Interdisciplinary Pre-doctoral Training Program in Neuroengineering(RMI)

神经工程跨学科博士前培训项目（RMI）

• 批准号: 7485682
• 负责人: W. Mark Saltzman
• 金额: $ 43.57万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7485682
• 关键词: Accounting; Address; Admission activity; Advertising; Advisory Committees; Animals; Applied Research; Area; Artificial Organs; Arts; Behavior; Biochemical; Biochemical Pathway; Biochemistry; Biocompatible Materials; Bioenergetics; Biological; Biological Neural Networks; Biological Sciences; Biology; Biomechanics; Biomedical Engineering; Biomedical Research; Biophysics; Biosensor; Biotechnology; Blood - brain barrier anatomy; Blood Vessels; Brain; Cell Line; Cells; Cellular biology; Cerebral cortex; Chemical Engineering; Chemicals; Class; Cloning; Cochlear Implants; Cognitive; Communities; Competence; Complex; Computer Vision Systems; Consult; Country; Cryoelectron Microscopy; Cytidine Monophosphate; Data; Deep Brain Stimulation; Depth; Development; Devices; Diagnosis; Diffusion; Discipline; Doctor of Philosophy; Drug Delivery Systems; Dyes; Education; Educational Curriculum; Educational process of instructing; Educational workshop; Effectiveness; Electric Stimulation; Electrical Engineering; Electrodes; Elements; Engineering; Ensure; Environment; Equilibrium; Ethics; Evaluation; Event; Exercise Physiology; Exposure to; Facility Construction Funding Category; Faculty; Feedback; Fetal Tissues; Financial Support; Functional Magnetic Resonance Imaging; Future; Gene Structure; Genes; Genetic; Graduate Education; Grant; Group Meetings; Homeostasis; Hospitals; Hour; Human; Image; Imaging technology; Immersion Investigative Technique; In Vitro; Individual; Industry; Institution; Integrative Medicine; Interdisciplinary Study; Internships; Intervention; Investigation; Joints; Journals; Judgment; Kinetics; Laboratories; Laws; Lead; Learning; Left; Letters; Literature; Location; Magnetic Resonance; Magnetic Resonance Imaging; Mathematics; Measurement; Mechanics; Mediating; Medical; Medical Imaging; Membrane; Membrane Proteins; Mental disorders; Mentors; Methods; Microdialysis; Microfluidics; Mission; Modeling; Modems; Molecular; Molecular Machines; Monitor; Motor; Movement; Nature; Nervous System Physiology; Nervous system structure; Neuroanatomy; Neurobiology; Neurologic; Neurological Models; Neuronal Plasticity; Neurons; Neuropharmacology; Neurosciences; Neurotransmitters; New-Fill; Numbers; Oral; Oral Examination; Organ; Oxidative Phosphorylation; Paper; Participant; Pathway interactions; Perception; Performance; Peripheral Nervous System; Pharmacologic Substance; Pharmacology; Philosophy; Physics; Physiological; Physiology; Population; Positioning Attribute; Postdoctoral Fellow; Preparation; Procedures; Process; Production; Program Effectiveness; Program Evaluation; Property; Publications; Published Comment; Purpose; Qualifying; Rain; Range; Rate; Reaction; Reader; Readiness; Reading; Recording of previous events; Recruitment Activity; Recycling; Reporting; Research; Research Activity; Research Methodology; Research Personnel; Research Project Grants; Resources; Role; Rotation; Running; Schedule; Schools; Science; Scientist; Self-Evaluation Programs; Sensory; Series; Sorting - Cell Movement; Source; Speed; Spinal Cord; Stem cells; Structure; Students; System; Techniques; Technology; Testing; Text; Therapeutic; Thermodynamics; Thinking; Time; Tissue Engineering; Tissues; Training; Training Activity; Training Programs; Transmembrane Transport; Transport Process; United States National Institutes of Health; Universities; Vision; Visit; Visual system structure; Voting; Waiting Lists; Week; Work; Writing; awake; base; bioimaging; brain machine interface; career; chemotherapy; compound 351 A; controlled release; day; demographics; design; digital imaging; disorder prevention; experience; extracellular; falls; field study; fluid flow; human disease; image processing; in vivo; injured; innovation; insight; interest; journal article; lectures; lomustine/methotrexate/procarbazine protocol; medical schools; member; nerve stem cell; neurochemistry; neuroimaging; neuroimmunology; neurophysiology; neuroprosthesis; novel; optical imaging; peer; posters; pre-doctoral; professor; programs; prospective; prospectuses; protein structure; repaired; research and development; research study; response; role model; sensor; size; skills; statistics; strength training; symposium; teacher; theories; voltage

