Project 1: Influence of Midlife on Functioning and Psychological Well-being in Early Old Age

项目1：中年对早年功能和心理健康的影响

• 批准号: 10471456
• 负责人: Sioban D Harlow
• 金额: $ 142.69万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10471456
• 关键词: Address; Affect; Age; Age of Onset; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; American; Black race; Bone Density; Characteristics; Chinese; Clinical; Cognition; Cognitive; Data; Data Analyses; Data Collection; Dementia; Elderly; Endocrine; Environment; Ethnic group; Functional disorder; Future; Genitourinary system; Gonadal Steroid Hormones; Health; Health Personnel; Hispanic; Impaired cognition; Independent Living; Japanese; Knowledge; Life; Life Experience; Lipids; Maintenance; Menopause; Menstruation; Modeling; Musculoskeletal; Outcome; Pattern; Personal Satisfaction; Physical Function; Population; Prevention; Prospective Studies; Quality of life; Resources; Risk; Role; Sex Functioning; Sexual Health; Site; Sleep; Sleep disturbances; Social Well-Being; Study of Women' s Health Across the Nation; Symptoms; Translating; Vasomotor; Well in self; Woman; Women' s Health; age related; cardiovascular health; cognitive change; cognitive function; cohort; computerized data processing; design; disability; ethnic difference; falls; family structure; health disparity; health related quality of life; healthy aging; human old age (65+); inflammatory marker; insight; men; middle age; mild cognitive impairment; mortality; multiple chronic conditions; physically handicapped; preservation; prospective; psychosocial; psychosocial wellbeing; racial and ethnic; racial and ethnic disparities; racial diversity; reproductive senescence; sleep health; socioeconomics; stressor; therapy design

Women live longer with disability than men and constitute a disproportionate share of the population receiving assistance with daily activities. Cognitive decline (including age-related mild cognitive impairment, Alzheimer’s disease and Alzheimer’s disease related dementia), disrupted sleep, genitourinary symptoms and activity limitations increasingly affect women’s health and well-being as they age. Studies on aging highlight the midlife (age 40-65 years) as a critical life stage for prevention of cognitive impairment, dementia, Alzheimer’s disease, physical disability and multi-morbidity in old age. In women, the midlife encompasses the menopause transition (MT), characterized by significant changes in women’s endocrine environment, alterations in health indicators (e.g., bone mineral density, lipids, inflammatory markers), changes in family structure and social roles, and new stressors, all of which can affect cognition, functioning and well-being in later life. The 22-year multi-site Study of Women’s Health Across the Nation (SWAN) is the most comprehensive prospective study describing characteristics of the MT and elucidating relationships between the MT and change in numerous domains of health and cognitive, physical and psychosocial function in a diverse racial/ethnic cohort (Black, Chinese, Hispanic, Japanese and White women). This U19 application is designed to assess the extent to which midlife health and the MT affect risk for cognitive decline/mild cognitive impairment and physical disability, or promote psychosocial well-being and successful aging. Building on SWAN’s comprehensive midlife assessments, Project 1 will evaluate the impact of MT characteristics and MT/midlife-aging-related changes in health indicators on multiple domains of functioning in early old age (ages 66-75 years). Specific Aims of this Project are to: 1) Evaluate the impact of MT characteristics and trajectories of midlife health indicators on preservation of cognitive function (avoiding cognitive decline and onset of mild cognitive impairment), sleep health, genitourinary and sexual function, and ability for independent living in early old age; 2) Evaluate the impact of MT characteristics and trajectories of health indicators on the preservation of psychological well-being and HRQL in early old age; 3) Determine the extent to which racial/ethnic health disparities in functioning and well-being in early old age are attributable to racial/ethnic differences in MT characteristics and midlife health trajectories; and 4) Translate for women and their health care providers findings regarding the relation of the MT/midlife health to cognition, functioning and well-being in early-old age. Integrating across Projects, we will examine associations of cognitive, physical and psychosocial functioning with cardiovascular health and mortality (Project 2) and with musculoskeletal health and falls (Project 3). Resources of the three Cores are essential to the data collection, data processing and analyses proposed. Knowledge gained from Project 1 will facilitate identification of midlife prevention targets to delay or avoid mild cognitive impairment, preserve functioning, maintain independence, and optimize quality of life in early old age.

妇女的寿命比男性居住的时间更长，并且在日常活动中获得援助的人口（包括年龄相关的轻度认知障碍，阿尔茨海默氏病和阿尔茨海默氏病有关的衰弱）的抑制症状和活动限制越来越多地影响妇女的健康。年龄40-65岁）Gnive障碍，痴呆症，阿尔茨海默氏病，身体上的遗漏和多数级，在女性中，更年期过渡（MT），其特征是女性的内分泌环境健康指标（例如，骨骼矿物质密度，，骨骼矿物质密度，，脂质，炎症标志物），家庭结构和社会角色的变化以及新的努力，所有这些都会影响生活中22年的多站点研究中的认知，运作和福祉。最全面的前瞻性研究描述了MT和认知C，日本和白人妇女的MT和变化之间的MT关系的特征。认知能力下降/轻度的认知障碍和对天鹅全面评估的身体残疾，项目1的MT特征的影响以及与中年与中期有关的ES在健康指标上对年龄较早的多阶段功能领域（66-75岁） MT中期健康指标的MT特征和轨迹对保留认知功能的保存和轻度认知障碍的发作）A降低了MT特征的影响和健康指标对保存心理健康和HRQL的影响归因于RAC的年龄段的种族/族裔健康差异。 /对年龄的认知，运作和福祉，我们将检查认知，身体和心理社会的联系与心血管健康和死亡率以及肌肉骨骼健康和跌倒的关联（项目3） ，保留功能，保持独立性并优化老年时期的生活质量。