NICHD Cooperative Multicenter Neonatal Research Network

NICHD 多中心新生儿合作研究网络

• 批准号: 8643285
• 负责人: Pablo J Sanchez
• 金额: $ 26.76万
• 依托单位: RESEARCH INST NATIONWIDE CHILDREN'S HOSP
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8643285
• 关键词: Address; Admission activity; Affect; American; Biometry; Birth; Bronchopulmonary Dysplasia; Chronic; Clinical; Clinical Protocols; Clinical Research; Coupled; Data; Data Set; Development; Disease; Genes; Genetic; Gestational Age; Health; Health Care Costs; Healthcare Systems; Housing; Infant; Infant Care; Institution; Maintenance; Medicine; Methodology; Mission; Multicenter Neonatal Research Network; National Institute of Child Health and Human Development; Nature; Neonatal; Neonatology; Nursing Faculty; Ohio; Outcome; Patients; Pediatric Hospitals; Pediatric Research; Perinatal; Population; Population Heterogeneity; Predisposition; Premature Birth; Premature Infant; Principal Investigator; Productivity; Research; Research Design; Research Infrastructure; Research Institute; Resources; Risk; Series; Services; Site; Strategic Planning; Stress; Telemedicine; Testing; Universities; Work; adverse outcome; clinical material; feeding; fetal medicine; follow-up; genome wide association study; high risk; improved; infant death; innovation; member; multidisciplinary; premature; prevent; programs; public health relevance; response

DESCRIPTION (provided by applicant): The Division of Neonatology of Nationwide Children's Hospital and The Ohio State University submits this application to join the Eunice Kennedy Shriver NICHD Cooperative Multicenter Neonatal Research Network in response to RFA-HD-10-003. Strengths of our Institution include: 1) a truly academic Division that consists of 19 clinical faculty members with an exceptional record of clinical research, 2) a large and medically diverse population available for clinical studies with 2,197 NICU admissions in 2009 of which 615 were <= 32 weeks gestational age and 539 were <1500 grams birthweight, 3) a vibrant collaborative relationship with maternal-fetal medicine and a long and successful relationship between our institution and the NICHD MFMU, 4) a dynamic Center for Perinatal Research housed in the Research Institute, which includes a vigorous clinical research enterprise the Ohio Perinatal Research Network, and 5) a robust Institutional commitment to preventing prematurity and its complications. Indeed, preventing prematurity is the focus of NCH's strategic plan. All of these strengths will contribute greatly to NICHD NRN studies. Furthermore, our population is very receptive and agreeable to participation in clinical studies related to preterm birth. Our clinical capabilities are far reaching and include essentially every service offered to preterm neonates. We have a neonatal follow-up program that has proven to be particularly well suited to follow-up of subjects in clinical protocols. Our concept application entitled, "Developing a Personalized Medicine Approach to Preterm Infants", brings together neonatology, genetics, mathematical medicine, and biostatistics to develop a personalized medicine approach to the complications of prematurity. This concept application demonstrates our expertise in acquiring, storing and analyzing vast data sets. This expertise will be necessary for any "omic" types of studies that the NICHD NRN may undertake in the years to come. Our assets, abundant clinical material, outstanding institutional support, exceptional collegiality between MFM and neonatology, the resources of a dedicated pediatric research institute, and outstanding academic neonatologists make NCH/OSU an ideal site for the NICHD NRN.

描述（由申请人提供）：全国儿童医院新生儿学和俄亥俄州立大学提交了此申请，以加入Eunice Kennedy Shriver Nichd合作性多中心新生儿研究网络，以响应RFA-HD-HD-10-003。我们机构的优势包括：1）真正的学术部门由19名临床教师组成，具有临床研究的特殊记录，2）可用于临床研究的大量和医学上的人群，2009年有2,197个NICU入学，其中615个是< = 32周的妊娠年龄和539个<1500克出生体重，3）与母亲养育医学的充满活力的协作关系，我们的机构与NICHD MFMU之间建立了长期而成功的关系，4）研究中围产研究中心的动态研究中心Institute，其中包括俄亥俄州围产期研究网络的剧烈临床研究企业，以及5）对预防早产及其并发症的强大机构承诺。确实，防止早产是NCH战略计划的重点。所有这些优势将对NICHD NRN研究产生巨大贡献。此外，我们的人口非常容易接受，并且可以参与与早产相关的临床研究。我们的临床能力已达到遥远，基本上包括提供给早产新生儿的每项服务。我们有一个新生儿随访计划，该计划已被证明非常适合临床方案中的受试者的随访。我们的概念应用程序为“为早产者开发个性化医学方法”，汇集了新生儿学，遗传学，数学医学和生物统计学，以开发一种个性化的医学方法来使其早产。该概念应用程序展示了我们在获取，存储和分析大量数据集方面的专业知识。对于NICHD NRN在未来几年中可能进行的任何“ OMIC”类型的研究都是必要的。我们的资产，丰富的临床材料，出色的机构支持，MFM和新生儿学之间的卓越合作，专门的儿科研究所的资源以及杰出的学术新生学家使NCH/OSU成为NICHD NRN的理想场所。