Trimetaspheres Novel MRI Dynamic Contrast Agents

Trimetaspheres 新型 MRI 动态造影剂

• 批准号: 6831985
• 负责人: MICHAEL J DANILICH
• 金额: $ 19.59万
• 依托单位: LUNA INNOVATIONS, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-22 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6831985
• 关键词: bioimaging /biomedical imaging; biotechnology; chemical property; chemical structure function; contrast media; ethylene glycols; gadolinium; image enhancement; laboratory mouse; magnetic resonance imaging; nanomedicine; neoplasm /cancer blood supply; pharmacology; technology /technique development

DESCRIPTION (provided by applicant): This proposal addresses the need to develop a new class of magnetic resonance (MR) contrast agents, Trimetaspheres for dynamic contrast MR imaging in small animal studies. Dynamic contrast focuses on the use of contrast agents of different molecular sizes having different abilities to penetrate into tumor and normal tissue. Such contrast agents can be used to highlight differences between normal and abnormal tissue, highlight the vascular supply of tumor tissue, and may have important prognostic implications for tumor growth, metastatic potential and aggressiveness. Luna Innovations will manufacture an appropriate Trimetasphere nanomaterial (such as Gd3N@C80) and functionalize it with polyethylene glycol of different molecular sizes to obtain preliminary data to assess the ability of these novel nanomaterials as potential dynamic contrast agents. Preliminary studies using normal mice will be pursued in a 4.7T MR scanner specially designed for small animal imaging through our collaborators in the Biomedical MR Laboratory at Washington University. Key issues to be characterized in vivo include how fast the agent remains in the blood stream, how fast it penetrates into normal tissues, and how soon it is excreted through the kidneys. Phase I results will establish a baseline to study a metastatic cancer model in Phase II.

描述（由申请人提供）： 该提案解决了开发一类新型磁共振 (MR) 造影剂 Trimetaspheres 的需求，用于小动物研究中的动态对比 MR 成像。动态造影侧重于使用具有不同渗透肿瘤和正常组织能力的不同分子大小的造影剂。此类造影剂可用于突出正常组织和异常组织之间的差异，突出肿瘤组织的血管供应，并且可能对肿瘤生长、转移潜力和侵袭性具有重要的预后意义。 Luna Innovations 将制造合适的 Trimetasphere 纳米材料（例如 Gd3N@C80），并用不同分子大小的聚乙二醇对其进行功能化，以获得初步数据来评估这些新型纳米材料作为潜在动态造影剂的能力。我们将在华盛顿大学生物医学 MR 实验室的合作者专门设计用于小动物成像的 4.7T MR 扫描仪中进行使用正常小鼠的初步研究。体内需要表征的关键问题包括药物在血流中的保留速度、渗透到正常组织的速度以及通过肾脏排泄的速度。第一阶段的结果将为第二阶段研究转移性癌症模型建立基线。