Developmental Core

发展核心

• 批准号: 10215458
• 负责人: Andrew Ddungu Kambugu
• 金额: $ 23.99万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-13 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10215458
• 关键词: AIDS related cancer; Address; Africa; Africa South of the Sahara; African; Age; Area; Award; Back; California; Caring; Clinical Research; Communicable Diseases; Country; Development; Doctor of Philosophy; Early Diagnosis; Environment; Foundations; Funding; Future; Generations; Grant; HIV; Health Sciences; Home; Individual; Institutes; Institution; International; Junior Physician; K-Series Research Career Programs; Leadership; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Mentors; Mentorship; Methodology; Modeling; Molds; Pattern; Phase; Pilot Projects; Prevention; Principal Investigator; Process; Productivity; Research; Research Methodology; Research Personnel; Research Project Grants; Research Support; Resources; San Francisco; Scientist; Stream; Time; Training; Translational Research; Uganda; United States; United States National Institutes of Health; Universities; Wages; Writing; anticancer research; base; career; career development; cohort; college; epidemiology study; experience; improved; interest; knowledge base; programs; prospective; response; skills; virus related cancer

Creating an independent scientist requires extensive training within an enriching academic environment as well as adequate salary and research support for the trainee. The period that follows didactic graduate training is particularly vulnerable in East Africa, which is also true in sub-Saharan Africa as a whole. While funding streams exist for graduate training, the region lacks comprehensive mechanisms to support junior investigators as they transition towards research independence. In the U.S., post-graduate training is often facilitated by NIH "K Award" programs at both the individual and institutional level. NIH K Awards had been unavailable to African scientists but this recently changed with the creation of the K43 Emerging Global Leader Award. Yet, there still remains a substantial challenge preparing both trainees and their home institutions to compete for a K43 Award or other career development awards. To address the need for career development in the post-graduate period, the Developmental Core of the USEAHAMRC will: Aim 1. Bolster the overall environment for career development in clinical, epidemiologic and translational research at the East African institutions of our United States-East Africa HIV- Associated Malignancy Research Center (USEAHAMRC). Aim 2. Mentor and provide protected time for our emerging African and U.S. junior scientists working in the field of HIV-associated malignancies as they develop their academic and leadership portfolio and mature towards independence. Aim 3. Award funding for pilot research projects to be conducted by emerging African or U.S scientists. Modeled on institutional K Award programs in the U.S., we will create a semi-monthly Career Development Seminar featuring emphasis on scientific writing, mentorship skills, and foundational methodologic training for all interested scholars at our participating institutions (Aim 1). By drawing upon lessons learned from K Award funding in the U.S., four emerging Ugandan principal investigators will have a substantial portion of their time supported for the conduct of research in area of HIV-associated malignancies and will be mentored to compete for funding that will propel them to the next stage of their careers (Aim 2). With the assistance from substantial institutional commitment from UCSF, we will award two or three Pilot Project Awards annually over the 5-year funding cycle for research related to the USEAHAMRC research themes, which will help us identify and mentor the next cohort of junior investigators.

创建独立科学家需要在丰富的学术环境中进行广泛的培训 以及对学员的足够薪水和研究支持。教学毕业生的时期 在东非，培训特别容易受到伤害，在整个撒哈拉以南非洲也是如此。尽管 资金流进行研究生培训，该地区缺乏支持初级的全面机制 调查人员向研究独立过渡时。在美国，研究生培训经常是 由NIH“ K奖”计划在个人和机构层面促进。 NIH K奖是 非洲科学家无法获得，但由于创建K43的新兴全球 领导奖。然而，准备学员和他们的家仍有一个重大的挑战 竞争K43奖或其他职业发展奖的机构。解决需求 在研究生时期的职业发展，USEAHAMRC的发展核心将： 目标1。加强临床，流行病学和 我们美国 - 非洲东非机构的转化研究 相关的恶性研究中心（USEAHAMRC）。 目标2。导师并为我们的新兴非洲和美国初级科学家提供受保护的时间 在艾滋病毒相关的恶性肿瘤领域工作，他们发展学术和 领导力投资组合和成熟的独立性。 AIM 3。针对新兴非洲或美国进行的试点研究项目的奖励 科学家。 在美国的机构K奖计划上，我们将创建一个半月份的职业发展 强调科学写作，指导技巧和基础方法学培训的研讨会 对于我们参与机构的所有感兴趣的学者（目标1）。通过利用从K中学到的教训 在美国颁发奖励，四名新兴乌干达首席调查员将有很大一部分 他们支持在与HIV相关的恶性肿瘤领域进行研究的时间，将是 指导的是争夺资金，这将推动他们进入职业生涯的下一阶段（AIM 2）。与 UCSF的实质机构承诺的帮助，我们将授予两个或三个试点项目 每年在5年资金周期中颁发与USEAHAMRC研究主题有关的研究的奖项， 这将帮助我们确定和指导下一个初级调查人员。