Tissue Resource/Molecular Analysis/Immunopathology

组织资源/分子分析/免疫病理学

基本信息

批准号：
7658256
负责人：
WILLIAM E. GRIZZLE
金额：
$ 12.93万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-08-01 至 2009-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7658256
关键词：
Acceleration Aliquot Animal Disease Models Animal Model Animals Appendix Applications Grants Area Authorization documentation Autopsy Benign Biological Assay Biological Markers Biometry Biopsy Cells Characteristics Clinical Clinical Treatment Collaborations Collection Communication Complex Condition Cooperative Human Tissue Network Core Facility Data Databases Dermatologic Dermatologist Development Diagnosis Diagnostic Diagnostic Services Disease Effectiveness Ensure Equipment and supply inventories Extramural Activities Facility Construction Funding Category Flow Cytometry Freezing Gene Chips Genes Health Insurance Portability and Accountability Act Health Services Research Histology Hospitals Human Human Pathology Human Resources Image Immunoelectron Microscopy Immunohistochemistry In Situ Hybridization Individual Informed Consent Investigational Therapies Laboratories Lasers Lesion Light Link Measures Methods Microdissection Microscopic Molecular Analysis Molecular Target Monitor Operative Surgical Procedures Other Genetics Outcome Paraffin Pathologic Pathologist Pathology Patients Phase Physiology Pilot Projects Polymerase Chain Reaction Preparation Prevention strategy Privacy Procedures Process Proteins Protocols documentation Publishing Quality Control Radical Mastectomy Range Reagent Recording of previous events Research Research Ethics Committees Research Personnel Research Project Grants Resources Rodent Sampling Schedule Services Skin Slide Social Welfare Source Specimen Standardization Standards of Weights and Measures Support of Research Surrogate Endpoint System Technical Expertise Techniques Technology Test Result Testing Therapeutic Time Tissue Banking Tissue Banks Tissue Microarray Tissue Model Tissue Sample Tissues Training Transfection Work animal tissue base caN protocol computerized cost data management design discount disorder control experience experimental analysis human disease human tissue immunopathology improved in vivo member novel programs prospective quality assurance skin disorder success tissue preparation tissue processing tissue resource

项目摘要

DESCRIPTION (provided by applicant): The Tissue Resource, Molecular Analysis and Immunopathology Core Facility has extensive experience in collecting, processing, storing/banking, and distributing a wide range of tissues and controls to support the research of the Skin Diseases Research Core Center (SDRC) members. Fresh, frozen and paraffin preparations of tissues can be supplied as well as unstained tissue slides, tissue matrix arrays, microdissected tissue components, as well as histology services. The Core also can provide investigators with access to methods of morphological and molecular analysis that are difficult for individual projects to support efficiently. Primarily the Core provides light microscopic and immunocytochemical interpretation of animal and human tissues and cytologic materials including methods to detect gene products within transfected cells and adjacent tissues. Investigators have access to sophisticated techniques usually available only for human pathology, including immunoelectron microscopy and special histology services such as computerized morphometric analysis (CAS200 and BLISS systems) and in situ hybridization. The involvement of dedicated diagnostic pathologists ensures that all assays are performed on optimally collected, processed and diagnosed tissue components. Centrally performed procedures free investigators from duplication of basic work, allowing more productive work with the available resources and acceleration of experimental timetables. The Core works closely with the biostatistical personnel so that clinical/demographic information can be linked easily with tissue specimens. The Core will support all projects of the SDRC and its services will be available to all SDRC members. In addition, its costs will be waived for all pilot projects and for the collection of preliminary data to support grant applications. Depending on demands for services and remaining resources, the current resources requested will permit about a 30% discount below costs of services to SDRC members.

描述（由申请人提供）：组织资源，分子分析和免疫病理学核心设施在收集，加工，储存/银行业以及分发广泛的组织和控制方面具有丰富的经验，以支持皮肤疾病疾病研究核心中心（SDRC）成员的研究。可以提供组织的新鲜，冷冻和石蜡制剂，以及未染色的组织载玻片，组织基质阵列，微切除的组织成分以及组织学服务。核心还可以为研究人员提供访问形态和分子分析方法，这很困难个人项目有效地支持。主要是核心提供光显微镜和对动物和人体组织以及细胞学材料的免疫细胞化学解释，包括在转染细胞和相邻组织中检测基因产物的方法。研究人员可以使用通常仅适用于人类病理学的复杂技术，包括免疫电子显微镜和特殊的组织学服务，例如计算机化形态计量学分析（CAS200和Bliss Systems）以及原位杂交。专用诊断病理学家的参与确保所有测定均在最佳收集，处理和诊断的组织成分上进行。中央执行的程序免费调查人员不得不重复基本工作，从而使可用资源和实验时间表的加速性更加有效。核心与生物统计人员紧密合作，以便可以轻松地将临床/人口统计信息与组织标本联系起来。核心将支持SDRC的所有项目，其服务将向所有SDRC成员提供。此外，所有试点项目和收集初步数据以支持赠款应用程序的费用将被免除。根据对服务和剩余资源的需求，当前要求的资源将允许低于SDRC成员的服务费用约30％。