Chronic Toxoplasma gondii, Pregnancy reactivation, and Perinatal Depression

慢性弓形虫、妊娠再激活和围产期抑郁

基本信息

批准号：
9382334
负责人：
Maureen Edith Groer
金额：
$ 56万
依托单位：
UNIVERSITY OF SOUTH FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-08-12 至 2022-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9382334
关键词：
Age Animals Antibodies Appearance Behavior Behavior Control Behavioral Biochemical Brain Characteristics Chorioretinitis Chronic Cicatrix Control Groups Country Cyst DNA Encapsulated Ethnic Origin Fetus Frequencies Functional disorder Generations Goals High Risk Woman Hispanics Human Immune Immunocompetent Immunoglobulin G Immunosuppression Incidence Individual Infection Inflammation Knowledge Kynurenine Lead Lesion Literature Measurable Measures Mental Depression Metabolism Migraine Moods Mothers Muscle Neuroimmune Outcome Parasites Perinatal Pharmacotherapy Placenta Plasma Population Postpartum Period Pregnancy Pregnant Women Primary Infection Reactive depression Reporting Research Retinal Risk Rodent Model Role Schizophrenia Second Pregnancy Trimester Serotyping Social support Stream Stress Suicide Symptoms Toxoplasma gondii Toxoplasmosis Tryptophan Tryptophan Metabolism Pathway Umbilical Cord Blood United States Virulent Woman Work antepartum depression behavioral study brain tissue cohort cytokine depressive symptoms fetal fetal blood high risk population immunosuppressed latent infection peripartum depression psychologic reactivation from latency relating to nervous system response seropositive socioeconomics symptomatology transmission process

项目摘要

Project Summary/Abstract Toxoplasma gondii is a ubiquitous parasite that infects one third of the world's population. It remains in a latent state, encapsulated in cysts in the brain and muscle tissue of infected hosts. Reactivation rarely occurs, and usually only when the host has become significantly immunosuppressed. However, emerging literature suggests that chronic, latent infection is not innocuous. There have been reports associating depression, schizophrenia, suicidality, unusual behaviors, and migraine headaches with T. gondii IgG titers in chronically infected individuals. In addition, a few reports suggest that T. gondii can reactivate in healthy, immunocompetent pregnant women. These relationships have not yet been studied systematically in perinatal women. This proposal will study the relationships between latent T.gondii infection and depression through pregnancy and the early postpartum in T. gondii positive Hispanic women. Hispanic women are at highest risk for the type 1 serotype and a new highly virulent strain. Studies of behavioral and mood effects of T. gondii infection in both rodent models and humans have been done, but not in perinatal women. The research team has reported a relationship between T. gondii IgG titers and depression in second trimester pregnant women. In the proposed study, the role of socioeconomics and country of origin, cytokines, and immunosuppression will be determined across pregnancy. The relationship between IgG titer and depression in the postpartum will also be studied. A T. gondii negative control group will provide comparison. The second goal is to determine the true incidence of T. gondii reactivation in pregnant women with latent T. gondii infection. Women with positive IgG titers will be followed through pregnancy for changes in titer, symptoms, and for those with retinal scars, evidence of reactivation of chorioretinitis. The third goal is to explore the possibility of live tachyzoites transiting across the placenta into the fetal blood stream in T. gondii positive women.

项目概要/摘要弓形虫是一种普遍存在的寄生虫，感染了世界三分之一的人口。它保留在一个潜伏状态，封装在受感染宿主大脑和肌肉组织的囊肿中。很少重新激活发生，并且通常仅当宿主的免疫受到显着抑制时才会发生。然而，新兴的文献表明，慢性、潜伏感染并非无害。有报道称关联抑郁症、精神分裂症、自杀倾向、异常行为和偏头痛（弓形虫 IgG 滴度）在慢性感染者中。此外，一些报告表明弓形虫可以在健康、免疫功能健全的孕妇。这些关系尚未得到系统研究围产期妇女。该提案将通过以下方式研究潜伏弓形虫感染与抑郁症之间的关系弓形虫阳性的西班牙裔妇女怀孕和产后早期。西班牙裔女性比例最高 1 型血清型和新的高毒力菌株的风险。 T 的行为和情绪影响的研究。已经在啮齿动物模型和人类中进行了弓形虫感染，但尚未在围产期妇女中进行过感染。这研究小组报告了弓形虫 IgG 滴度与妊娠中期抑郁症之间的关系孕妇。在拟议的研究中，社会经济学和原籍国、细胞因子和免疫抑制将在整个怀孕期间确定。 IgG滴度与抗体滴度的关系还将研究产后抑郁症。弓形虫阴性对照组将提供比较。第二个目标是确定患有潜伏性弓形虫的孕妇中弓形虫再激活的真实发生率。弓形虫感染。 IgG 滴度呈阳性的女性将在整个怀孕期间跟踪滴度变化，症状，对于那些有视网膜疤痕的人，有脉络膜视网膜炎重新激活的证据。第三个目标是探索活速殖子穿过胎盘进入胎儿的可能性弓形虫阳性女性的血流。