Collaborative Human Tissue Network

协作人体组织网络

• 批准号: 9236160
• 负责人: WILLIAM E. GRIZZLE
• 金额: $ 74.06万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9236160
• 关键词: Accreditation; Address; Advocate; Affect; African American; Alabama; Aliquot; American; Archives; Area; Autopsy; Big Data; Body Fluids; Canada; Caring; Clinical; Clinical Research; Collaborations; Collection; Common Neoplasm; Complex; Computerized Medical Record; Coupled; DNA; Data; Development; Diagnosis; Diagnostic; Diagnostic Procedure; Disease; Doctor of Philosophy; Education; Ensure; Environment; Ethics; Exhibits; Family; Freezing; Fresh Tissue; Funding; Future; Goals; Grant; Guidelines; Healthcare; Hospitals; Human; Individual; Informatics; Information Systems; Information Technology; Institution; International; Internet; Lead; Leadership; Link; Liquid substance; Malignant Neoplasms; Medical; Messenger RNA; Minority; Modeling; Modification; Needle biopsy procedure; Neoplasm Metastasis; Network-based; Outcome; Paraffin; Participant; Pathologist; Patients; Play; Policies; Primary Neoplasm; Privacy; Procedures; Process; Protocols documentation; Provider; Pyroxylin; Quality Control; Recording of previous events; Recruitment Activity; Research; Research Personnel; Research Support; Resources; Retrieval; Role; Sampling; Secure; Site; Social Welfare; Source; Specimen; System; Techniques; Testing; Therapeutic Intervention; Tissue Banks; Tissue Microarray; Tissue Sample; Tissues; Training; Translational Research; United States; Universities; anticancer research; base; biobank; certificate program; college; data acquisition; follow-up; high resolution imaging; human tissue; improved; innovation; inter-individual variation; interoperability; neoplastic; novel; novel diagnostics; novel strategies; operation; personalized medicine; programs; public health relevance; quality assurance; repository; response; screening; social; success; tumor; tumor registry

DESCRIPTION (provided by applicant): The Collaborative Human Tissue Network is a continuation of a successful program to increase the supply and quality of human tissues to support research in cancer. The University of Alabama at Birmingham (UAB), as the Southern Division (SD) of the CHTN, has participated effectively in all CHTN operations at the national level since 1987. The policies and guidelines that have been established have resulted in a dependable source for cancer researchers of a wide range of expertly processed, well-characterized and high quality human tissues with associated histopathologic and demographic data. New challenges to biorepository operations are emerging, however. The current advances in cancer research, including the issues surrounding research into personalized medicine, have resulted in an increase in demand for tissue samples and more complex requests. Concurrently, changes in medical care, such as preoperative therapy, use of high resolution imaging instead of tissue diagnoses, as well as a changing regulatory environment are affecting tissue collections. The leadership team of the SD has taken a proactive stance to meet the future needs of cancer investigators. (1) Enhancement of operations through recruitment of additional participating sites; increased use of archival paraffin blocks for metastatic lesions and untreated primary tumors; use of novel techniques, including nitrocellulose blots, for obtaining aliquots of small tissue specimens; and development of a rapid autopsy program. These are accompanied by increased education of investigators as to use of alternative tissues (e.g., autopsy, paraffin blocks) and to specimen limitations; (2) Enhancement of quality assurance and quality control through participation in external accreditation processes; and (3) Enhancement of the ethical and regulatory stance through expansion of utilization of patient advocates. The informatics system is critical to all biorepository functions and the SD proposes development of an Investigators' IT system that utilizes new-era interoperability and linked big-data systems. It als proposes an increased emphasis on training and proficiency testing in IT systems, coupled with greater utilization of the Web for access to and training in SOPs. The SD reaffirms its commitment to the operations of the CHTN as a whole. In addition to ongoing involvement at the leadership level, it continues significant collaborative efforts with individual divisions, including supplying tissues for microarrays and beta-testing of modifications of the current IT system. Since 2008, the SD has provided 20,287 fresh, frozen and fixed human aliquots to 264 investigators. Notably, within the CHTN network it provides complex specimens including aliquots of tissue processed within 30 minutes of collection; macrodissected paraffin and frozen tissues and mRNA/DNA samples as well as detailed clinical information and follow-up to investigators. It is one of the leading providers of fresh tissue samples and body fluids and the leading provider of samples from African-American patients.

描述（由申请人提供）：协作人体组织网络是一项成功计划的延续，旨在增加人体组织的供应和质量以支持癌症研究。阿拉巴马大学伯明翰分校 (UAB) 作为 CHTN 的南部分部 (SD)，自 1987 年以来一直有效参与国家层面的所有 CHTN 运营。已制定的政策和指导方针为癌症研究人员对各种经过专业处理、特征良好和高质量的人体组织以及相关的组织病理学和人口统计数据进行了研究。然而，生物样本库运营面临的新挑战正在出现。当前癌症研究的进展，包括围绕个性化医疗研究的问题，导致对组织样本的需求增加和更复杂的要求。与此同时，医疗保健的变化，例如术前治疗、使用高分辨率成像代替组织诊断，以及不断变化的监管环境正在影响组织采集。 SD 的领导团队采取了积极主动的立场，以满足癌症研究人员的未来需求。 (1) 通过招募更多参与地点来加强运营；增加使用档案石蜡块治疗转移性病变和未经治疗的病灶 原发性肿瘤；使用新技术（包括硝基纤维素印迹）来获取小组织样本的等分试样；并开发快速尸检程序。这些伴随着对研究人员关于替代组织的使用（例如尸检、石蜡块）和样本限制的教育的增加； (2) 通过参与外部认可过程加强质量保证和质量控制； (3) 通过扩大患者倡导者的利用来加强道德和监管立场。信息学系统对于所有生物样本库功能至关重要，SD 建议开发一个利用新时代互操作性和链接大数据系统的研究人员 IT 系统。它还建议更加重视 IT 系统的培训和能力测试，同时更多地利用网络来访问 SOP 并进行培训。 SD 重申其对 CHTN 整体运营的承诺。除了领导层的持续参与外，它还继续与各个部门进行重大合作，包括为微阵列提供组织以及对当前 IT 系统的修改进行 Beta 测试。自 2008 年以来，SD 已向 264 名研究人员提供了 20,287 份新鲜、冷冻和固定的人体等分样品。值得注意的是，在 CHTN 网络内，它提供复杂的样本，包括在采集后 30 分钟内处理的组织等分试样；宏观解剖的石蜡和冷冻组织和 mRNA/DNA 样本以及详细的临床信息和对研究人员的随访。它是新鲜组织样本和体液的领先提供商之一，也是非裔美国患者样本的领先提供商。