Nurses Health Study 3: A multiple exposure environmental epidemiology cohort of young adults

护士健康研究 3：年轻人多次暴露环境流行病学队列

• 批准号: 10440077
• 负责人: Jorge Eduardo Chavarro
• 金额: $ 5.9万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-10 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10440077
• 关键词: 2019-nCoV; Address; Administrative Supplement; Adolescence; Area; Big Data Methods; Biological; Blood; COVID-19 testing; Canada; Characteristics; Chronic Disease; Collection; Data; Data Collection; Diet; Enrollment; Environment; Environmental Epidemiology; Environmental Exposure; Environmental Risk Factor; Environmental and Occupational Exposure; Feces; Female; Individual; Infection; Infrastructure; Infrastructure Activities; Investigation; Knowledge; Life Cycle Stages; Measurement; Menopause; Modernization; Monoclonal Antibody R24; Nurses' Health Study; Online Systems; Parents; Participant; Physical activity; Pregnancy; Pregnancy Histories; Prospective cohort study; Psychosocial Factor; Research; Research Personnel; Resources; Risk Factors; Role; SARS-CoV-2 antibody; Sampling; Specimen; Symptoms; Technology; Technology Assessment; Time; Uncertainty; United States; Urine; Vial device; cohort; cost effective; disorder risk; experience; geographic risk; innovation; mobile computing; novel; operation; parent project; prospective; residence; sample collection; young adult

PROJECT SUMMARY OF PARENT PROJECT (R24ES028521) This is an R24 application to support the infrastructure of our environmental epidemiology cohort, Nurses’ Health Study 3 (NHS3), an open, prospective, web-based cohort (www.nhs3.org). Participants are residence of the United States and Canada born after 1965. Most of the female participants (89%) have enrolled before menopause and 41% of female participants and 62% ofmale participants have no prior pregnancy history. In this innovative web-based study, we have been collecting detailed information on personal characteristics and potential disease risk factors every 6 months, including diet, physical activity, psychosocial factors, and a wide variety of occupational and environmental exposures. Data collection has focused on current exposures, as well as those experienced during adolescence, prior to first pregnancy, and during pregnancy.Discoveries made in NHS3 will build on the knowledge and experience gained from earlier cohorts on the impacts of the environment on chronic disease risk but takes advantage of modern technology to collect novel prospective data during important windows of exposure across the life course. The NHS3 investigators have substantial experience in environmental epidemiology,exposure assessment, and Big Data analytics, as well as in managing and maintaining large prospective cohort studies. This cohort provides a unique opportunity to address key outstanding questions in environmental epidemiology, by collecting highly detailed information on multiple environmental exposures at key points in the life course. The R24 supports infrastructure activities in the expanded NHS3 cohort thatmaximize the existing resources and broaden the current scope of research, to allow the investigation of multiple environmental exposures. We will focus our efforts in three main areas: 1) the expansion of study operations and maximization of existing resources, 2) the collection of environmental exposure samples, and 3) expansion of web-based mobile technologies and assessment of spatial uncertainty and measurement error. We have partnered with U01HL145386 to collect biologic samples (blood, urine, stool) concurrently with the environment exposure samples. This administrative supplement will allow us to prepare cost-effective lab-ready vials of both biologic and environmental specimens at the time of collection.

父项目 (R24ES028521) 的项目摘要 这是一个 R24 应用程序，用于支持我们环境流行病学队列的基础设施， 护士健康研究 3 (NHS3)，一个开放的、前瞻性的、基于网络的队列 (www.nhs3.org)。 参与者是居住在美国和加拿大的1965年以后出生的人。大多数是女性 参与者 (89%) 在绝经前就已入组，其中 41% 的女性参与者和 62% 的男性参与者 在这项基于网络的创新研究中，参与者没有怀孕史。 每 6 次收集个人特征和潜在疾病危险因素的详细信息 月，包括饮食、体力活动、心理社会因素和各种职业 数据收集侧重于当前暴露以及那些暴露。 在青春期、第一次怀孕之前和怀孕期间经历过。 NHS3 将建立在从早期队列中获得的有关以下因素影响的知识和经验的基础上： 环境对慢性病风险的影响，但利用现代技术收集新的 NHS3 生命历程中重要暴露窗口期的前瞻性数据。 调查人员在环境流行病学、暴露评估和 大数据分析，以及管理和大型前瞻性队列研究。 队列提供了解决环境中关键突出问题的独特机会 流行病学，通过收集有关多种环境暴露的非常详细的信息 生命历程中的关键点。 R24 支持扩大的 NHS3 队列中的基础设施活动，最大限度地利用现有资源 资源并扩大当前的研究范围，以允许进行多种调查 我们将集中精力在三个主要领域：1）扩大研究范围。 现有资源的运营和最大化，2）环境暴露的收集 样本，以及 3) 基于网络的移动技术的扩展和空间不确定性的评估 我们与U01HL145386合作采集生物样本（血液、 尿液、粪便）与环境暴露样本同时进行。 使我们能够在实验室制备具有成本效益的生物和环境样本小瓶 收集时间。

项目成果

Occupational exposure to high-level disinfectants and risk of miscarriage among nurses.

• DOI: 10.1136/oemed-2020-107297
• 发表时间: 2021-10
• 期刊: Occupational and environmental medicine
• 影响因子: 4.9
• 作者: Ding M;Lawson C;Johnson C;Rich-Edwards J;Gaskins AJ;Boiano J;Henn S;Rocheleau C;Chavarro JE
• 通讯作者: Chavarro JE

Occupational use of high-level disinfectants and asthma incidence in early- to mid-career female nurses: a prospective cohort study.

• DOI: 10.1136/oemed-2020-106793
• 发表时间: 2021-04
• 期刊: Occupational and environmental medicine
• 影响因子: 4.9
• 作者: Dumas O;Gaskins AJ;Boggs KM;Henn SA;Le Moual N;Varraso R;Chavarro JE;Camargo CA Jr
• 通讯作者: Camargo CA Jr

Demographic and behavioural correlates of energy drink consumption.

• DOI: 10.1017/s1368980022001902
• 发表时间: 2023-07
• 期刊: PUBLIC HEALTH NUTRITION
• 影响因子: 3.2
• 作者: Markon, Andre O.;Ding, Ming;Chavarro, Jorge E.;Wolpert, Beverly J.
• 通讯作者: Wolpert, Beverly J.