NICHD Cooperative Multicenter Neonatal Research Network - (UG1) Ohio State

NICHD 合作多中心新生儿研究网络 - (UG1) 俄亥俄州立大学

基本信息

批准号：
10348100
负责人：
Pablo J Sanchez
金额：
$ 27.93万
依托单位：
RESEARCH INST NATIONWIDE CHILDREN'S HOSP
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-04-01 至 2023-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10348100
关键词：
Area Child Childhood Clinical Clinical Protocols Clinical Research Collaborations Communicable Diseases Consent Dedications Discipline of obstetrics Disease Enrollment Ensure Evaluation Follow-Up Studies Funding Future Goals Gold Hospitals Individual Infant Infant Care Infection Institution Intervention Joints Lead Leadership Low Birth Weight Infant Maternal-Fetal Medicine Units Network Medical center Medicine Methodist Church Multi-Institutional Clinical Trial Multi-site clinical study Multicenter Neonatal Research Network National Institute of Child Health and Human Development Neonatal Neonatology Newborn Infant Nurseries Observational Study Ohio Outcome Patients Pediatric Hospitals Performance Principal Investigator Protocols documentation Randomized Clinical Trials Reapplication Research Research Infrastructure Resources Role Safety Sepsis Source Treatment Efficacy U-Series Cooperative Agreements United States National Institutes of Health Universities Work antimicrobial clinical care clinical center clinical infrastructure clinical research site college data acquisition design early onset experience feeding fetal follow-up high risk infant improved infant morbidity/mortality man member neonatal care neonate pediatric department perinatal medicine programs public health relevance randomized trial service delivery systems research

项目摘要

DESCRIPTION (provided by applicant): This proposal is a reapplication from the Division of Neonatology at Nationwide Children's Hospital (NCH) and The Ohio State University (OSU) to participate in the multi-center clinical program, the Eunice Kennedy Shriver NICHD Neonatal Research Network (NRN). NCH-OSU has been a member of the NRN since 2011. Pablo Sánchez, MD, Sudarchan Jadcherla, MD, and Nathalie Maitre, MD are the Principal Investigator (PI), Alternate PI, and Follow-up PI, respectively. Dr. Maitre is an important addition to the NRN team. She joins the Neonatology Division at NCH-OSU in July 2015 and has extensive experience in the assessment and follow- up of high risk infants while at Vanderbilt University. Her presence and contribution enhances our follow-up program significantly. As an NRN clinical center, NCH-OSU has the necessary academic, research and clinical infrastructure already in place that will assure continued excellence in the performance of NRN studies. The Neonatology Division at NCH-OSU has demonstrated a strong commitment to clinical research, and in this endeavor, it has the strong support of the OSU Pediatric Department and its clinical facilities, NCH and The Ohio State University Wexner Medical Center where the clinical studies pertaining to this RFA will continue to be performed. Importantly with this submission, a third sit will be added, namely the NCH NICU at Riverside Methodist Hospital (RMH), a facility that boasts the largest inborn delivery service in Columbus. In addition, the Obstetric Dept. of OSU is one of 14 centers of the NICHD Maternal-Fetal Medicine Units (MFMU), and strong collaboration between the OSU MFMU and NCH exists at all levels of clinical care and research. This partnership assures a continued source of diverse patients for clinical studies. NCH-OSU has a proven track record within the NRN, as evidenced by its well organized clinical research program with a high percentage of eligible infants consented for randomized trials and excellence in conducting the studies. The PI has extensive experience in the performance of multicenter, randomized clinical trials. By being board certified in both Neonatology and Pediatric Infectious Diseases, Dr. Sánchez will provide expertise to the NRN on issues in neonatal infectious diseases, a vexing problem among low birth weight infants.

描述（由申请人提供）：本提案是全国儿童医院 (NCH) 新生儿科和俄亥俄州立大学 (OSU) 重新申请参加多中心临床项目，尤尼斯·肯尼迪·施赖弗 (Eunice Kennedy Shriver) NICHD 新生儿研究网络(NRN) 自 2011 年以来一直是 NRN 的成员。Pablo Sánchez，医学博士、Sudarchan Jadcherla，医学博士和Nathalie Maitre 医学博士分别担任首席研究员 (PI)、候补 PI 和后续 PI。Maitre 博士是 NRN 团队的重要补充，她于 2015 年 7 月加入 NCH-OSU 新生儿科，并拥有广泛的研究经验。在范德比尔特大学期间，她在评估和随访高危婴儿方面拥有丰富的经验，她的存在和贡献极大地增强了我们作为 NRN 临床中心的随访计划。必要的学术、研究和临床基础设施已经到位，将确保 NRN 研究的持续卓越表现 NCH-OSU 的新生儿科已表现出对临床研究的坚定承诺，并且在这一努力中得到了以下机构的大力支持。 OSU 儿科及其临床设施、NCH 和俄亥俄州立大学 Wexner 医学中心将继续进行与本次 RFA 相关的临床研究，重要的是，在本次提交中，将增加第三个地点，即位于 Riverside 的 NCH NICU。卫理公会医院 (RMH) 是哥伦布最大的分娩服务机构，此外，俄勒冈州立大学产科是 NICHD 母胎医学中心 (MFMU) 的 14 个中心之一，俄勒冈州立大学与俄勒冈州立大学之间有着密切的合作。 MFMU 和 NCH 存在于临床护理和研究的各个层面，这确保了 NCH-OSU 在 NRN 内拥有良好的记录。组织了临床研究计划，有很高比例的合格婴儿同意进行随机试验，并且在进行研究方面表现出色。 PI 博士通过了新生儿学和儿科传染病方面的委员会认证，在进行多中心、随机临床试验方面拥有丰富的经验。桑切斯将为 NRN 提供有关新生儿传染病问题的专业知识，这是低出生体重婴儿中一个棘手的问题。