Sleep Dysfunction and Neurocognitive Outcomes in Adolescent ADHD

青少年多动症的睡眠障碍和神经认知结果

基本信息

批准号：
10456382
负责人：
Jessica Ruth Lunsford-Avery
金额：
$ 5.27万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-08-01 至 2022-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10456382
关键词：
Address Administrative Supplement Adolescence Adolescent Adult Affect Applications Grants Attention deficit hyperactivity disorder Biological COVID-19 COVID-19 pandemic Childhood Clinical Data Data Analyses Development Electroencephalography Emotional Enrollment Ensure Funding Future Goals Grant Home Hormonal Hyperactivity Impairment Impulsivity Intervention Laboratories Manuscripts Measures Memory Mentored Patient-Oriented Research Career Development Award Mentors Motivation Neurobiology Neurocognition Neurocognitive Neurocognitive Deficit Outcome Parents Phenotype Polysomnography Population Preparation Prevention program Procedures Protocols documentation Research Research Activity Research Training Resources Role Sampling Severities Sleep Sleep Deprivation Sleep Disorders Sleep disturbances Social outcome Subgroup Symptoms Testing Time Training Translational Research Youth base career development computerized data processing critical developmental period design executive function experience inattention innovation interest pandemic disease parent project phenotypic biomarker preventive intervention programs psychosocial recruit research and development sleep behavior sleep difficulty sleep onset sleep physiology sleep spindle social sustained attention symposium treatment program vigilance

项目摘要

Attention-Deficit/Hyperactivity Disorder (ADHD) in adolescence is frequently predictive of detrimental academic and social outcomes. In part, poor functioning may be due to neurocognitive deficits observed in ADHD; however, the extent of these deficits is variable and the mechanisms contributing to greater impairment in some youth and not others are poorly understood. Sleep disturbance represents one potential contributor to the neurocognitive deficits observed in a subset of youth with ADHD. Specifically, disturbed sleep is prevalent in ADHD and there is considerable overlap between core ADHD features and the neurocognitive correlates of sleep impairment. However, associations between sleep physiology and variable clinical and neurocognitive outcomes in adolescents with ADHD have yet to be investigated. The parent project uses polysomnography to assess sleep disturbance and neurocognitive outcomes in adolescents with ADHD and healthy controls (HC). The primary hypothesis predicts that adolescents with ADHD will display reduced duration, increased latency, increased nocturnal awakenings, reduced delta power, and disrupted sleep spindles compared to HC. Variability within groups is predicted, and we will explore whether there are distinct subgroups with and without sleep problems within the ADHD group. In addition, sleep disturbance is predicted to be associated with poorer neurocognitive and clinical presentations in adolescents with ADHD. If these hypotheses are supported, sleep disturbance may represent a biomarker for phenotypic subtypes of ADHD. Examining this construct may also inform development of prevention and intervention strategies with the potential to impact sleep disturbance and core symptoms of ADHD in adolescents. The career development goal of the parent K23 Mentored Patient- Oriented Research Career Development Award is to broaden Dr. Jessica Lunsford-Avery's expertise in sleep disturbance and neurocognition in adolescents with ADHD. Training objectives include gaining expertise in advanced laboratory-based administration, scoring, and analysis of polysomnographic data; assessment of neurocognitive and clinical correlates of sleep impairment in ADHD; and enhanced understanding of developmental trajectories of sleep in typically developing adolescents and those with ADHD. These objectives are underway through mentoring, research, and coursework, which will result in an independently funded program of research to elucidate the biological mechanisms underlying sleep problems and neurocognitive impairment in ADHD and develop innovative sleep-based interventions targeting core symptoms in this population. The proposed supplement addresses both research and career development objectives and will allow for 1) provision of essential training in scoring of polysomnographic data for spectral analysis and translational research, 2) data processing and analysis, and 3) preparation of manuscripts and R01 grant applications. Moreover, the proposed supplement will offset the loss of time and effort associated with COVID- 19 and will provide the necessary resources to support Dr. Lunsford-Avery's transition to independence.

