NICHD Neonatal Research Network (NRN)

NICHD 新生儿研究网络 (NRN)

• 批准号: 10682973
• 负责人: Pablo J Sanchez
• 金额: $ 1.56万
• 依托单位: RESEARCH INST NATIONWIDE CHILDREN'S HOSP
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10682973
• 关键词: Acute Renal Failure with Renal Papillary Necrosis; Behavioral; Board Certification; Bronchopulmonary Dysplasia; Cardiology; Child; Childhood; Clinical; Clinical Protocols; Clinical Research; Clinical Trials; Cognitive; Collaborations; Communicable Diseases; Consent; Dedications; Discipline of obstetrics; Disparity; Doctor of Philosophy; Eligibility Determination; Enrollment; Ensure; Evaluation; Family; Funding; Goals; Healthcare; Hospitals; Individual; Infant; Infant Care; Intensive Care Units; International; Intervention; Joints; Lactation; Leadership; Longitudinal Studies; Low Birth Weight Infant; Maternal-Fetal Medicine Units Network; Medical; Medicine; Methodist Church; Mission; Multi-Institutional Clinical Trial; Multi-site clinical study; Multicenter Neonatal Research Network; National Institute of Child Health and Human Development; Neonatal; Neonatal Intensive Care Units; Neonatology; Neurology; Newborn Infant; Observational Study; Ohio; Outcome; Patient-Focused Outcomes; Patients; Pediatric Hospitals; Performance; Perinatal; Positioning Attribute; Premature Birth; Premature Infant; Principal Investigator; Productivity; Protocols documentation; Recording of previous events; Referral and Consultation; Reproducibility; Research; Research Design; Research Infrastructure; Research Institute; Research Support; Role; Safety; Source; Study Subject; Treatment Efficacy; U-Series Cooperative Agreements; United States National Institutes of Health; Universities; Vision; Work; antimicrobial; clinical care; clinical infrastructure; clinical practice; cultural equity; data acquisition; experience; extreme prematurity; feeding; fetal; follow-up; health equity; high risk infant; improved; infant morbidity; infant morbidity/mortality; innovation; neonatal care; neonatal patient; neonate; opioid exposure; patient population; pediatric department; perinatal medicine; programs; randomized trial; randomized, clinical trials; recruit; research study; systems research

PROJECT SUMMARY/ABSTRACT This proposal is a renewal application from the Division of Neonatology at Nationwide Children’s Hospital (NCH) and The Ohio State University (OSU) to participate with the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under a cooperative agreement (RFA: HD-16-020) in an ongoing multicenter clinical research program entitled the Neonatal Research Network (NRN). NCH/OSU was selected in 2011 to become one of 18 academic centers of the NRN. In 2016, NCH/OSU along with an additional affiliated neonatal intensive care unit (NICU) at Riverside Methodist Hospital (RMH) was again selected as one of the 15 centers that currently comprise the NRN. The Division of Neonatology has demonstrated a strong commitment to the NRN and will continue to support and enhance this network. Pablo Sánchez, MD, Jonathan Slaughter, MD, MPH, and Kristen Benninger, MD, MSc, are the Principal Investigator (PI), Alternate PI, and Follow-up PI, respectively. Dr. Sánchez has extensive experience in the performance of multicenter, randomized clinical trials. By being board certified in both Neonatology and Pediatric Infectious Diseases, he will provide expertise to the NRN on issues in neonatal infectious diseases and antimicrobial stewardship, vexing problems in the NICU. Dr. Slaughter has extensive experience in clinical research including clinical trial and advanced observational study design, while Dr. Benninger studies the long term outcomes of opioid-exposed infants. The Specific Aim of this proposal is to conduct multicenter clinical trials and observational studies in neonatal medicine in order to reduce infant morbidity and mortality and promote healthy outcomes. With the strong support of the Pediatric Department and Hospitals, NCH-OSU-RMH has the necessary academic and innovative clinical and research infrastructure to ensure continued excellence in the performance of NRN studies. Our Neonatology Division has a long-standing dedication to improving patient outcomes with a strong focus on health equity. We have developed innovative signature clinical programs in extreme prematurity, bronchopulmonary dysplasia, infant feeding, neonatal infectious diseases/antimicrobial stewardship, acute kidney injury, neonatal cardiology, and neonatal neurology that have positively impacted patient outcomes and positioned us as a region- al/national/international referral and consultation center. In addition, the Obstetric Dept. at OSU is one of 12 centers of the NICHD Maternal-Fetal Medicine Units (MFMU), and strong collaboration exists between the OSU MFMU and NCH at all levels of clinical care and research. This ongoing partnership ensures a continued source of diverse patients for clinical studies. NCH-OSU-RMH has a proven track record within the NRN, as evidenced by its well organized clinical research program with a substantial percentage of eligible infants consented for randomized trials and excellence in study conduct and data acquisition. Follow-up of study infants is integrated within the large Follow-up Program at NCH, and follow-up rates of these infants remain excellent with substantial departmental and divisional support.

项目摘要/摘要 该提案是全国儿童医院（NCH）新生儿学系的续签申请 和俄亥俄州立大学（OSU）参加Eunnedy Shriver国家儿童研究所 根据合作协议（RFA：HD-16-020）的健康与人类发展（NICHD） 选择了名为新生儿研究网络（NRN）的多中心临床研究计划 2016年，2016年成为NCH/OSU的18个学者之一 河滨卫理公会医院（RMH）的新生儿重症监护（NICU）再次被选为15 当前构成NRN的中心。 到NRN，并将继续支持和增强该网络。 MD，MPH和MSC医学博士Kristen Benninger是主要研究员（PI），替代PI和后续PI， 尊敬。 通过获得新生儿和小儿感染疾病的董事会认证，他将为您提供专业知识 新生儿感染疾病和抗菌管理的ISSEES NRN，在NICU中烦恼的问题。 屠宰在临床研究中具有丰富的经验 设计，而Benninger博士研究了阿片类药物的长期暴露婴儿。 建议是接触新生儿医学的多中心临床和观察性研究，以减少 婴儿的发病率和死亡率并促进健康的结果。 NCH-Opera-RMH部门和医院具有必要的学术和创新临床和研究 基础设施确保NRN研究的绩效持续卓越。 我们对健康公平的重点进行了长期以来的奉献精神 开发了极端预选的创新签名临床计划，支气管肺发育不良，婴儿 喂养，新生儿感染疾病/抗菌管理，急性肾脏损伤，新生儿心脏病学 新生儿神经病学对患者的结果产生了积极影响，并将我们定位为 AL/国家/国际推荐和咨询中心。 OSU之间存在NICHD母体养育医学单元（MFMU）和强有力的合作中心 MFMU和NCH所有级别的临床护理和研究。 NCH-OSU-RMH的不同患者在NRN中具有良好的记录 通过其组织良好的临床研究计划 随机试验和研究行为和数据获取方面的卓越表现。 在NCH的大型随访计划中，这些婴儿的随访率是重大的 部门和部门支持。