A Technology Resource for Polymer Microelectrode Arrays

聚合物微电极阵列的技术资源

基本信息

批准号：
10019422
负责人：
Ellis Meng
金额：
$ 114.64万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-30 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10019422
关键词：
Address Adoption BRAIN initiative Behavioral Brain Caliber Chronic Clinical Communities Custom Data Devices Documentation Electrodes Electrophysiology (science)Ensure Evaluation FDA approved Feedback Goals Grant Histology Imaging technology Implant Masks Mechanics Metals Methodology Microelectrodes Modeling Monitor Neurosciences Neurosciences Research Operative Surgical Procedures Outcome Performance Polymers Printed Media Process Property Quality Control Rattus Recording of previous events Reproducibility Research Research Personnel Resources Running Semiconductors Services Silicon Site Structure Surface Surface Properties Techniques Technology Testing Time Tissues Training Training Activity Vertebral column Work base cost density design digital media dissemination research experimental study flexibility high standard implantation in vivo instructor interest medical implant meetings metal oxide nervous system disorder neuroprosthesis neurotechnology next generation optical imaging optogenetics parylene parylene C prototype quality assurance relating to nervous system symposium testing services translational neuroscience web site

项目摘要

The purpose of this proposal is to disseminate polymer microelectrode arrays and promote their integrated into neuroscience research practice. Such polymer neural interfaces are mechanically compliant to promote stability of the device-tissue interface and versatile in that both surface and penetrating electrode arrays can be produced with the same technology. To accomplish their dissemination and integration, a resource will be created that offers the ability to customize electrode designs for their applications that are compatible with other recording and stimulation technologies and imaging technologies. The state-of-the-art polymer probes with high channel count will be made available to select users through project proposals selected with the input of a steering committee and to the broader community as prototypes on shared multi-project processing runs. Importantly, devices produced through user engagement will be functionally tested and ready to implant. The multi-project wafer processing runs will allow for small numbers of custom devices from multiple users to be produced on a single mask set which will allow users to debug and perform design adjustments and allow the resource to efficiently utilize wafer real estate. The resource also offers a testing service to validate electrode arrays made by external users. The successful in vivo implementation of interface technologies is dependent of their repeatable construction and reliable performance; these may be difficult to attain in small batch prototypes and even in commercially produced devices because of lack of testing capabilities or expertise. Device testing services will ensure rigor, reproducibility, and transparency for the benefit of the user community. The testing approach will be comprehensive, beginning at the materials level and progressing to the interface, interconnections, and packaging. Testing will include techniques that examine surface properties, material properties, mechanical performance, electrical and electrochemical performance, and lifetime testing. As needed, testing will be tailored for each project as dictated by its end use requirements. The testing methodologies will be rigorously documented and also disseminated. To facilitate adoption of technologies by users, the resource will offer onsite training on how to implement electrode arrays in vivo in rat. The resource seeks to enable BRAIN Initiative investigators and the broader community to achieve large scale recordings that will impact fundamental neuroscience research and next generation neuroprosthetic platforms for the treatment of multiple neurological disorders and conditions.

该提案的目的是传播聚合物微电极阵列并促进其应用融入神经科学研究实践。这种聚合物神经接口在机械上符合要求，可促进设备-组织界面的稳定性，并且在表面和组织界面上均具有多功能性可以用相同的技术生产穿透电极阵列。为了完成他们的传播和集成，将创建一种资源，提供定制电极的能力其应用程序的设计与其他记录和刺激技术兼容，成像技术。将提供最先进的高通道聚合物探针通过根据指导委员会的意见选定的项目提案来选择用户，并广泛征求社区作为共享多项目处理运行的原型。重要的是，通过生产的设备用户参与度将经过功能测试并准备好植入。多项目晶圆加工运行将允许在单个掩模组上生产来自多个用户的少量定制设备这将允许用户调试和执行设计调整，并允许资源有效利用晶圆房地产。该资源还提供测试服务来验证外部用户制作的电极阵列。这接口技术在体内的成功实施取决于其可重复的构造且性能可靠；这些可能很难在小批量原型中实现，甚至在由于缺乏测试能力或专业知识而商业生产的设备。设备测试服务将确保严谨性、可重复性和透明度，以造福用户社区。测试方法将是全面的，从材料层面开始一直到界面，互连和封装。测试将包括检查表面特性、材料的技术性能、机械性能、电气和电化学性能以及寿命测试。作为根据需要，测试将根据每个项目的最终使用要求进行定制。测试方法将被严格记录并传播。为了促进用户采用技术，该资源将提供有关如何使用技术的现场培训在大鼠体内实施电极阵列。该资源旨在使 BRAIN Initiative 研究人员能够更广泛的社区实现将影响基础神经科学的大规模记录用于治疗多种神经系统疾病的研究和下一代神经假体平台和条件。