Novel Chitosan Mucoadhesives

新型壳聚糖粘膜粘合剂

• 批准号: 6934981
• 负责人: MICHAEL J DANILICH
• 金额: $ 13.2万
• 依托单位: LUNA INNOVATIONS, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6934981
• 关键词: acetylation; adhesions; biodegradable product; biomaterial compatibility; biomaterial development /preparation; chitin; crosslink; cytotoxicity; hemostatics; lysozyme; molecular weight; polymers; protein degradation; surface property; surgery material /equipment; wound healing

DESCRIPTION (provided by applicant): There have been numerous approaches to developing soft tissue adhesives that combine tissue compatibility, ease of use, good adhesive and cohesive strength, hemostasis and promotion of wound healing. These include completely synthetic approaches and approaches based on or utilizing natural compounds. Despite the significant amount of work, few systems have been found to possess the requisite combination of properties or have been approved for clinical use. Luna Innovations proposes to develop a novel surgical adhesive system from blends of two naturally occurring and abundant polymers. The novel adhesive will combine the adhesive properties, hemostatic activity, tissue compatibility and biodegradability of a polycationic polysaccharide with the mechanical strength and tissue compatibility of a protein and will be modified further to include reactive "dangling" aldehyde groups. The adhesive properties of the blended adhesive system will be controllable by alteration of parameters such as composition, molecular weight, degree of crystallinity, crosslink density and density of free aldehyde groups. The proposed system will be prepared in a fully polymerized solid film version for the purpose of establishing feasibility. The film configuration will not be susceptible to inconsistent or improper mixing or flow often exhibited by multicomponent fluid systems that must be mixed immediately prior to use. The specific aims of the proposed program are designed to provide an understanding of structure/property relationships in this new class of materials while simultaneously establishing feasibility for its use in biomedical applications.

描述（由申请人提供）： 已经有许多方法来开发软组织粘合剂，这些粘合剂结合了组织相容性、易用性、良好的粘合和内聚强度、止血和促进伤口愈合。这些包括完全合成的方法和基于或利用天然化合物的方法。尽管工作量很大，但很少有系统被发现具有必要的特性组合或已被批准用于临床。 Luna Innovations 提议利用两种天然存在且丰富的聚合物的混合物开发一种新型手术粘合剂系统。 这种新型粘合剂将聚阳离子多糖的粘合性能、止血活性、组织相容性和生物降解性与蛋白质的机械强度和组织相容性相结合，并将进一步改性以包含反应性“悬挂”醛基。共混粘合剂体系的粘合性能可通过改变组成、分子量、结晶度、交联密度和游离醛基密度等参数来控制。为了建立可行性，所提出的系统将以完全聚合的固体薄膜形式制备。薄膜构造不会受到在使用前必须立即混合的多组分流体系统经常表现出的不一致或不适当的混合或流动的影响。该计划的具体目标旨在提供对此类新型材料的结构/性能关系的理解，同时建立其在生物医学应用中使用的可行性。