Prenatal and Childhood Exposure to Fluoride and Neurodevelopment

产前和儿童期接触氟化物与神经发育

• 批准号: 8271682
• 负责人: Karen Eileen Peterson
• 金额: $ 58.76万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-06-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8271682
• 关键词: 14 year old; 15 year old; 2 year old; 4 year old; Achievement; Address; Age; Archives; Award; Biological Markers; Birth; Child; Childhood; Cognition; Cognitive; Cohort Studies; Data; Decision Making; Dental Hygiene; Dentifrices; Development; Diet; Dietary intake; Dose; Environmental Epidemiology; Epidemiologic Studies; Exposure to; Fasting; Fluorides; Food; Goals; Influentials; Intelligence; Investigation; Knowledge; Laboratories; Lead; Life; Life Style; Maternal Exposure; Measures; Methods; Mexico; Modification; Molecular; Mothers; National Institute of Environmental Health Sciences; National Research Council; Nature; Neurotoxins; Outcome; Paper; Pattern; Performance; Plasma; Policies; Population; Predisposition; Pregnancy; Publishing; Reporting; Research; Resources; Risk Assessment; Risk Factors; Sample Size; Sampling; Shapes; Sodium Chloride; Specimen; Structure of nail of toe; Testing; Time; Toxic Environmental Substances; Urine; Variant; cognitive function; cohort; cost; drinking water; early life exposure; evidence base; indexing; lead exposure; lead fluoride; mental development; neurobehavior; neurobehavioral; neurodevelopment; offspring; postnatal; prenatal; prenatal exposure; programs; response; salt intake; toxicant; urinary

DESCRIPTION (provided by applicant): In this new R01, we will capitalize on the unique resources of our Early Life Exposure in Mexico to ENvironmental Toxicants (ELEMENT) program, a molecular environmental epidemiology birth cohort study that won the 1999 NIEHS Progress and Achievement Award, to conduct a rigorous study of the potential impact of population-wide levels of exposure to fluoride on neurodevelopment. This effort addresses a 2007 US National Research Council report which concluded that more research is needed to address the possibility that population-wide levels of fluoride exposure may pose a significant threat to neurobehavior. The exceptional data and resources of ELEMENT has allowed our team to publish over 40 papers related to the impact of prenatal and childhood exposure to lead and other toxicants on neurobehavioral and physical development. Using levels of fluoride measured in our archived urine, fasting plasma and toenail specimens, validated measures widely recognized as being the best available biomarkers of fluoride exposure, we propose to study the impact of prenatal and childhood fluoride exposures on widely used and validated measures of neurobehavior at 2 to 14 years of age utilizing 3 of the 4 cohorts of ELEMENT. Our pilot research on archived urine and plasma samples from 40 randomly chosen mother-offspring pairs using rigorous and cross-validated laboratory methods indicates that our ELEMENT subjects have a distribution of fluoride levels that will enable us to pursue our specific aims. Further, our pilot data shows evidence of an inverse relationship between prenatal biomarkers of fluoride exposure and general cognitive function at 2 years (Bayley Scales of Mental Development), 4 years (McCarthy Scales of Children's Abilities) and 7-14 years (Wechsler Abbreviated Scales of Intelligence). Our overall goals will be to conduct a full investigation to () address hypotheses on the potential impact of pre- and postnatal exposures to fluoride on measures of overall neurobehavioral function; (B) explore the potential impacts of fluoride exposure on specific domains of neurobehavioral function, the shape of the dose-response relationships, differential susceptibility in relation to time windows of exposure (prenatal v. childhood), and, using archived data, potential interactions with lead exposure, another widely- distributed neurotoxicant; and (C) conduct a study of offspring to examine the drinking water, dietary, dentifrice, lifestyle, and other determinants of current urinary and toenail fluoride leves. Given the power of our archived resources and sample sizes, we will be able to accomplish this research at a small fraction of the cost and time required of a new study. PUBLIC HEALTH RELEVANCE: This research will directly address the issue as to whether population-wide levels of prenatal and/or childhood fluoride exposure is a significant risk factor for some forms of adverse neurobehavioral performance. Given the widespread nature of fluoride use and exposure and the lack of rigorous epidemiologic research on this topic of the current base of evidence, this research promises to make a major contribution to fluoride risk assessment and policy decision-making.

DESCRIPTION (provided by applicant): In this new R01, we will capitalize on the unique resources of our Early Life Exposure in Mexico to ENvironmental Toxicants (ELEMENT) program, a molecular environmental epidemiology birth cohort study that won the 1999 NIEHS Progress and Achievement Award, to conduct a rigorous study of the potential impact of population-wide levels of exposure to fluoride on neurodevelopment.这项工作涉及2007年美国国家研究委员会的报告，得出的结论是，需要更多的研究来解决范围内氟化物暴露水平的可能性，可能会对神经行为构成重大威胁。元素的非凡数据和资源使我们的团队能够发表与产前和儿童期暴露于铅和其他有毒物质对神经行为和身体发展的影响有关的40多篇论文。我们使用在我们的存档尿液，禁食等离子体和脚趾甲样本中测得的氟化物水平，经过验证的措施被广泛认为是氟化物暴露的最佳可用生物标志物，我们建议研究产前和儿童氟化物对广泛使用和验证的神经bo的措施在2至14岁时的神经虫的衡量标准的影响。我们对使用严格和跨验证的实验室方法从40对随机选择的母亲源对尿液和血浆样品进行的试点研究表明，我们的元素受试者具有氟化物水平的分布，这将使我们能够追求我们的特定目标。此外，我们的飞行员数据显示了2年（贝利心理发展范围），4年（儿童能力的麦卡锡量表）和7-14岁的氟化物暴露产前生物标志物与一般认知功能之间存在反比关系的证据。我们的总体目标是进行全面调查，以解决（）关于出生前和产后暴露对氟化物对整体神经行为功能措施的潜在影响的假设； （b）探索氟化物暴露对神经行为功能特定领域的潜在影响，剂量反应关系的形状，与时间窗口有关的差异敏感性（产前诉儿童期）以及使用存档的数据，使用铅的相互作用，潜在的与铅暴露的相互作用（c）对后代进行研究，以检查饮用水，饮食，牙齿，生活方式以及当前尿液和脚趾甲氟化物leves的其他决定因素。鉴于我们存档的资源和样本量的力量，我们将能够以新研究所需的一小部分成本和时间来完成这项研究。 公共卫生相关性：这项研究将直接解决有关范围范围内的产前和/或儿童氟化物暴露水平的问题，是某些形式的不良神经行为表现的重要危险因素。鉴于氟化物使用和暴露的广泛性质以及缺乏对当前证据基础的严格流行病学研究，因此这项研究有望为氟化物风险评估和政策决策做出重大贡献。