Clinical and Translational Science Collaborative of Northern Ohio, Catalyzing Linkages to Equity in Health (CLE Health)

北俄亥俄州临床和转化科学合作组织，促进健康公平的联系 (CLE Health)

• 批准号: 10704417
• 负责人: GRACE A MCCOMSEY
• 金额: $ 807.81万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-02 至 2030-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10704417
• 关键词: Academia; Acceleration; Address; African American population; Appointment; Award; Chronic; Chronic Care; Chronic Disease; Cities; Clinic; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Communities; Data; Devices; Diagnostic tests; Disadvantaged; Discipline; Disparity; Dissemination and Implementation; Diverse Workforce; Economics; Effectiveness; Elderly; Elements; Ensure; Environmental Risk Factor; Equity; Ethics; Faculty; Federally Qualified Health Center; Foundations; Funding; Generations; Goals; Grant; Growth; HIV; Health; Healthy Eating; Heart failure; Hispanic Populations; Hypertension; Industry; Infant Mortality; Information Dissemination; Institution; Intervention; Investments; Laboratories; Leadership; Lesbian Gay Bisexual Transgender Queer; Life Expectancy; Link; Medical; Medical center; Medicine; Methods; Minority Groups; Mission; Non-Insulin-Dependent Diabetes Mellitus; Ohio; Outcome; Participant; Patients; Persons; Pharmaceutical Preparations; Play; Population; Positioning Attribute; Privatization; Procedures; Process; Public Health; Public Health Informatics; Rehabilitation device; Research; Research Personnel; Resource-limited setting; Resources; Role; Rural; Safety; Services; Site; Solid; Special Population; Structural Racism; System; Technology; Testing; Training; Training Programs; Training and Education; Translation Process; Translational Research; Underrepresented Minority; Underrepresented Populations; United States Department of Veterans Affairs; Universities; University Hospitals; Vulnerable Populations; Work; Workforce Development; clinical practice; collaborative environment; community engagement; community setting; design; disparity elimination; disparity gap; experience; health disparity; health equity; health equity promotion; high risk population; implementation strategy; improved; innovation; medical schools; next generation; novel; novel strategies; novel therapeutics; opioid mortality; point-of-care diagnostics; poor health outcome; primary care practice; programs; recruit; research clinical testing; rural area; rural dwellers; social; sociocultural determinant; structural determinants; success; translational research program; translational scientist

PROJECT SUMMARY/ABSTRACT For the past 15 years, the Clinical and Translational Science Collaborative (CTSC) at Case Western Reserve University (CWRU) has linked clinical and translational research efforts at five independent institutions— CWRU, Cleveland Clinic, MetroHealth System, University Hospitals of Cleveland, and Louis Stokes Cleveland Veterans Affairs Medical Center. Two new partners (University of Toledo School of Medicine and Northeast Ohio Medical University) are now being added to extend the CTSC’s reach across Northern Ohio. The CWRU CTSC has a strong track record of enhancing the quantity and quality of Clinical and Translational Science (CTS) among our partners by facilitating novel research paradigms, technologies, and training. Our CTSC has developed a new generation of researchers, enhanced collaborations among investigators, streamlined discovery by building partnerships among industry and community and organizational partners, and facilitated many successful entrepreneurial startups. Building on this solid foundation, the CWRU CTSC proposes an expanded focus on health equity, reflected in the project theme Catalyzing Linkages to Equity in Health (CLE Health). Social, economic, and environmental disadvantages are linked to poor health outcomes and lead to disparities in life expectancy, infant mortality, and rates of chronic conditions. Minority groups are often underrepresented in clinical trials as well, meaning there can be insufficient data for understanding the effectiveness or safety of new drugs, procedures, or health interventions for different populations. The overall goals of this project are to 1) understand the fundamental barriers to optimal recruitment of underrepresented groups in clinical trials and test and scale interventions aimed at breaking down these barriers to diversify study engagement, 2) facilitate and expedite innovation in multicenter clinical and translational research by fully integrating community and stakeholder partners and ensuring that this research represents the experiences of all and results in health improvements for all, 3) disseminate and implement novel and responsive research programs across clinical and community settings to advance access to health interventions that aim to promote health equity, and 4) create and disseminate inclusive and high impact educational and training programs for translational research professionals of all disciplines and levels, both in clinical and community settings. The CTSC has designed a Strategic Management Core and six CTS research and training Elements to accomplish these goals: Workforce Development, Community & Stakeholder Engagement, Resources & Services, CTS Pilot, Health Informatics, and CTS Research Program. We are committed to innovative and collaborative practice and dissemination of results so that everyone in Northern Ohio—and beyond—can benefit from advances in CTS in our programs and discoveries.

