STRAW+10: Addressing the Unfinished Agenda of Staging Reproductive Aging - RESUBM

STRAW 10：解决生殖衰老阶段未完成的议程 - RESUBM

• 批准号: 8202368
• 负责人: Sioban D Harlow
• 金额: $ 5.35万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8202368
• 关键词: AIDS/HIV problem; Address; Adopted; Aging; Algorithms; American; Antral; Biological Markers; Body mass index; Bone Resorption; Categories; Child; Child health care; Chronic Disease; Classification; Climacteric; Clinical; Clinical Trials; Consensus; Contraceptive Agents; Data; Decision Making; District of Columbia; Educational workshop; Endocrine; Endocrine System Diseases; Ensure; Fertility; Follicle Stimulating Hormone; Funding; Gender; Gold; Gynecologic Surgical Procedures; Health; Healthcare; Hormones; Human Development; Hypothalamic structure; Institutes; International; Journals; Knowledge; Life; Lipids; Medicine; Menopausal Status; Menopause; Menstruation; Mental Depression; Modeling; Modification; National Institute on Aging; Nomenclature; Outcome; Ovarian; Peer Review; Physiological; Postmenopause; PubMed; Puberty; Publishing; Quality of life; Recommendation; Recording of previous events; Reproductive Medicine; Research; Research Personnel; Research Priority; Risk; Sleep disturbances; Smoke; Societies; Specific qualifier value; Staging; Staging System; Sterility; Symptoms; Syndrome; Time; Translating; United States; Update; Uterine hemorrhage; Woman; Women' s Group; Women' s Health; base; bone; chemotherapy; critical period; experience; healthy aging; hormone therapy; indexing; inhibin B; meetings; middle age; mullerian-inhibiting hormone; multidisciplinary; population based; reproductive; research study; senescence; success; symposium; tool; web site; working group

DESCRIPTION (provided by applicant): We propose a multi-disciplinary symposium "STRAW+10: Addressing the Unfinished Agenda of Staging Reproductive Aging" to update the 2001 Stages of Reproductive Aging Workshop (STRAW) recommendations. The menopausal transition is a period of critical change, including loss of fertility, increased bone resorption, change in lipid profiles and temporal increases in symptoms, sleep disturbances and depression. STRAW proposed nomenclature, a staging system, and menstrual and endocrine criteria to define stages of ovarian aging. It has become the gold standard for characterizing reproductive aging, as the Tanner Stages characterize puberty. In the past decade, understanding of the critical junctures in hypothalamic and ovarian function before and after the final menstrual period and their implications for women's health has advanced considerably. We will convene 30 investigators from key research groups in the United States and worldwide. The specific aims are to refine criteria for the early menopausal transition given new population-based data relating to follicle-stimulating hormone, antral follicle count, anti-mullerian hormone and inhibin-B; to assess how to include women with higher body-mass-index and who smoke in staging algorithms; to provide recommendations regarding staging of women following gynecological surgery, chemotherapy, and hormone therapy and in women with polycystic ovarian syndrome and chronic diseases such as HIV/AIDS; and to assess potential criteria for staging the post-menopause. The Day 1 public scientific sessions will present recent advances and discuss implications of new data for staging. On Day 2, small working groups will propose modifications to the STRAW criteria. Following discussion, final recommendations will be adopted and research priorities defined. The expected outcome will be a set of recommendations for modifying the STRAW criteria that characterize the end stages of reproductive life including their extension to be more broadly applicable to the range of women's experience. Short- and long-term research priorities will be specified including studies needed to replicate and validate proposed criteria as well as to address gaps in knowledge. The meeting, co-sponsored by The North American Menopause Society (NAMS), The American Society for Reproductive Medicine, The International Menopause Society and The Endocrine Society, will be held September 20-21, 2011 prior to the NAMS Annual Meeting in Washington D.C. STRAW+10 recommendations will be presented at the NAMS meeting. A peer-reviewed executive summary will be published simultaneously in the co-sponsors' journals, Climacteric, Menopause, Fertility and Sterility; with a non-technical version published on their websites. The STRAW+10 staging system will facilitate consistent classification of menopausal status, ensuring comparability of research studies and clinical trials. Once specified, a staging system can be developed into a clinical tool to guide assessment of fertility and contraceptive choices, and healthcare decision-making. Funds will be allocated to support participation of 4 trainees/new investigators. PUBLIC HEALTH RELEVANCE: The purpose of this multi-disciplinary 2-day symposium is to organize and synthesize knowledge accumulated during the past decade in order to update the 2001 Stages of Reproductive Aging Workshop (STRAW) model for staging the end of reproductive life in women. We also propose to extend the STRAW recommendations to be more broadly applicable to the range of women's diverse experience of reproductive aging.

描述（由申请人提供）：我们提出了一个多学科研讨会“稻草+10：解决分期生殖老化的未完成的议程”，以更新2001年生殖老化工作室（Straw）建议的阶段。 更年期过渡是一个关键变化的时期，包括失去生育能力，骨吸收增加，脂质谱的变化以及症状的时间增加，睡眠障碍和抑郁症。稻草提出的命名法，一个分期系统以及月经和内分泌标准，以定义卵巢衰老的阶段。随着坦纳（Tanner）的特征是青春期的特征，它已成为表征生殖衰老的金标准。在过去的十年中，在最后一个月经期之前和之后，了解下丘脑和卵巢功能的关键关键时刻及其对妇女健康的影响已经大大发展。我们将召集来自美国和全球关键研究小组的30名调查人员。 鉴于与促卵泡刺激激素，鼻卵泡计数，抗毛糖激素和抑制素B有关的新的基于人群的数据，具体目的是完善早期绝经过渡的标准；评估如何包括较高的身体质量索引的女性以及在分期算法中吸烟的女性；提供有关妇科手术，化学疗法和激素治疗以及多囊卵巢综合征和慢性疾病（例如HIV/AIDS）的女性的建议；并评估潜在的标准，用于上演春季。第1天的公共科学会议将介绍最新进展，并讨论新数据进行分期的含义。在第2天，小型工作组将提出对稻草标准的修改。在讨论之后，将采用最终建议并定义研究优先级。预期的结果将是一系列建议，以修改稻草标准，这些标准是生殖生活的终点，包括其扩展，更广泛地适用于妇女的经验范围。将指定短期和长期研究优先级，包括复制和验证提出的标准所需的研究以及解决知识差距。 该会议由北美更年期学会（NAMS），美国生殖医学学会，国际更年期学会和内分泌学会共同赞助，将于2011年9月20日至21日在华盛顿特区的NAMS年度会议之前举行。稻草+10个建议将在NAMS会议上提出。经过同行评审的执行摘要将同时发表在共同赞助商的期刊《高原，更年期》，生育和不育的期刊上；在其网站上发布了非技术版本。 Straw+10分期系统将有助于对更年期状态的一致分类，从而确保研究和临床试验的可比性。一旦指定，就可以将分期系统发展成为一种临床工具，以指导评估生育能力和避孕选择以及医疗保健决策。资金将分配给4名受训者/新调查员的参与。 公共卫生相关性：这次多学科为期2天研讨会的目的是组织和综合过去十年中积累的知识，以更新2001年生殖老化研讨会（Straw）模型的2001阶段，以实现女性生殖生活的终结。我们还建议扩展稻草建议，以更广泛地适用于妇女多样化的生殖衰老经验。