Childhood and Adult Psychosocial Stress and the Association with Disparities in Adult Cardiometabolic Health

儿童和成人心理社会压力以及与成人心脏代谢健康差异的关联

基本信息

批准号：
10478317
负责人：
Jorge Eduardo Chavarro
金额：
$ 9.81万
依托单位：
HARVARD SCHOOL OF PUBLIC HEALTH
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-02-08 至 2026-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10478317
关键词：
Acute Adult Adverse effects Affect Age Alcohols Anthropometry Asian Asian population Biological Black Populations COVID-19 Cardiometabolic Disease Cardiovascular Diseases Cellular Phone Characteristics Child Childhood Chronic Chronic Disease Collection Communities Complex Data Data Set Diet Discrimination Dose Employment Environment Ethnic Origin Event Exposure to Family Female Financial Hardship Generations Geographic Locations Geography Goals Health Health behavior Heart Diseases Hispanic Hispanic Populations Hypertension Income Individual Inequality Infrastructure Life Life course epidemiology Light Link Lung diseases Measures Mentorship Minority Neighborhoods Not Hispanic or Latino Nurses Obesity Outcome Pattern Persons Phenotype Physical activity Plant Roots Prevalence Process Psychosocial Stress Public Health Race Research Resolution Resources Risk Risk Factors Role Safety Sexual abuse Smoking Social Processes Socioeconomic Status Stress Stressful Event Time Translating United States Visit Vulnerable Populations Woman Work adverse childhood events age group base cardiometabolic risk cardiometabolism childhood adversity cohort contextual factors data visualization digital directed attention disorder risk epidemiology study experience health disparity high risk high risk population indexing innovation insight novel pandemic disease parent grant physical abuse psychologic psychosocial stressors racial and ethnic racial and ethnic disparities racial disparity resilience response social social capital spatiotemporal stressor substance use traumatic event

项目摘要

PROJECT SUMMARY Life-course epidemiology directs attention to the connection between childhood experiences and adult health, and increasing research indicates that many of the most burdensome chronic diseases globally are rooted in childhood. Research shows adults who experience four or more types of adverse childhood experiences (ACEs) (i.e., potentially traumatic events or aspects of a child’s environment that undermine their sense of safety and stability) have roughly twice the odds of obesity and cardiovascular disease — and even greater odds for high-risk health behaviors—relative to adults who did not experience adversity in childhood. This relation is burgeoning and remains under- explored among different age groups, socio-economic status (SES), and race/ethnicities. In addition to ACEs, stressors experienced as an adult have been linked to increased risk of poor health outcomes. Also, SES and non-white race have been associated with higher ACE prevalence as well as increased presence of risk factors for cardiometabolic disease. However, less is known about how cumulative stress (i.e., the combination of adult, acute, and chronic stressors) influences cardiometabolic disease risk over a period of time. The “Integrating Lifecourse Approaches, Biological, and Digital Phenotyping in Support of Heart and Lung Disease Epidemiologic Research” parent grant focuses on strengthening infrastructure necessary to collect data on traditional and emerging risk factors for heart and lung diseases. The goal of the proposed supplemental research is to translate the activities of the parent grant and identify early life risk factors – and their interplay with other psychosocial stressors experienced in adulthood -- in multiple generations for cardiometabolic disease, ultimately supporting work towards reducing these risk factors among high-risk populations. As such, the research aims are as follows: (Aim1) To Investigate racial/ethnic and geographic/demographic predictors of childhood psychosocial stress – and their interactions with socio-economic status (SES) – among adult women; (Aim2) To identify how ACEs combine with adult experiences of stress to predict cardiometabolic disease and examine the extent to which cumulative stress contributes to racial disparities in the risk factors of cardiometabolic disease; and (Aim3) To understand contextual factors that might reduce or exacerbate the association between psychosocial stressors and cardiometabolic outcomes, through smartphone digital phenotyping and the collection and analysis of geospatial datasets. The proposed supplemental research has important public health implications.

项目概要生命历程流行病学将注意力集中在童年经历和成人健康，越来越多的研究表明，许多最令人负担的慢性疾病研究表明，在全球范围内，成年人都经历过四种或更多类型的疾病。不良童年经历（ACE）（即潜在的创伤事件或儿童的某些方面）破坏安全感和稳定感的环境）的肥胖几率大约是其两倍和心血管疾病——甚至更高风险健康行为的可能性——相对于童年时期没有经历过逆境的成年人之间的这种关系正在迅速发展，并且仍然处于低水平。此外，还对不同年龄组、社会经济地位（SES）和种族/民族进行了探讨。对于 ACE，成年人经历的压力源与健康状况不佳的风险增加有关此外，SES 和非白人种族也与较高的 ACE 患病率相关。然而，人们对心脏代谢疾病危险因素的增加知之甚少。累积压力（即成人、急性和慢性压力源的组合）影响一段时间内的心脏代谢疾病风险。 “支持心肺疾病流行病学研究的生物和数字表型分析” 家长赠款的重点是加强收集传统和传统数据所需的基础设施心脏和肺部疾病的新危险因素拟议的补充研究的目标是。翻译家长补助金的活动并确定早期生命风险因素及其与成年后经历的其他社会心理压力源——多代人的心脏代谢问题疾病，最终支持减少高危人群中这些风险因素的工作。因此，研究目标如下：（目标1）调查种族/民族和儿童心理社会压力的地理/人口预测因素及其与社会经济地位 (SES) – 成年女性；（目标 2）确定 ACE 如何与成年女性结合起来压力经历来预测心脏代谢疾病并检查累积的程度压力导致心脏代谢疾病危险因素的种族差异；以及（目标3）了解可能减少或加剧心理社会之间关联的背景因素通过智能手机数字表型分析和收集来确定压力源和心脏代谢结果所提出的补充研究具有重要的公共卫生意义。影响。