Data Core

数据核心

• 批准号: 10598774
• 负责人: Tekeda F. Ferguson
• 金额: $ 5.31万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10598774
• 关键词: AIDS related cancer; Acceleration; Address; Adherence; Africa; Area; Biochemistry; Bioinformatics; Biology; Biometry; Caring; Clinical; Clinical Informatics; Clinical Research; Collaborations; Communication; Communities; Computer software; Country; Data; Data Analyses; Data Collection; Data Management Resources; Data Security; Database Management Systems; Databases; Development; Disease; Educational workshop; Ensure; Epidemiologic Methods; Epidemiologist; Epidemiology; Equipment and supply inventories; Evaluation; Experimental Designs; Fostering; Funding; Geographic Distribution; Goals; HIV; Health Sciences; Hospitals; Human Resources; Immunology; Individual; Institution; Kaposi Sarcoma; Knowledge; Knowledge acquisition; Laboratory Study; Louisiana; Malignant Neoplasms; Manuscripts; Mentors; Modeling; Oceans; Persons; Pilot Projects; Play; Procedures; Productivity; Program Research Project Grants; Progress Reports; Protocols documentation; Public Health Schools; Publications; Quality Control; Research; Research Activity; Research Design; Research Personnel; Research Project Grants; Research Proposals; Research Support; Resource Informatics; Resources; Role; Science; Scientist; Security; Services; Site; Standardization; Statistical Data Interpretation; Statistical Methods; System; Tanzania; Teaching Hospitals; Technology; Testing; Time; Training; Translational Research; Universities; Work; Zambia; analytical tool; antiretroviral therapy; arm; career; cloud based; data integration; data integrity; data management; data sharing; design; electronic data; empowerment; experimental study; implementation science; inter-institutional; knowledge integration; member; novel; prevent; programs; sample collection; student training; tool

ABSTRACT The Data Management and Integration Core (DMIC) of the Kaposi Sarcoma (KS) in Era of Antiretroviral Therapy in Africa Program (KEAAP) is responsible for streamlining and coordinating data management, analytical procedures, statistical analysis, and bio-specimen storage and inventory in support of the research activities proposed by the KEAAP pilot and research projects. The DMIC will perform its responsibility in close collaboration with the Administrative Core and Career Developmental Core, and KEAAP investigators to ensure efficient protocol adherence and consistent application of high quality control, biosafety and data security practices. The DMIC will play a critical role in achieving KEAPP research objectives, and in supporting other funded projects and new initiatives thematically related to the KEAAP, as well as in the training of students, fellows, and new investigators within this HIV-associated malignancies program. The objective of DMIC is to develop advanced biostatistics and epidemiology capabilities at the Tanzania and Zambia partnering sites, through a shared and coordinated data collection system, with data integration from the existing research and clinical informatics resources at the three partner institutions to support the three proposed research project and other pilot projects. This will be achieved by the completion of three aims: 1) Provide biostatistics and bioinformatics solutions, expertise and support services for the design and conduct of KEAAP research projects in the areas of clinical, and laboratory studies and experiments. 2) Create standardized operating procedures, databases, and data collection tools to ensure quality standards throughout the 5-year study period for all KEAAP project arms. 3) Provide support and training to the KEAAP consortium. The DMIC will work with KEAAP investigators in designing, testing, and implementing online data collection tools and study databases using REDCap™ (Research Electronic Data Capture) to meet the specific needs of the investigators. The DMIC will perform all statistical analysis, and work with investigators in preparing presentations, manuscripts and progress reports. The DMIC will train and oversee personnel at each institution on data entry placing special emphasis on data integrity, security and confidentiality. Additional workshops will be conducted to increase capacity and shared knowledge across countries of the most up-to date advances in data management, sharing and software. Activities of the DMIC will facilitate the sharing of research findings and data among projects, increase collaborations between the researchers, and promote the development of new research proposals, thereby integrating the knowledge acquired.

抽象的 抗逆转录病毒时代的Kaposi肉瘤（KS）的数据管理和集成核心（DMIC） 非洲治疗计划（KEAAP）负责简化和协调数据管理， 分析程序，统计分析以及生物特异性存储和库存，以支持研究 KEAAP飞行员和研究项目提出的活动。 DMIC将在关闭其责任 与行政核心和职业发展核心合作，KEAAP调查人员 确保高质量控制，生物安全和数据的有效协议遵守和一致应用 安全实践。 DMIC将在实现KEAPP研究目标和支持方面发挥关键作用 其他资助的项目和新计划与KEAAP以及培训有关 该艾滋病毒相关的恶性肿瘤计划中的学生，研究员和新调查人员。目的 DMIC将在坦桑尼亚和赞比亚开发先进的生物统计学和流行病学能力 通过共享和协调的数据收集系统合作网站以及来自 三个合作伙伴机构的现有研究和临床信息资源，以支持这三个 拟议的研究项目和其他试点项目。这将通过完成三个目标来实现：1） 为设计和行为提供生物统计学和生物信息学解决方案，专业知识和支持服务 KEAAP研究项目在临床，实验室研究和实验领域。 2）创建 标准化的操作程序，数据库和数据收集工具，以确保质量标准 在所有KEAAP项目武器的5年学习期间。 3）向KEAAP提供支持和培训 财团。 DMIC将与KEAAP调查人员合作设计，测试和实施在线数据 使用REDCAP™（研究电子数据捕获）收集工具和研究数据库，以满足特定 调查人员的需求。 DMIC将执行所有统计分析，并与研究人员合作 准备演示，手稿和进度报告。 DMIC每个人都会训练和海外人员 在数据输入方面的机构特别强调数据完整性，安全性和机密性。额外的 将举办研讨会，以提高最新国家的能力和共享知识 数据管理，共享和软件的日期进展。 DMIC的活动将有助于共享 研究发现和项目之间的数据，增加研究人员之间的合作，并促进 开发新的研究建议，从而整合所获得的知识。