HORNET Center for Autonomic Nerve Recording and Stimulation Systems (CARSS)

HORNET 自主神经记录和刺激系统中心 (CARSS)

基本信息

批准号：
10706620
负责人：
Ellis Meng
金额：
$ 47.75万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-23 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10706620
关键词：
3-Dimensional Address Adopted Ally Architecture Autonomic nervous system disorders Biocontrols Clinical Complement Custom Diameter Elasticity Electrodes Equilibrium Film Foreign Bodies Health Hypertension Immune response Implant Individual Inflammatory Bowel Diseases Lead Learning Measures Medical Medicine Memory Metals Methods Microfabrication Molds Nerve Nerve Fibers Non-Insulin-Dependent Diabetes Mellitus Operative Surgical Procedures Perineuriums Peripheral Peripheral Nerves Peripheral Nervous System Polymers Process Recording of previous events Research Rheumatoid Arthritis Scheme Shapes Site Structure Surgical sutures System Testing Thick Thinness Welding autonomic nerve bioelectronics cost design fabrication flexibility instrument interest manufacture manufacturing technology miniaturize minimally invasive neural novel open source parylene parylene C polydimethylsiloxane preservation tool wound

项目摘要

Implanted leads are critical for direct interfaces to the peripheral nervous system and have been used clinically since the 1960s. Even so, no open-architecture or open-source leads are available for autonomic nerve stimulation and recording. This is especially a problem for interfacing with soft, small diameter nerves measuring 1 mm or less. Since these are of great interest as targets in bioelectronic medicine, NEST 4 will introduce a new open-architecture nerve interface based on a helical cuff format. This cuff addresses the limitations of downscaling traditional materials and fabrication methods for polydimethylsiloxane-based cuffs and instead adopts a different scheme to achieve practical nerve cuffs using a composite Parylene C-PDMS structure. The CARSS helical microfabricated cuff uses soft polymers and thin film electrodes to achieve a miniaturized cuff form factor. The contra-rotational helical cuff design is achieved by post-processing the Parylene electrode array using a thermoforming process to achieve the final three-dimensional shape. The helical design is self- sizing and self-closing which avoids the need for sutures. The cuff is accompanied by a minimally invasive, custom endoscopic tool that will simplify surgery and allow access to deeper autonomic nerve branches. In NEST 4, the Parylene helical cuff will be developed, benchtop tested, and demonstrated with the surgical placement tool, paving the way for a widely accessible cuff for smaller nerves in clinical bioelectronic medicine research.

植入导线对于与周围神经系统的直接连接至关重要，并已在临床上使用自20世纪60年代以来。即便如此，仍然没有可用于自主神经的开放架构或开源线索刺激和记录。对于与软的、小直径的神经连接测量来说，这尤其是一个问题 1毫米或更小。由于这些作为生物电子医学的靶标引起了极大的兴趣，NEST 4 将引入一种新的基于螺旋袖口形式的开放式结构神经接口。该袖带解决了以下限制缩小聚二甲基硅氧烷袖口的传统材料和制造方法，取而代之采用不同的方案，使用复合 Parylene C-PDMS 结构实现实用的神经袖带。 CARSS 螺旋微加工袖带采用软聚合物和薄膜电极来实现微型化袖口形状因素。对转螺旋袖口设计是通过对聚对二甲苯电极进行后处理来实现的阵列使用热成型工艺来实现最终的三维形状。螺旋设计是自尺寸调整和自动闭合，无需缝合。袖带附有微创、定制的内窥镜工具将简化手术并允许进入更深的自主神经分支。在 NEST 4 中，将开发聚对二甲苯螺旋袖口、进行台式测试并通过外科手术进行演示放置工具，为临床生物电子医学中较小神经的广泛使用袖带铺平了道路研究。