SUBSTANCE P AND THE PATHOGENESIS OF CRYPTOSPORIDIOSIS IN AIDS

P 物质与艾滋病隐孢子虫病的发病机制

• 批准号: 7165077
• 负责人: PREMA ROBINSON
• 金额: $ 5.25万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-01 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7165077
• 关键词: Primates; animal colony

DESCRIPTION (provided by applicant): This application requests funding for the TNPRC for the five-year period beginning May 1, 2003 through April 30, 2008. Funds will be used to support the administration, operations, veterinary resources, and scientific research resources of the Center. Additional funds to support pilot research projects and colony-health-related research resource projects are also requested. The research program at the TNPRC has been focused on infectious disease research for close to three decades. Although the majority of the Center's research efforts are devoted to infectious disease, there are also rapidly expanding programs in gene therapy and assisted reproductive technologies (ART). The infectious disease program currently focuses on AIDS, Malaria Microsporidial diseases, and Lyme disease. These are multidisciplinary studies involving investigators in numerous Divisions at the TNPRC as well as collaborators outside the Center. The studies cover the spectrum from transmission, diagnosis and pathogenesis, development of vaccine strategies and chemotherapeutic treatments, and pathologic lesions to gene sequences. In addition, the development of the gene therapy program allows for novel approaches to the treatment of many types of disease and preclinical modeling of a variety of gene therapy modalities. The last five years, and particularly the last year, have seen significant changes at the Center, following the retirement of Dr. Peter Gerone and the naming of Dr. Andrew Lackner as the new Director. Since October 1, 2001 when Dr. Lackner became Director, leadership in several of the Divisions has changed, new Divisions have been formed, and the business office (now Administrative Services) has begun reorganization. The result is a Center that now places more emphasis on research programs and which has experienced a 50% growth in its grant portfolio. These changes have been facilitated by a very helpful and collegial host institution. The new organizational structure and leadership team at the TNPRC and recent successes in obtaining grant funding and attracting outside collaboration suggest that the Center is poised for a period of significant growth and improvement.

描述（由申请人提供）： 本申请请求为 TNPRC 提供从 2003 年 5 月 1 日到 2008 年 4 月 30 日的五年期资金。资金将用于支持该中心的行政、运营、兽医资源和科学研究资源。 还要求提供额外资金来支持试点研究项目和与蜂群健康相关的研究资源项目。 近三十年来，TNPRC 的研究项目一直专注于传染病研究。 尽管该中心的大部分研究工作致力于传染病，但基因治疗和辅助生殖技术（ART）方面的项目也在迅速扩大。 传染病项目目前重点关注艾滋病、疟疾、微孢子虫病和莱姆病。 这些是多学科研究，涉及 TNPRC 多个部门的研究人员以及中心外的合作者。 这些研究涵盖了从传播、诊断和发病机制、疫苗策略和化疗治疗的开发、病理病变到基因序列等各个方面。 此外，基因治疗计划的发展允许采用新方法来治疗多种类型的疾病以及各种基因治疗方式的临床前建模。 在 Peter Gerone 博士退休和任命 Andrew Lackner 博士为新主任之后，过去五年，特别是去年，该中心发生了重大变化。 自 2001 年 10 月 1 日 Lackner 博士就任主任以来，几个部门的领导层发生了变化，新的部门已经成立，业务办公室（现在的行政服务部）也开始重组。 结果是，该中心现在更加重视研究项目，其拨款组合增长了 50%。 这些变化是由一个非常乐于助人的学院主办机构推动的。 TNPRC 的新组织结构和领导团队以及最近在获得赠款资金和吸引外部合作方面取得的成功表明，该中心已准备好迎接一段显着增长和改进的时期。