青春期注意力缺陷/多动症（ADHD）经常可以预测有害学术和社会成果。在某种程度上，功能较差可能是由于ADHD中观察到的神经认知缺陷。但是，这些缺陷的程度是可变的，机制有助于更大的损害一些年轻人而不是其他年轻人的理解不足。睡眠障碍代表了一个潜在的贡献者在ADHD青年的一部分中观察到的神经认知缺陷。具体而言，睡眠不足很普遍在多动症中，核心多动症特征与神经认知相关性之间存在相当大的重叠睡眠障碍。但是，睡眠生理学与可变临床和神经认知之间的关联患有多动症的青少年的结果尚未研究。家长项目使用多肌分摄影评估ADHD和健康对照青少年（HC）的睡眠障碍和神经认知结果。主要假设预测，患有多动症的青少年将显示持续时间降低，潜伏期增加，与HC相比，夜间觉醒的增加，增量功率降低和睡眠纺锤体破坏。预测组内的可变性，我们将探讨是否有不同的子组多动症组中的睡眠问题。另外，预计睡眠障碍与较差有关 ADHD青少年的神经认知和临床表现。如果支持这些假设，请睡觉扰动可能代表ADHD表型亚型的生物标志物。检查这个结构也可能告知预防和干预策略的发展，有可能影响睡眠障碍和青少年多动症的核心症状。父母K23的职业发展目标指导了患者 - 面向研究的研究职业发展奖是为了扩大杰西卡·伦斯福德博士的睡眠专业知识 ADHD青少年的障碍和神经认知。培训目标包括获得专业知识基于实验室的高级给药，评分和分析多个学术数据；评估 ADHD中睡眠障碍的神经认知和临床相关性；并加强对典型发展的青少年和患有多动症的人的睡眠发展轨迹。这些目标正在进行指导，研究和课程，这将导致独立资助研究计划，以阐明睡眠问题和神经认知的生物学机制 ADHD的损害并开发了针对核心症状的创新基于睡眠的干预措施人口。拟议的补充剂涵盖了研究和职业发展目标，并将允许1）在评分多个学术数据中提供基本培训，以进行光谱分析和翻译研究，2）数据处理和分析，以及3）手稿的准备和R01赠款申请。此外，拟议的补充剂将抵消与covid-相关的时间和精力的损失 19并将提供必要的资源来支持伦斯福德博士 - 贫穷向独立的过渡。

项目成果

期刊论文数量（18）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Sluggish Cognitive Tempo in Adults Referred for an ADHD Evaluation: A Psychometric Analysis of Self- and Collateral Report.

DOI：
10.1177/1087054718787894
发表时间：
2021-03
期刊：
Journal of attention disorders
影响因子：
3
作者：
Lunsford-Avery JR;Kollins SH;Mitchell JT
通讯作者：
Mitchell JT

Overnight Delta Dynamics Associated with Daytime Psychomotor Performance in Adults with Insomnia and Healthy Controls.

DOI：
10.2147/nss.s330939
发表时间：
2022
期刊：
Nature and science of sleep
影响因子：
3.4
作者：
Lunsford-Avery JR;Edinger JD;Krystal AD
通讯作者：
Krystal AD

Regularity and Timing of Sleep Patterns and Behavioral Health Among Adolescents.

DOI：
10.1097/dbp.0000000000001013
发表时间：
2022-05-01
期刊：
JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
影响因子：
2.4
作者：
Lunsford-Avery, Jessica R.;(Will) Wang, Ke;Kollins, Scott H.;Chung, Richard J.;Keller, Casey;Engelhard, Matthew M.
通讯作者：
Engelhard, Matthew M.

Sluggish cognitive tempo (SCT) in an adult outpatient sample seeking an attention-deficit/hyperactivity disorder assessment: Age of onset and assessment method impact on SCT rates.