The Environmental Determinants of Diabetes in Youth: Washington Clinical Center

青少年糖尿病的环境决定因素：华盛顿临床中心

基本信息

批准号：
8513065
负责人：
William A. Hagopian
金额：
$ 457.94万
依托单位：
PACIFIC NORTHWEST RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-03-01 至 2018-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8513065
关键词：
15 year old 4 year old Address Affect Age Ancillary Study Autoantibodies Autoimmune Diseases Autoimmunity Biological Biological Markers Birth Celiac Disease Child Child Development Clinical Cohort Studies Collaborations Colorado Communities Contracts Country DNA Data Data Coordinating Center Development Diabetes Mellitus Diagnosis Dietary Factors Disease Enrollment Environment Environmental Exposure Environmental Risk Factor Epidemiology Ethnic Origin Etiology Europe Event Feces Finland Florida Funding Gender Genes Genetic Genetic Polymorphism Genotype Germany Goals HLA-DR Antigens Infant Infection Infectious Agent Insulin Insulin-Dependent Diabetes Mellitus Laboratories Monitor National Institute of Diabetes and Digestive and Kidney Diseases Nested Case-Control Study Newborn Infant Outcome Study Participant Pathogenesis Performance Peripheral Blood Mononuclear Cell Plasma Prevention Protocols documentation Publishing RNA Research Design Research Personnel Resolution Resources Risk Risk Estimate Sampling Scientist Specimen Sweden Testing Time United States United States National Institutes of Health Washington Work Youth cohort design diabetes risk endocrine pancreas development follow-up gene environment interaction high risk improved infancy insight islet novel prevent prospective public health relevance repository time use

项目摘要

DESCRIPTION (provided by applicant): The Environmental Determinants of Diabetes in the Young (TEDDY) study was initiated in 2003 by six clinical centers in the United States and Europe, including ours, to identify infectious agents, dietary factors, or other environmental exposures that may trigger or protect against the development of islet autoimmunity and type 1 diabetes (T1D). Additional long-term scientific goals include assessment of potential gene-environment interactions affecting development of islet autoimmunity or T1D, gaining insight on mechanisms, and sharing collected specimens with broader scientific community for studies of T1D pathogenesis and prevention. A total of 424,788 newborns have been screened by HLA-DR, DQ genotyping to identify children at increased risk for T1D and 8677 are followed four times a year until 4 years of age and twice a year thereafter until age 15. Our Clinical Center has enrolled 1,379 TEDDY participants; of those 41 have developed persistent confirmed islet autoantibodies and 9 have been diagnosed with T1D, as of 6/30/2012. The specific aims of this renewal application for our multi-center, prospective cohort study are to: 1) Follow the TEDDY cohort of 8,677 high-risk children for development of islet autoimmunity and diabetes and celiac disease for 5 more years; 2) Collect all planned biological specimens and epidemiological data according to the standard TEDDY protocol including close monitoring of performance and of the quality of samples and data; 3) Perform planned laboratory tests at appropriate times using a nested case-control study design to answer specific scientific questions and hypotheses pertinent to the TEDDY study goals; 4) Analyze and publish laboratory and epidemiological data in collaboration with the TEDDY Data Coordinating Center (funded separately), and 5) Guide the ongoing TEDDY project by participation of the Clinical Center investigators and staff in work of the study Steering Committee and sub-committees. A successful study outcome should allow better understanding of the etiology and pathogenesis of islet autoimmunity and T1D and the development of new strategies to prevent, delay, or reverse the disease.

描述（由申请人提供）：年轻（泰迪）研究中糖尿病的环境决定因素是在2003年由美国和欧洲的六个临床中心（包括我们的）启动的，以识别传染性药物，饮食因素或其他可能会触发或保护胰岛自动免疫性和1型糖尿病的环境暴露。其他长期的科学目标包括评估影响胰岛自身免疫或T1D发展的潜在基因环境相互作用，对机制的洞察力，并与更广泛的科学界共享了收集的标本，以研究T1D发病机理和预防。 HLA-DR，DQ基因分型筛选了总共424,788名新生儿，以确定T1D风险增加和8677的儿童每年四次，直到4岁，此后每年两次，直到15岁。从6/30/2012开始，这41个已经开发了持续的确认胰岛自身抗体，其中9个已被诊断为T1D。该更新应用于我们的多中心，前瞻性队列研究的具体目的是：1）遵循8,677名高危儿童的泰迪同类，以发展胰岛自身免疫性，糖尿病和腹腔疾病5年； 2）根据标准泰迪协议收集所有计划的生物学标本和流行病学数据，包括对性能的密切监视以及样品和数据的质量； 3）使用嵌套的病例对照研究设计在适当的时间进行计划的实验室测试，以回答与泰迪研究目标有关的特定科学问题和假设； 4）与泰迪数据协调中心合作分析和发布实验室和流行病学数据（分别资助），5）指导临床中心研究人员和研究指导委员会工作人员和小组委员会工作的工作人员参与持续的泰迪项目。成功的研究结果应使胰岛自身免疫和T1D的病因学和发病机理以及预防，延迟或扭转疾病的新策略的发展。