Threat-Related Negative Valence Systems, Child Victimization, and Anxiety_Supplement

与威胁相关的负价系统、儿童受害和焦虑_补充

• 批准号: 10597417
• 负责人: CARLA KMETT DANIELSON
• 金额: $ 22.11万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10597417
• 关键词: Accounting; Acute; Address; Administrative Supplement; Adolescence; Affect; Age; Amygdaloid structure; Anterior; Anxiety; Behavioral; Biological; COVID-19 pandemic; Childhood; Classification; Clinical assessments; Collection; Communities; Data Collection; Development; Diagnosis; Ensure; Event-Related Potentials; Exposure to; Funding; Goals; Guidelines; Hydrocortisone; Insula of Reil; Interpersonal Violence; Intervention; Lead; Link; Longevity; Longitudinal Studies; Longitudinal cohort; Measures; Mediating; Mental Health; Mental disorders; Negative Valence; Outcome; Panic; Participant; Pattern; Persons; Phenotype; Physiological; Physiology; Plant Roots; Prevention; Psychopathology; Research; Research Domain Criteria; Risk; Risk Factors; Sampling; Societies; Startle Reaction; Symptoms; System; Telephone; Testing; Time; TimeLine; Translating; Visit; Writing; Youth; anxiety states; anxiety symptoms; anxious; associated symptom; base; boys; child and adolescent victimization; cingulate cortex; cohort; cost; data cleaning; design; emotional distress; experience; follow-up; functional MRI scan; girls; improved; magnetic resonance imaging/electroencephalography; neuroimaging; pandemic disease; parent project; participant retention; personalized medicine; physical conditioning; predicting response; psychologic; recruit; relating to nervous system; resilience; response; self-reported anxiety; sex; violence exposure; Accounting; Acute; Address; Administrative Supplement; Adolescence; Affect; Age; Amygdaloid structure; Anterior; Anxiety; Behavioral; Biological; COVID-19 pandemic; Childhood; Classification; Clinical assessments; Collection; Communities; Data Collection; Development; Diagnosis; Ensure; Event-Related Potentials; Exposure to; Funding; Goals; Guidelines; Hydrocortisone; Insula of Reil; Interpersonal Violence; Intervention; Lead; Link; Longevity; Longitudinal Studies; Longitudinal cohort; Measures; Mediating; Mental Health; Mental disorders; Negative Valence; Outcome; Panic; Participant; Pattern; Persons; Phenotype; Physiological; Physiology; Plant Roots; Prevention; Psychopathology; Research; Research Domain Criteria; Risk; Risk Factors; Sampling; Societies; Startle Reaction; Symptoms; System; Telephone; Testing; Time; TimeLine; Translating; Visit; Writing; Youth; anxiety states; anxiety symptoms; anxious; associated symptom; base; boys; child and adolescent victimization; cingulate cortex; cohort; cost; data cleaning; design; emotional distress; experience; follow-up; functional MRI scan; girls; improved; magnetic resonance imaging/electroencephalography; neuroimaging; pandemic disease; parent project; participant retention; personalized medicine; physical conditioning; predicting response; psychologic; recruit; relating to nervous system; resilience; response; self-reported anxiety; sex; violence exposure

Interpersonal violence (IPV) exposure affects 1 in 2 youth and levies tremendous physical and mental health burdens on victims and society. Childhood IPV exposure is a well-established risk factor for anxiety and other mental health problems across the lifespan. A paucity of longitudinal studies assessing multiple threat-related mechanisms, across multiple units of analysis, and at key times in development has been a critical barrier to informing the design of personalized treatments to target root causes of post-IPV psychopathology. The overarching goal of this project (the “CHARM study”) is to examine developmental trajectories of threat-related NVS measures into adolescence, as a function of exposure to IPV, in an effort to better link IPV and anxiety through changes in these measures. The specific aims of this project are: 1) to identify threat-related NVS constructs that connect lifetime IPV to anxious symptoms in youth cross-sectionally; 2) to investigate longitudinally the degree to which IPV sensitizes trajectories of NVS measures across three age cohorts (grades 3, 6, 9 at baseline); and 3) to investigate the degree to which trajectories of NVS measures predict anxiety symptoms over time after accounting for initial anxiety symptoms and IPV status. The study had successfully recruited its full sample (N=364) and longitudinal retention was progressing as planned until March, 2020, when the COVID-19 pandemic (and subsequent mandatory guidelines impacting in-person data collection) reduced retention across the representative sample. Pandemic disruptions have required increased intensive efforts in participant retention, particularly for the final assessment (Lab Visit 3) that includes the follow-up fMRI scan, which has translated into a delayed timeline and increased costs. The proposed Administrative Supplement is essential to help cover these unexpected costs to complete the outstanding in-person data collection, as well as final data cleaning, analysis, and write up of results, ensuring that the longitudinal aims are successfully met and that maximum impact is yielded from the study.

人际关系暴力（IPV）暴露会影响2名青年中的1个，征收巨大的身心健康 负担恐怖和社会。儿童IPV暴露是动画和其他其他的危险因素 整个生命周期的心理健康问题。纵向研究很少评估多重威胁相关的研究 机制，跨多个分析单元，以及在开发的关键时期一直是一个关键的障碍 告知个性化治疗方法的设计，以针对IPV后心理病理学的根本原因。这 该项目的总体目标（“魅力研究”）是检查与威胁有关的发展轨迹 NVS衡量青少年，作为暴露于IPV的函数，以更好地将IPV和焦虑联系起来 通过这些措施的改变。该项目的具体目的是：1）确定与威胁相关的NVS 将生命周期IPV与青年横截面中的焦虑症状联系起来的构造； 2）调查 纵向IPV感官在三个年龄群体中的NVS测量轨迹的程度（等级） 基线时3、6、9）; 3）研究NVS措施的轨迹预测动画的程度 考虑最初的焦虑症状和IPV状态后，随着时间的推移症状。这项研究成功了 招募了其完整的样本（n = 364），并且按计划进行纵向保留，直到2020年3月， COVID-19大流行（以及随后影响亲自数据收集的强制性指南）减少了 在代表性样本中保留。大流行的破坏需要加大强化努力 特别保留，特别是对于最终评估（实验室访问3），其中包括fMRI扫描， 这转化为时间表延迟和成本增加。拟议的行政补充是 有助于支付这些意外费用以完成出色的面对面数据收集以及 最终数据清洁，分析和撰写结果，以确保成功实现纵向目标并 该研究产生了最大影响。