E3Gen: Multigenerational Effects of Toxicant Exposures on Life Course Health and Neurocognitive Outcomes in the ELEMENT Birth Cohorts

E3Gen：有毒物质暴露对 ELEMENT 出生队列生命周期健康和神经认知结果的多代影响

• 批准号: 10207628
• 负责人: Karen Eileen Peterson
• 金额: $ 32.23万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-30 至 2022-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10207628
• 关键词: Adolescence; Adolescent; Age; Animal Model; Attention; Barker Hypothesis; Birth; Chemical Exposure; Child; Childhood; Cohort Studies; Collaborations; Communication; Communities; Conceptions; Data; Data Analytics; Databases; Dental caries; Development; Elderly; Endocrine Disruptors; Environmental Exposure; Environmental Health; Environmental Impact; Epigenetic Process; Exposure to; Funding; Future; Generations; Germ Lines; Goals; Growth; Health; Human; Image; Individual; Infant; Institutes; Institution; Life; Life Cycle Stages; Life course epidemiology; Long-Term Effects; Maintenance; Mediating; Mediation; Menopause; Metabolic; Metabolic syndrome; Metals; Methods; Mexico; Michigan; Modeling; Monoclonal Antibody R24; Mothers; National Institute of Environmental Health Sciences; Neurocognitive; Oral health; Outcome; Parents; Participant; Perimenopause; Perinatal; Play; Pregnancy; Process; Research; Research Infrastructure; Research Personnel; Resource Sharing; Risk; Role; Secure; Techniques; Testing; Toxic Environmental Substances; Toxicant exposure; Universities; Weight Gain; Woman; Work; aged; base; biobank; cohort; data harmonization; data integration; data management; data sharing; design; developmental plasticity; disorder risk; early life exposure; epigenome; epigenomics; fluorosis; follow-up; grandparent; improved; in utero; lipidomics; metabolomics; microbiome; middle age; multidimensional data; next generation; novel; nutrition; oral microbiome; perinatal period; postnatal; prevent; puberty transition; recruit; search engine; senescence; toxicant; young adult

E3Gen: Multigenerational effects of toxicant exposures on life course health and neurocognitive outcomes in the ELEMENT birth cohorts SUMMARY The impact of environmental toxicants on health and disease risk during sensitive developmental periods has been recognized for nearly 20 years, as highlighted by the developmental origins of adult disease hypothesis and life course epidemiology. Yet, the potential to understand novel mechanisms implicit in these frameworks has not been fully realized. Few environmental cohorts have followed mother-child dyads beyond adolescence, precluding the ability to understand long-term impacts of toxicant exposures in young adulthood and perimenopause—both dynamic life stages characterized by increased risk of metabolic syndrome and potential changes in neurocognitive processes. The E3Gen project, based on our highly successful, 22-year research collaboration with the Instituto Nacional de Salud Pública de Mexico (INSP), comprises three birth cohorts of women originally recruited from 1994- 2004, their children now aged 12-22 years, and the next generation of grandchildren currently being born. This R24 application leverages the research infrastructure of our ongoing studies in the Early Life Exposure in Mexico to ENvironmental Toxicants (ELEMENT) cohorts and of three NIEHS-funded centers at the University of Michigan, creating an unparalleled opportunity launch new research that maximizes use of the existing biorepository and rich database of repeated toxicant exposures and metabolic and neurocognitive outcomes and that promotes accelerated data and resource sharing with the larger environmental health sciences community. Specific Aims are to: 1) Maintain and enhance the scientific integrity of the E3Gen multigenerational cohort and implement strategies to encourage participation and prevent loss to follow up among 850 mothers aged 38-50 years, their children aged 12-22 years, while also recruiting 90 grandchildren currently and projected to be born over the next five years; 2) Prepare for future scientific studies considering the roles of epigenetics, oral health and oral microbiome in mediating the impact of endocrine disrupting chemicals (EDCs) and metals on metabolic and neurocognitive outcomes across three generations of ELEMENT participants; 3) Develop and test novel data management techniques to improve and enrich data integration and harmonization, data sharing, and cross-project data communication.

E3GEN：毒物暴露对生命课程健康和神经认知的多代作用 元素出生队列中的结果 概括 敏感发展期间环境有毒物质对健康和疾病风险的影响 成人的发展起源强调了近20年的时期已有近20年 疾病假设和生命过程流行病学。但是，了解新型机制的潜力 这些框架中的隐含尚未完全实现。很少有环境人群随之而来 母子超出青少年的二元组，排除了理解长期影响的能力 在成年和围世的年轻人中暴露的毒物暴露 - 以动态生活阶段为特征 代谢综合征的风险增加和神经认知过程中的潜在变化。 E3Gen 基于我们与Instituto Nacional de的非常成功的22年研究合作的项目 SaludPúblicade Mexico（INSP）包括最初从1994年招募的三名妇女。 2004年，他们的孩子现在年龄12-22岁，下一代孙子正在 出生。此R24应用利用了我们早期正在进行的研究的研究基础设施 在墨西哥接触环境有毒物质（元素）同类和三个NIEHS资助 密歇根大学的中心，创造了无与伦比的机会启动新的研究 最大化现有的生物座席和丰富的毒物暴露数据库和丰富的数据库 代谢和神经认知结果，这促进了加速的数据和资源共享 更大的环境健康科学社区。具体目的是：1）维护和增强 E3Gen多代人群的科学完整性并实施策略以鼓励 参与并防止在38-50岁的850位母亲中损失，他们的孩子年龄 12 - 22年，同时还招募了90个孙子，预计将在接下来的五个 年; 2）为未来的科学研究做准备，考虑表观遗传学，口腔健康和口腔的作用 微生物组介导内分泌破坏化学物质（EDC）和金属对代谢的影响 以及三代元素参与者的神经认知结果； 3） 开发和测试 新的数据管理技术以改善和丰富数据集成和协调，数据 共享和跨项目通信。