的 研究。重点是发展可再现和严格研究的技能， 交流科学，并了解如何应用合成生物学以找到新的解决方案 学术界和生物技术的现有问题。采用了许多机制来协助 受训者在准备各种职业道路上，并有正式和非正式的机会与 来自一系列职业的科学家。来自20名导师的杰出培训学院 波士顿大学的各个系和学院，具有工程，生物学专业知识， 化学，药理学，计算机工程和物理学。所有学生都有小学 二级顾问（专注于基础工具，以及应用程序），以确保其 研究显然是动机和深远的。学生在定义自己的 跨学科研究项目通过制定正式的个人发展计划。

项目成果

Long-term evolution of proliferating cells using the eVOLVER platform.

使用 eVOLVER 平台进行增殖细胞的长期进化。

• DOI: 10.1101/2023.03.28.534552
• 发表时间: 2023
• 期刊: bioRxiv : the preprint server for biology
• 作者: García-Ruano,Daniel;Jain,Akanksha;Heins,ZacharyJ;Wong,BrandonG;YimerWolle,Ezira;Khalil,AhmadS;Coudreuse,Damien
• 通讯作者: Coudreuse,Damien

Scaffold proteins as dynamic integrators of biological processes.

• DOI: 10.1016/j.jbc.2022.102628
• 发表时间: 2022-12
• 期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
• 影响因子: 4.8
• 作者: DiRusso, Christopher J.;Dashtiahangar, Maryam;Gilmore, Thomas D.
• 通讯作者: Gilmore, Thomas D.