项目概要/摘要 在过去 15 年里，凯斯西储大学的临床与转化科学合作组织 (CTSC) 大学 (CWRU) 将五个独立机构的临床和转化研究工作联系起来—— CWRU、克利夫兰诊所、MetroHealth System、克利夫兰大学医院和 Louis Stokes Cleveland 退伍军人事务医疗中心。两个新合作伙伴（托莱多大学医学院和东北大学） 俄亥俄医科大学 (Ohio Medical University) 现已加入，以扩大 CTSC 的覆盖范围至俄亥俄州北部。 CTSC 在提高临床和转化科学的数量和质量方面拥有良好的记录 (CTS) 通过促进新颖的研究范式、技术和培训，与我们的合作伙伴建立了联系。 培养新一代研究人员，加强研究人员之间的合作，简化 通过在行业、社区和组织合作伙伴之间建立伙伴关系来发现，并促进 在此坚实的基础上，CWRU CTSC 提出了一个 扩大对健康公平的关注，这反映在项目主题“促进健康公平的联系”（CLE 健康）。社会、经济和环境劣势与不良的健康结果有关，并导致 预期寿命、婴儿死亡率和慢性病发病率方面的差异往往存在于少数群体中。 在临床试验中的代表性也不足，这意味着可能没有足够的数据来理解 新药物、程序或健康干预措施对不同人群的有效性或安全性。 该项目的目标是 1) 了解对代表性不足的人员进行最佳招聘的根本障碍 临床试验、测试和规模干预小组旨在打破这些障碍，实现多元化 研究参与，2) 促进和加快多中心临床和转化研究的创新 充分整合社区和利益相关者合作伙伴，并确保这项研究代表了 所有人的经验和改善所有人健康的结果，3) 传播和实施新的和 跨临床和社区环境的响应式研究计划，以促进获得健康 旨在促进健康公平的干预措施，以及 4) 创造和传播包容性和高影响力 为所有学科和水平的转化研究专业人员提供教育和培训计划 CTSC 设计了战略管理核心和六项 CTS 研究。 和培训要素来实现这些目标：劳动力发展、社区和利益相关者 参与、资源和服务、CTS 试点、健康信息学和 CTS 研究计划。 致力于创新和协作实践以及成果传播，以便北部地区的每个人 俄亥俄州及其他地区可以从我们的项目和发现中 CTS 的进步中受益。

项目成果

Prevalence of neuromyelitis optica spectrum disorder in the United States.

美国视神经脊髓炎谱系疾病的患病率。

• 发表时间: 2024-01-27
• 作者: Briggs, Farren Bs;Shaia, Jacqueline
• 通讯作者: Shaia, Jacqueline

New-onset autoimmune disease after COVID-19.

COVID-19 后新发的自身免疫性疾病。

• 发表时间: 2024
• 作者: Hileman, Corrilynn O;Malakooti, Shahdi K;Patil, Nirav;Singer, Nora G;McComsey, Grace A
• 通讯作者: McComsey, Grace A

Does rickets carry an increased risk of osteomyelitis and septic arthritis? An aggregated electronic health record data study.

佝偻病是否会增加患骨髓炎和化脓性关节炎的风险？

• 发表时间: 2024-02-19
• 作者: Lavu, Monish S;Van Dorn, Chloe;Bobak, Lukas;Burkhart, Robert J;Kaelber, David C;Mistovich, R Justin
• 通讯作者: Mistovich, R Justin

A Call to Support Informatics Curricula in U.S.-Based Residency Education.

呼吁支持美国住院医师培训中的信息学课程。

• 发表时间: 2023-10
• 影响因子: 2.9
• 作者: You, Jacqueline G;Samal, Lipika;Leung, Tiffany I;Dharod, Ajay;Zhang, Haipeng M;Kaelber, David C;Mishuris, Rebecca G
• 通讯作者: Mishuris, Rebecca G

A Cluster Randomized Trial of Primary Care Practice Redesign to Integrate Behavioral Health for Those Who Need It Most: Patients With Multiple Chronic Conditions.

重新设计初级保健实践的集群随机试验，为最需要的人（患有多种慢性病的患者）整合行为健康。

• 发表时间: 2023
• 影响因子: 4.4
• 作者: Littenberg, Benjamin;Clifton, Jessica;Crocker, Abigail M;Baldwin, Laura;Bonnell, Levi N;Breshears, Ryan E;Callas, Peter;Chakravarti, Prama;Clark/Keefe, Kelly;Cohen, Deborah J;deGruy, Frank V;Eidt;Elder, William;Fox, Cheste
• 通讯作者: Fox, Cheste