United States-East Africa HIV-Associated Malignancy Research Center (USEAHAMRC) for Career Development and the Prevention, Early Detection and Efficient Linkage to Care for Virus-related Cancers

美国-东非艾滋病毒相关恶性肿瘤研究中心 (USEAHAMRC)，致力于职业发展以及病毒相关癌症的预防、早期检测和有效护理联系

• 批准号: 10454919
• 负责人: Andrew Ddungu Kambugu
• 金额: $ 25.51万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-13 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10454919
• 关键词: AIDS related cancer; Address; Africa; Africa South of the Sahara; African; Award; Back; Biometry; California; Caring; Clinical; Clinical Research; Collaborations; Communicable Diseases; Country; Development; Diagnosis; Diagnostic tests; Early Diagnosis; Early treatment; Face; Foundations; Funding; General Hospitals; General Population; HIV; HIV Infections; Health; Home; Incidence; Individual; Institutes; Institution; Junior Physician; K-Series Research Career Programs; Kaposi Sarcoma; Kenya; Knowledge; Lead; Leadership; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Massachusetts; Mediating; Medical Research; Mentors; Modeling; Patients; Performance; Persons; Pilot Projects; Prevention; Prevention strategy; Primary Prevention; Principal Investigator; Prognosis; Program Development; Public Health; Research; Research Institute; Research Personnel; Research Project Grants; Research Training; Resource-limited setting; Resources; San Francisco; Science; Scientist; Screening for cancer; Secondary Prevention; Shoulder; Structure; Tanzania; Training; Translational Research; Uganda; United States; United States National Institutes of Health; United States National Library of Medicine; Universities; Viral; Work; advanced disease; anticancer research; base; career development; cervical cancer prevention; clinically relevant; data management; epidemiology study; experience; improved; interest; novel; operation; programs; prospective; research study; response; screening; tool; virus related cancer

In the field of HIV-associated malignancies, East Africa faces three intersecting problems common to resource-limited settings. First, East Africa lacks effective primary and secondary prevention strategies for cervical cancer and Kaposi’s sarcoma (KS), two of the most common cancers not only among HIV-infected persons but in the general population. Survival for both malignancies is poor due to multiple factors including lack of screening, advanced disease stage at presentation, suboptimal diagnostic tests and fragile linkage to care. Second, there is a paucity of local principal investigators to lead research related to HIV- associated cancer. Third, there are no robust research networks to study primary and secondary prevention of HIV-associated cancers in the region. To address this, eight institutions in the U.S. and East Africa will: Aim 1. Create a collaborative network of U.S.-based and East African-based scientists and institutions — the United States-East Africa HIV-Associated Malignancy Research Center (USEAHAMRC) — focused on career development and the performance of research related to prevention, early detection and efficient linkage to care for virus-related cancers; Aim 2. Support the career development of emerging African principal investigators, U.S.-based junior investigators and others in the USEAHAMRC in the performance of HIV and other virus- related cancer research; and Aim 3. Conduct novel research — led by our emerging African principal investigators — related to the prevention, early detection and efficient linkage to care for virus-related cancers. The USEAHAMRC will build on prior work in U54 CA190153 to create a network of scientists from 4 U.S. institutions (UCSF, Duke, Massachusetts General Hospital, and the National Library of Medicine) and 4 African institutions in 3 East African countries (Infectious Diseases Institute in Uganda; Moi University in Kenya; Kenya Medical Research Institute; and Muhimbili University in Tanzania) (Aim 1). We will model our career development activities after NIH-sponsored institutional mentored career development programs (Aim 2). Managed by a Developmental Core, these activities will include professional enrichment to all interested junior scientists at our participating institutions, mentoring of a select group of African and U.S.- based junior scientists to compete for career development awards, and a Pilot Project program to attract new junior scientists. Our African junior investigators will also lead two research projects (Aim 3): Project 1, A Public Health Approach to Cervical Cancer Prevention in East Africa; and Project 2, Rapid Case Ascertainment as a Tool for Epidemiologic Investigation and Efficient Linkage to Care in HIV-infected Patients Diagnosed with Kaposi Sarcoma in East Africa. A Data Management and Biostatistical Analysis Core (DMBAC) will support all of the science. Finally, an Administrative Core will oversee all operations.

在与艾滋病毒相关的恶性肿瘤领域，东非面临三个相交的问题 资源有限的设置。首先，东非缺乏有效的初级和次要预防策略 宫颈癌和Kaposi的肉瘤（KS），不仅是HIV感染的两种癌症 人，但在普通人群中。由于多种因素，两种恶性肿瘤的生存都很差 包括缺乏筛查，演讲时晚期疾病阶段，次优诊断测试和脆弱 与护理的联系。其次，当地首席研究人员很少领导与HIV有关的研究 相关癌症。第三，没有强大的研究网络来研究主要和次要预防 该地区与HIV相关的癌症的癌症。为了解决这个问题，美国和东非的八个机构将： 目标1。建立一个由美国和东非科学家和东非科学家的协作网络以及 机构 - 美国 - 非洲与HIV相关的恶性研究中心 （USEAHAMRC） - 专注于职业发展和与 预防，早期检测和有效的联系，以护理与病毒相关的癌症； 目标2。支持新兴非洲主要研究人员的职业发展，美国 useahamrc的初级调查人员和其他研究人员在艾滋病毒和其他病毒表现方面 相关的癌症研究；和 目标3。进行新的研究 - 由我们新兴的非洲主要研究人员领导 - 相关 为了预防，早期检测和有效的联系以护理与病毒相关的癌症。 USEAHAMRC将以U54 CA190153的先前工作为基础，以创建来自美国4个科学家的网络。 机构（UCSF，杜克大学，马萨诸塞州综合医院和国家医学图书馆）和4 东非3个国家的非洲机构（乌干达的传染病研究所； MOI大学 肯尼亚;肯尼亚医学研究所；坦桑尼亚的穆希比利大学（AIM 1）。我们将建模我们的 NIH赞助的机构事业发展计划后的职业发展活动 （目标2）。这些活动由发展核心管理，包括对所有人的专业丰富 有兴趣的我们参与机构的初级科学家，指导一组非洲和美国的团体 基于的初级科学家争夺职业发展奖，以及一个试点项目计划，以吸引 新的初级科学家。我们的非洲初级调查人员还将领导两个研究项目（AIM 3）：项目1， 东非的一种预防宫颈癌的公共卫生方法；和项目2，快速案例 确定作为流行病学研究的工具，并有效地连接了HIV感染的护理 东非被诊断出患有Kaposi肉瘤的患者。数据管理和生物统计分析 核心（DMBAC）将支持所有科学。最后，行政核心将监督所有操作。