DESCRIPTION (provided by applicant): Quantitative approaches have a long history in the neurosciences, having contributed to the extraordinary progress made in understanding nervous system function at all levels of biological organization--from genes to behavior. Now, investigators from a variety of disciplines are beginning to incorporate engineering approaches in analyzing brain function, manipulating brain function, and building devices that duplicate or repair function lost in the injured brain. Into this rapidly evolving field of study, Yale proposes an Interdisciplinary Graduate Training Program in Neuroengineering. This proposal comes at an auspicious and important time in Yale's history: a new department of biomedical engineering was just formed, with a new research building under construction; a new center for magnetic resonance research was just opened with state-of-the-art research imaging capabilities; and the highly collaborative neuroscience community has grown to account for more than half of the university's biomedical research activity. Predoctoral students in the Neuroengineering Program would benefit from all of these institutional resources. By bringing 19 faculty members--representing 7 different departments and a large base of federally-supported individual and team grants--together in a unified training effort, the Neuroengineering program will: 1) prepare a group of scientists by full immersion in the disciplines of biomedical engineering and neuroscience; 2) create a new and vibrant interdisciplinary community at Yale; 3) develop new didactic courses and curriculum approaches for this field of study; and 4) implement a team approach for using quantitative biomedical engineering methods for solving complex problems in neuroscience. The students trained in this interdisciplinary program will be uniquely prepared to contribute to the academic and industrial workforce, and to speed progress towards diagnosis, treatment, and prevention of disease in the nervous system.

描述（由申请人提供）： 定量方法在神经科学领域有着悠久的历史，它为理解生物组织各个层面（从基因到行为）的神经系统功能取得了非凡的进展做出了贡献。现在，来自不同学科的研究人员开始采用工程方法来分析大脑功能、操纵大脑功能以及构建复制或修复受损大脑中丧失的功能的设备。针对这个快速发展的研究领域，耶鲁大学提出了神经工程学跨学科研究生培训计划。这一提议是在耶鲁大学历史上一个吉祥而重要的时刻提出的：新的生物医学工程系刚刚成立，新的研究大楼正在建设中；一个新的磁共振研究中心刚刚开业，拥有最先进的研究成像能力；高度协作的神经科学界已经发展到占大学生物医学研究活动的一半以上。神经工程项目的博士前学生将受益于所有这些机构资源。通过将 19 名教职人员（代表 7 个不同的院系以及大量联邦支持的个人和团队资助）聚集在一起进行统一培训，神经工程项目将：1) 培养一批完全沉浸在该学科中的科学家生物医学工程和神经科学； 2）在耶鲁创建一个新的、充满活力的跨学科社区； 3）为本研究领域开发新的教学课程和课程方法； 4）实施团队方法，使用定量生物医学工程方法来解决神经科学中的复杂问题。在这个跨学科项目中接受培训的学生将做好独特的准备，为学术和工业界做出贡献，并加快神经系统疾病诊断、治疗和预防的进展。

项目成果

Studies of the metabotropic glutamate receptor 5 radioligand [¹¹C]ABP688 with N-acetylcysteine challenge in rhesus monkeys.

在恒河猴中用 N-乙酰半胱氨酸激发代谢型谷氨酸受体 5 放射性配体 [11C]ABP688 的研究。

• 发表时间: 2013-08
• 作者: Sandiego, Christine M;Nabulsi, Nabeel;Lin, Shu;Labaree, David;Najafzadeh, Soheila;Huang, Yiyun;Cosgrove, Kelly;Carson, Richard E
• 通讯作者: Carson, Richard E

New platform for controlled and sustained delivery of the EGF receptor tyrosine kinase inhibitor AG1478 using poly(lactic-co-glycolic acid) microspheres.

使用聚（乳酸-乙醇酸）微球控制和持续递送 EGF 受体酪氨酸激酶抑制剂 AG1478 的新平台。

• 发表时间: 2010-05
• 影响因子: 3.9
• 作者: Robinson, Rebecca;Bertram, James P;Reiter, Jill L;Lavik, Erin B
• 通讯作者: Lavik, Erin B

Optimization of PET-MR registrations for nonhuman primates using mutual information measures: a Multi-Transform Method (MTM).

使用互信息测量优化非人类灵长类动物的 PET-MR 配准：多重转换方法 (MTM)。

• 发表时间: 2013-01-01
• 影响因子: 5.7
• 作者: Sandiego, Christine M;Weinzimmer, David;Carson, Richard E
• 通讯作者: Carson, Richard E

Awake nonhuman primate brain PET imaging with minimal head restraint: evaluation of GABAA-benzodiazepine binding with 11C-flumazenil in awake and anesthetized animals.

最小头枕的清醒非人类灵长类动物大脑 PET 成像：评估清醒和麻醉动物中 GABAA-苯二氮卓类药物与 11C-氟马西尼的结合。

• 发表时间: 2013-11
• 作者: Sandiego, Christine M;Jin, Xiao;Mulnix, Tim;Fowles, Krista;Labaree, David;Ropchan, Jim;Huang, Yiyun;Cosgrove, Kelly;Castner, Stacy A;Williams, Graham V;Wells, Lisa;Rabiner, Eugenii A;Carson, Richard E
• 通讯作者: Carson, Richard E

Sustained delivery of timolol maleate from poly(lactic-co-glycolic acid)/poly(lactic acid) microspheres for over 3 months.

从聚（乳酸-乙醇酸）/聚（乳酸）微球持续释放马来酸噻吗洛尔超过 3 个月。

• 发表时间: 2009-02
• 影响因子: 3.9
• 作者: Bertram, James P;Saluja, Sandeep S;McKain, Jodi;Lavik, Erin B
• 通讯作者: Lavik, Erin B