Effects on Caffeine on Adolescent Behavior and Physiology

咖啡因对青少年行为和生理的影响

基本信息

批准号：
7905143
负责人：
Jennifer L Temple
金额：
$ 14.36万
依托单位：
STATE UNIVERSITY OF NEW YORK AT BUFFALO
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-28 至 2012-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7905143
关键词：
15 year old 4 year old Accounting Acute Adolescent Adolescent Behavior Adult Age American Americas Amphetamines Animal Model Animals Area Arousal Attention Award Behavior Behavioral Behavioral Mechanisms Beverages Blood Pressure Brain Burn injury Caffeine Calories Candy Carbonated Beverages Child Chronic Cocaine Coffee Consumption DSM-IV Data Dental caries Detection Development Diagnostic and Statistical Manual Dose Drug Addiction Feeding behaviors Flavoring Food Food Preferences Frequencies Fruit Funding Goals Grant Hand Health Heart Rate Housing Human Individual Industry Ingestion Intake Juice Knowledge Lead Link Manufacturer Name Marketing Measurement Measures Mediating Methods Milk Motor Activity Neurons Nicotine Obesity Overweight Pathway interactions Patient Self-Report Pharmaceutical Preparations Physiological Physiology Placebos Population Principal Investigator Property Reaction Time Relative (related person)Reporting Research Research Personnel Rewards Risk Route Sales Schools Self Administration Self-Administered Source Sucrose Taste Perception Testing Time Training Tremor United States National Institutes of Health Water Weight Weight maintenance regimen Youth addiction age group base behavioral pharmacology caffeine dependence career craving design drinking drug of abuse drug sensitivity food consumption meetings novel preference programs psychologic response soft drink sugar sweetened beverage vigilance young adult

项目摘要

Americans consume over 15 billion gallons of soda per year; the equivalent of >550 cans per individual. Caffeine use in adolescents has increased by 70% in the past 30 years. Within this age group, the most popular route of caffeine administration is soda. In addition to potential health risks from consuming caffeine, soda tends to contain high levels of sugar, which puts children at risk for dental caries and overweight. Although it is unclear if caffeine itself is addictive, a subset of adult and adolescent caffeine users meet the Diagnostic and Statistical Manual for Mental Disorders-IV criteria for drug dependence. In addition, caffeine usage increases sensitivity and potentiates addiction to cocaine, amphetamine, and nicotine. Because sugar is a known "natural reward" that activates similar neuronal pathways as drugs of abuse, we hypothesize that the long-term pairing of caffeine with sugar leads to enhanced sugar consumption, potentially mediated by increased reinforcing value of foods and beverages containing added sugar. The studies outlined here will test this hypothesis as well as determine whether adolescents develop physiological and/or psychological tolerance to the effects of caffeine. Children ages 12-17 years will be subdivided into quartiles based on their self-reported daily caffeine intake. This will allow us to assess whether there are different levels of habitual caffeine use lead to changes in physiological and behavioral responses to caffeine administration. In Specific Aim 1, a dose response study will be conducted by taking physiological (heart rate, blood pressure, and hand tremor) and psychological measurements in response to administration of placebo and three doses of caffeine. In addition, the effects of caffeine on consumption of foods and beverages containing added sugar and sensitivity to and liking of sucrose will also be assessed. Specific Aim 2 will measure how chronic and acute caffeine modulates taste preferences for novel drinks. Finally, Specific Aim 3 will assess the relative reinforcing value of caffeinated and non-caffeinated beverages. These studies investigate a novel set of questions concerning the physiological and behavioral consequences of caffeine ingestion among adolescents. In addition, these results will provide information on the potential link between caffeine use and the development of food preferences, in particular preference for foods and beverage with high levels of added sugar. Obtaining NIH funding and completing this set of studies will contribute to the Principal Investigator's career goals by providing training in the areas of human ingestive behavior, behavioral pharmacology, and addiction. These studies are a first step toward establishing an independent line of research that involves studying neuronal mechanisms that regulate ingestive behavior. In addition, this award will demonstrate the funding potential necessary to become an independent investigator and to compete for an RO1 grant.

美国人每年消耗超过150亿加仑的苏打水；每个人的等效含量> 550罐。在过去的30年中，青少年使用咖啡因的使用率增加了70％。在这个年龄段，最多咖啡因管理的流行途径是苏打水。除了消费潜在的健康风险咖啡因，苏打水倾向于含有高水平的糖，这使儿童有龋齿和超重。尽管尚不清楚咖啡因本身是否会上瘾，但成人和青少年咖啡因的子集用户符合精神障碍 - IV依赖标准的诊断和统计手册。在此外，咖啡因的使用增加了敏感性，并增强对可卡因，苯丙胺和尼古丁。因为糖是一种已知的“自然奖励”，它激活与药物相似的神经元途径滥用，我们假设咖啡因与糖的长期配对会导致糖的增强消费，可能通过增加的食物和饮料的增强价值来介导糖。这里概述的研究将检验这一假设，并确定青少年是否发展对咖啡因作用的生理和/或心理耐受性。 12-17岁的儿童将是根据他们自我报告的每日咖啡因摄入量，细分为四分位数。这将使我们能够评估习惯性咖啡因的使用是否不同导致生理和行为的变化对咖啡因给药的反应。在特定目标1中，将通过服用进行剂量反应研究生理（心率，血压和手震颤）和心理测量服用安慰剂和三剂咖啡因。此外，咖啡因对消费的影响还将评估含有添加糖的食物和饮料对蔗糖的敏感性和敏感性。特定目标2将测量慢性和急性咖啡因如何调节新型饮料的口味偏好。最后，特定的目标3将评估咖啡因和非咖啡因的相对增强价值饮料。这些研究研究了有关生理和行为的一组新的问题青少年摄入咖啡因的后果。此外，这些结果将提供有关咖啡因使用与食物偏好的发展之间的潜在联系，特别是偏爱食品和饮料含量高糖。获得NIH资金并完成这套研究将通过在人类领域提供培训来为主要研究者的职业目标做出贡献摄取行为，行为药理学和成瘾。这些研究是迈向的第一步建立独立的研究线，涉及研究调节的神经元机制摄取行为。此外，该奖项将证明成为成为一名的资金潜力独立调查员并争夺RO1赠款。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Influence of caffeine on the liking of novel-flavored soda in adolescents.

咖啡因对青少年新味汽水喜好的影响。

DOI：
10.1007/s00213-012-2684-2
发表时间：
2012
期刊：
Psychopharmacology
影响因子：
3.4
作者：
Temple,JenniferL;Ziegler,AmandaM;Graczyk,Adam;Bendlin,Ashley;O'Leary,Shannon;Schnittker,YaseminS
通讯作者：
Schnittker,YaseminS

Factors that influence the reinforcing value of foods and beverages.