The Environmental Determinants of Diabetes in Youth: Washington Clinical Center

青少年糖尿病的环境决定因素：华盛顿临床中心

基本信息

批准号：
8072282
负责人：
William A. Hagopian
金额：
$ 13.4万
依托单位：
PACIFIC NORTHWEST RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-08-10 至 2011-08-09
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8072282
关键词：
15 year old 4 year old Accounting Area Autoantibodies Autoimmune Diabetes Autoimmune Diseases Autoimmunity Beta Cell Biological Blood specimen C-Peptide Candidate Disease Gene Cell Communication Child Childhood Clinical Cohort Studies Collaborations Contracts Data Data Coordinating Center Data Quality Development Diabetes Mellitus Disease Eating Enrollment Environment Environmental Exposure Environmental Risk Factor Epidemiology Etiology Evaluation Family Fasting Feces Food Freezing Funding Future Genes Genetic Genetic Polymorphism Genetic Predisposition to Disease Genetic Risk Genetic Variation Genotype Goals Hair Human Hypersensitivity Insulin Insulin-Dependent Diabetes Mellitus Laboratories Measures Methods Microsatellite Repeats Minisatellite Repeats Monitor Monozygotic twins Mycotoxins Neonatal Screening Nested Case-Control Study Newborn Infant Outcome Study Oxidants Parents Pathogenesis Penetrance Performance Peripheral Blood Mononuclear Cell Pharyngeal structure Play Population Prediabetes syndrome Protocols documentation Publishing Recruitment Activity Research Design Research Ethics Committees Research Personnel Risk Role Sampling Screening procedure Specimen Staging Statistical Data Interpretation Sterility Study Subject Surveys Swab Telephone Testing Time Toxin Twin Studies Urine Vaccination Washington Work Youth cohort diabetes risk disorder risk endocrine pancreas development follow-up gene environment interaction high risk high risk infant non-diabetic population based prevent programs promoter prospective stressor time use virus culture

项目摘要

DESCRIPTION (provided by applicant): The Environmental Determinants of Diabetes in the Young (TEDDY), a multicenter prospective cohort study, was initiated in 2003 to identify environmental factors that trigger or protect against the development of islet autoimmunity and type 1 diabetes (T1D). A successful study outcome should allow better understanding of the etiology and pathogenesis of T1D and the development of new strategies to prevent, delay, or reverse the disease. Newborns are screened by HLA-DR.DQ genotyping to identify those at increased risk for T1D. Eligible children are followed four times per year until 4 years of age and twice a year thereafter until 15 years of age. The specific aims of this Clinical Center renewal application are to: 1. Complete this Center's contribution to the HLA-DR.DQ screening of 361,000 newborns and enrollment of 7,800 high-risk infants into intensive prospective follow-up to achieve the overall TEDDY goals. 2. Refine strategies to retain subjects enrolled in the follow-up and collect all planned biological specimens and epidemiological data according to the standard protocol including close monitoring of performance and sample/data quality. 3. Ascertain prospectively development of islet autoantibodies and clinical T1D in the study subjects. 4. Perform planned laboratory tests at appropriate times using a nested case-control study design to answer specific scientific questions and hypotheses pertinent to the TEDDY study goals. 5. Analyze and publish laboratory and epidemiological data in collaboration with the TEDDY Data Coordinating Center (funded by a separate contract). 6. Guide the ongoing TEDDY project by participation of the Clinical Center investigators and staff in work of the study Steering Committee and sub-committees.

描述（由申请人提供）：在2003年启动了一项多中心前瞻性队列研究的年轻人（Teddy）中糖尿病的环境决定因素，以确定触发或预防胰岛自身免疫性和1型糖尿病（T1D）的环境因素。成功的研究结果应使得对T1D的病因和发病机理以及预防，延迟或扭转疾病的新策略的发展。 HLA-DR.DQ基因分型筛选了新生儿，以识别患有T1D风险增加的人。符合条件的儿童每年四次，直到4岁，此后每年两次，直到15岁。该临床中心更新应用的具体目的是：1。完成该中心对HLA-DR.DQ筛查的贡献，对361,000名新生儿进行筛查，并将7,800名高风险婴儿入学到深度的前瞻性随访中，以实现整体Teddy目标。 2。根据标准方案，包括对后续行动的受试者的保留策略，并根据标准协议收集所有计划的生物学标本和流行病学数据，包括对性能和样本/数据质量的密切监视。 3。在研究对象中确定胰岛自身抗体和临床T1D的前瞻性开发。 4.使用嵌套的病例对照研究设计在适当时间进行计划的实验室测试，以回答与泰迪研究目标有关的特定科学问题和假设。 5。与泰迪数据协调中心合作分析和发布实验室和流行病学数据（由单独的合同资助）。 6。通过临床中心研究人员和工作人员参加研究指导委员会和小组委员会的工作，指导正在进行的泰迪项目。