NEURAL BASES OF EMOTION REGULATION AND DYSREGULATION IN ADOLESCENCE

青春期情绪调节和失调的神经基础

• 批准号: 8076863
• 负责人: Richard J Davidson
• 金额: $ 28.1万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8076863
• 关键词: 14 year old; 15 year old; 16 year old; 2 year old; Address; Adolescence; Adolescent; Affect; Affective; Age; Amygdaloid structure; Anger; Anxiety; Behavioral; Biological; Brain; Data; Development; Diffusion Magnetic Resonance Imaging; Disease; Dizygotic Twins; Emotional; Exhibits; Eye; Face; Facial Expression; Fright; Functional Magnetic Resonance Imaging; Hydrocortisone; Image; Individual; Individual Differences; Inferior frontal gyrus; Instruction; Life; Magnetic Resonance Imaging; Measures; Mood Disorders; Participant; Pattern; Peripheral; Phase; Physiological; Prefrontal Cortex; Process; Risk; Role; Sampling; Scanning; Short-Term Memory; Structure; Symptoms; Testing; Twin Multiple Birth; base; cognitive control; cohort; comparison group; design; early adolescence; emotion regulation; falls; follow-up; indexing; meetings; member; novel; relating to nervous system; response; showing emotion; social

This project will examine the neural bases of emotion regulation and dysregulation in samples of adolescents selected on the basis of their risk status for internalizing disorder. Adolescent is a period during which risk for anxiety and mood disorders increases substantially and little is known about the brain mechanisms responsible for vulnerability to these disorders. We will take advantage of extensive data collected within two longitudinal cohorts that will be a central feature of this Center. From these cohorts, three samples will be tested. One sample consists of 85 individuals from Project 2 who underwent fMRI scanning using virtually the identical tasks when they were 14 years of age. A second sample, also derived from Project 2 (Essex), will include participants who will be selected to vary in levels of basal cortisol early in life (age 4.5 years) and later in early adolescence. In another cohort derived from Project 3 (Goldsmith) monozygotic and dizygotic twin pairs will be selected in which one member of the pair has high levels of internalizing symptoms. Both concordant and discordant pairs will be selected in this manner. All participants will undergo a scanning session during which functional MRI will be obtained while participants engage in two tasks. One task will assess the neural correlates of both voluntary and automatic emotion regulation while the other task will be a face go-no-go task that assesses sensitivity to different facial expressions of emotion and inhibitory control in the face of emotional distracters. During scanning, electrodermal and pupillary measures will be obtained, in addition to eye tracking. In addition, participants will be administered an automated version of a task designed to assess working memory capacity (O-span) to ascertain the relation between individual differences in working memory capacity and emotion regulation. We will test the hypothesis that adolescents selected to be vulnerability to internalizing disorders (either because of cortisol profiles or symptoms of anxiety) will exhibit evidence of the poor emotion regulation expressed as high levels of amygdala activation and low levels of activation in ventromedial prefrontal cortex during instructions to down-regulate negative affect. A similar pattern is expected during the task phase designed to assess automatic emotion regulation. The face go-no-go task will allow us to test the hypothesis that adolescents at increased risk for internalizing disorders will show increased sensitivity to fear and angry faces and show a more conservative response bias (inhibiting their response to faces other than the target); moreover these individuals are predicted to show increased activation in the right inferior frontal gyrus, a region in which we have previously found to correlated with social anxiety. The findings from this project will provide novel new evidence on the neural bases of emotion regulation and dysregulation in adolescence and will showcase the role of these processes in vulnerability to anxiety and mood disorders.

该项目将检查青少年样本中情绪调节和失调的神经基础 根据其内部化障碍的风险状态选择。青少年是风险的时期 焦虑和情绪障碍大大增加，对大脑机制知之甚少 负责这些疾病的脆弱性。我们将利用收集的大量数据 两个纵向人群将是该中心的中心特征。从这些队列中，将三个样本 进行测试。一个样本由项目2的85个人组成，他们使用fMRI扫描使用 实际上，当他们14岁时的任务几乎相同。第二个样本，也来自项目2 （Essex）将包括将被选为生命早期基底皮质醇水平的参与者（4.5岁 几年）和青春期初期。在另一个来自项目3（Goldsmith）单卵的队列中 将选择双叶双胞胎对，其中一对成员具有很高的内在化水平 症状。一致和不一致的对将以这种方式选择。所有参与者都会 在参与者参与两个时进行扫描会议，在此期间将获得功能性MRI 任务。一项任务将评估自愿和自动情绪调节的神经相关性 另一个任务将是一项面对不做的任务，可以评估对情感的不同面部表情的敏感性 面对情绪干扰者，抑制性控制。在扫描期间，电肌和瞳孔 除了眼睛跟踪外，还将获得措施。此外，将管理参与者 旨在评估工作记忆能力（O-SPAN）的任务的自动化版本以确定关系 在工作记忆能力和情绪调节中的个体差异之间。我们将测试 假设青少年被选为内在疾病的脆弱性（要么是由于皮质醇 焦虑的特征或症状）将表现出表达不良的情绪法规的证据 杏仁核激活水平和腹侧前额叶皮层的激活水平低。 下调负面影响。预计在旨在评估的任务阶段将有类似的模式 自动情绪调节。面对工作任务将使我们能够测试青少年在 增加内在疾病的风险将表现出对恐惧和愤怒面孔的敏感性，并显示 更保守的响应偏见（抑制它们对目标以外的面孔的反应）；而且这些 预计个体在右下额回中表现出增加的激活，这是我们的一个地区 以前发现与社交焦虑相关。该项目的发现将提供新颖的新 关于情绪调节和青春期失调的神经基础的证据，将展示 这些过程在焦虑和情绪障碍的脆弱性中的作用。