A novel robotic wastewater analysis system to quantify opioid exposure and treatment in residential communities

一种新型机器人废水分析系统，用于量化住宅社区中阿片类药物的暴露和处理

基本信息

批准号：
10549579
负责人：
Peter R Chai
金额：
$ 17.49万
依托单位：
BIOBOT ANALYTICS, INC.
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-02-01 至 2023-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10549579
关键词：
2019-nCoV Accident and Emergency department Address Administrative Supplement American Area Back Behavior Therapy Benchmarking Biological Biological Assay Biological Markers Businesses COVID-19 COVID-19 assay COVID-19 surveillance Caring Catchment Area Chemicals Chronic Cities Clinic Clinical Cocaine Collection Communities Consumption Counseling Cross-Sectional Studies Data Detection Development Drug Screening Drug usage Emergency medical service Glucuronides HIV Infections Harm Reduction High Pressure Liquid Chromatography Hospitals Human Individual Infrastructure Intervention Journals Ketamine Life Link Location Mass Spectrum Analysis Massachusetts Measures Medical Mental Health Methamphetamine Methamphetamine use disorder Methods Mission Morbidity - disease rate Municipalities Naloxone Neighborhoods Opioid Parents Pathway interactions Patient Self-Report Pharmaceutical Preparations Pharmacologic Substance Pharmacotherapy Pharmacy facility Phencyclidine Plants Population Positioning Attribute Precision Health Preparation Prevalence Psychiatric therapeutic procedure Public Health Public Policy Recovery Reporting Resource Allocation Robotics Sampling Screening Result Sewage Site Small Business Innovation Research Grant Substance Use Disorder Surveillance Program Surveys System Systems Analysis Techniques Time Toxic effect Toxicology Trauma United States Urine Validation Vulnerable Populations Water Work base comorbidity data visualization drug development effective intervention effective therapy endo-alpha-sialidase health care service utilization high risk injection drug use innovation insight instrument interest medical schools medication nonadherence mortality multidisciplinary novel opioid epidemic opioid exposure opioid use disorder outreach parent grant peer population health prescription opioid prescription stimulants programs psychostimulant public health priorities public health relevance response sample collection stimulant use stimulant use disorder stimulant user substance use success surveillance data surveillance strategy trend wastewater epidemiology wastewater samples wastewater surveillance

项目摘要

ABSTRACT. Illicit psychostimulant use is increasing across the United States leading to significant morbidity and mortality. A 2019 cross sectional study found that individuals with self reported methamphetamine use disorder in the US has tripled since 2015. The downstream comorbidities associated with methamphetamine and other psychostimulants like cocaine, ketamine and phencyclidine result in increased healthcare utilization, medication nonadherence, infectious complications of drug use, and worsening mental health and trauma. Despite its importance, surveillance of psychostimulant use remains suboptimal; most existing surveillance strategies utilize large national self-report sampling or data from emergency department and substance use disorder clinic urine drug screens resulting in significant bias. This surveillance data is utilized to inform national public health priorities and on a community scale, allocation of resources to address substance use disorders. Wastewater-based epidemiology is a potential option to conduct population level drug surveillance. By measuring key parent compound and metabolites in wastewater networks, a prevalence estimate of drug use and trends of use over time can be visualized. By varying the location of sample collection in the wastewater network, substance use data can be described at a large wastewater treatment plant catchment area or at the community level by measuring substances at individual street level manholes. Our ongoing fast track SBIR leverages wastewater networks to develop and commercialize an opioid assay that measures both parent opioids as well as key metabolites that indicate consumption. This administrative supplement iterates on our successful parent grant by selecting four psychostimulants of

抽象的。美国各地非法精神兴奋剂的使用正在增加，导致发病率和死亡率显着增加。一个 2019 年横断面研究发现，美国自我报告的甲基苯丙胺使用障碍患者自 2015 年以来增加了两倍。与甲基苯丙胺和其他药物相关的下游合并症可卡因、氯胺酮和苯环己哌啶等精神兴奋剂会增加医疗保健利用率，服药不依从、吸毒引起的感染性并发症以及心理健康和创伤恶化。尽管很重要，但对精神兴奋剂使用的监测仍然不够理想；大多数现有的监控策略利用大规模的国家自我报告抽样或来自急诊室和药物使用的数据临床尿液药物筛查紊乱造成显着偏差。该监测数据用于通知国家公共卫生优先事项和社区范围内分配资源以解决药物滥用问题失调。基于废水的流行病学是进行人群水平药物监测的潜在选择。通过测量废水网络中的关键母体化合物和代谢物，可以估计药物的流行率使用情况和随时间的使用趋势可以可视化。通过改变样品采集的位置废水网络，可以描述大型废水处理厂集水区的物质使用数据通过在各个街道层面的沙井测量物质，在区域或社区层面进行监测。我们持续的快速 track SBIR 利用废水网络开发阿片类药物测定并将其商业化，该测定可同时测量母体阿片类药物以及指示消费的关键代谢物。本行政补充内容重复我们通过选择四种精神兴奋剂成功地资助了

项目成果

期刊论文数量（2）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Evaluation of Chemical, Biological, Radiological, Nuclear, Explosives (CBRNE) Knowledge Change and Skills Confidence Among Frontline-Line Providers During the Russia-Ukraine War.

DOI：
10.1017/dmp.2023.52
发表时间：
2023-05-09
期刊：
DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS
影响因子：
2.7
作者：
Erickson, Timothy B.;Harvin, Donell;Schmid, Alexis;Loevinsohn, Gideon;Poriechna, Anna;Martyshyn, Oleg;Kliukach, Kryrylo;Sydlowski, Meaghan;Strong, Jonathan;Kivlehan, Sean M.
通讯作者：
Kivlehan, Sean M.

Human trafficking and the growing malady of disinformation.