NEURAL BASES OF EMOTION REGULATION AND DYSREGULATION IN ADOLESCENCE

青春期情绪调节和失调的神经基础

• 批准号: 8076863
• 负责人: Richard J Davidson
• 金额: $ 28.1万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8076863
• 关键词: 14 year old; 15 year old; 16 year old; 2 year old; Address; Adolescence; Adolescent; Affect; Affective; Age; Amygdaloid structure; Anger; Anxiety; Behavioral; Biological; Brain; Data; Development; Diffusion Magnetic Resonance Imaging; Disease; Dizygotic Twins; Emotional; Exhibits; Eye; Face; Facial Expression; Fright; Functional Magnetic Resonance Imaging; Hydrocortisone; Image; Individual; Individual Differences; Inferior frontal gyrus; Instruction; Life; Magnetic Resonance Imaging; Measures; Mood Disorders; Participant; Pattern; Peripheral; Phase; Physiological; Prefrontal Cortex; Process; Risk; Role; Sampling; Scanning; Short-Term Memory; Structure; Symptoms; Testing; Twin Multiple Birth; base; cognitive control; cohort; comparison group; design; early adolescence; emotion regulation; falls; follow-up; indexing; meetings; member; novel; relating to nervous system; response; showing emotion; social

This project will examine the neural bases of emotion regulation and dysregulation in samples of adolescents selected on the basis of their risk status for internalizing disorder. Adolescent is a period during which risk for anxiety and mood disorders increases substantially and little is known about the brain mechanisms responsible for vulnerability to these disorders. We will take advantage of extensive data collected within two longitudinal cohorts that will be a central feature of this Center. From these cohorts, three samples will be tested. One sample consists of 85 individuals from Project 2 who underwent fMRI scanning using virtually the identical tasks when they were 14 years of age. A second sample, also derived from Project 2 (Essex), will include participants who will be selected to vary in levels of basal cortisol early in life (age 4.5 years) and later in early adolescence. In another cohort derived from Project 3 (Goldsmith) monozygotic and dizygotic twin pairs will be selected in which one member of the pair has high levels of internalizing symptoms. Both concordant and discordant pairs will be selected in this manner. All participants will undergo a scanning session during which functional MRI will be obtained while participants engage in two tasks. One task will assess the neural correlates of both voluntary and automatic emotion regulation while the other task will be a face go-no-go task that assesses sensitivity to different facial expressions of emotion and inhibitory control in the face of emotional distracters. During scanning, electrodermal and pupillary measures will be obtained, in addition to eye tracking. In addition, participants will be administered an automated version of a task designed to assess working memory capacity (O-span) to ascertain the relation between individual differences in working memory capacity and emotion regulation. We will test the hypothesis that adolescents selected to be vulnerability to internalizing disorders (either because of cortisol profiles or symptoms of anxiety) will exhibit evidence of the poor emotion regulation expressed as high levels of amygdala activation and low levels of activation in ventromedial prefrontal cortex during instructions to down-regulate negative affect. A similar pattern is expected during the task phase designed to assess automatic emotion regulation. The face go-no-go task will allow us to test the hypothesis that adolescents at increased risk for internalizing disorders will show increased sensitivity to fear and angry faces and show a more conservative response bias (inhibiting their response to faces other than the target); moreover these individuals are predicted to show increased activation in the right inferior frontal gyrus, a region in which we have previously found to correlated with social anxiety. The findings from this project will provide novel new evidence on the neural bases of emotion regulation and dysregulation in adolescence and will showcase the role of these processes in vulnerability to anxiety and mood disorders.

该项目将研究青少年样本中情绪调节和失调的神经基础 根据他们的内化障碍风险状况进行选择。青春期是一个容易面临风险的时期 焦虑和情绪障碍大幅增加，但人们对大脑机制知之甚少 造成这些疾病的脆弱性。我们将利用在内部收集的广泛数据 两个纵向队列将成为该中心的核心特征。从这些队列中，三个样本将 被测试。一个样本由来自项目 2 的 85 名个体组成，他们使用 他们 14 岁时几乎完成了相同的任务。第二个示例，也来自项目 2 （埃塞克斯），将包括被选中的参与者，他们在生命早期（4.5 岁）的基础皮质醇水平有所不同 年）以及后来的青春期早期。在来自项目 3（Goldsmith）的另一个队列中，单合子和 将选择异卵双胞胎，其中一对成员具有高水平的内化 症状。一致和不一致的对都将以这种方式被选择。所有参与者将 接受扫描过程，在此期间将获得功能性核磁共振成像，同时参与者参与两个 任务。一项任务将评估自愿和自动情绪调节的神经相关性，同时 另一项任务是面部 go-no-go 任务，评估对不同面部表情情绪的敏感性 以及面对情绪干扰时的抑制控制。扫描期间，皮电和瞳孔 除了眼动追踪之外，还将获得其他措施。此外，参与者将接受 旨在评估工作记忆容量（O-span）以确定关系的任务的自动化版本 工作记忆能力和情绪调节的个体差异。我们将测试 假设青少年选择容易遭受内化障碍（要么是因为皮质醇 焦虑的概况或症状）将表现出情绪调节不良的证据，表现为高 指令期间杏仁核激活水平和腹内侧前额叶皮质低水平激活 下调负面影响。在旨在评估的任务阶段预计会出现类似的模式 自动情绪调节。面对“走-不走”任务将使我们能够检验以下假设：青少年在 内化障碍的风险增加会表现出对恐惧和愤怒面孔的敏感性增加，并表现出 更保守的反应偏差（抑制他们对目标以外的面孔的反应）；而且这些 预计个体的右额下回会表现出更多的激活，我们在该区域中 此前已发现与社交焦虑相关。该项目的研究结果将提供新颖的 关于青春期情绪调节和失调的神经基础的证据，并将展示 这些过程在易患焦虑和情绪障碍方面的作用。