EFFECT OF CHROMIUM ON PROGRESSION OF INSULIN RESISTANCE

铬对胰岛素抵抗进展的影响

• 批准号: 7959019
• 负责人: PETER J HAVEL
• 金额: $ 10.67万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7959019
• 关键词: Attenuated; Bioavailable; Biological Availability; Body fat; California; Chromium; Chromium Picolinate; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Development; Diet; Dyslipidemias; Ensure; Funding; Grant; High Density Lipoproteins; Human; Hypertriglyceridemia; Inflammatory; Institution; Insulin; Insulin Resistance; Intake; Link; Lipids; Long-Term Effects; Macaca mulatta; Metabolic; Metabolic Diseases; Metabolic syndrome; Modeling; Muscle; Obesity; Plasma; Primates; Research; Research Personnel; Resources; Source; Supplementation; Syndrome; Tissues; Triglycerides; United States National Institutes of Health; Weight; cardiovascular risk factor; design; feeding; improved; insulin sensitivity; nicotinate; nonhuman primate; oxidation; prevent; respiratory; sugar; sweetened beverage

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this project is to determine the effect of long term supplementation with Chromium in the progression of Metabolic Syndrome in obese rhesus monkeys fed sugar sweetened beverages. Chromium supplementation has been demonstrated to improve insulin sensitivity in some, but not all, studies conducted in insulin-resistant subjects. Chromium has also been suggested to have effects to improve plasma lipid profiles. This study examines the long-term (1 year) effects of chromium supplementation to prevent or attenuate the progression of insulin resistance and dylipidemia in a nonhuman primate model of the Metabolic (insulin resistance) Syndrome. The development of insulin resistance in obese rhesus monkeys shares similar features with the progression of metabolic disease in humans. We have previously demonstrated that providing obese rhesus monkeys with a sugar-sweetened beverage daily in combination with ad libitum access to their normal diet for 1 year results in modest weight and body fat gain accompanied by a rapid progression of insulin resistance and dyslipidemia (elevated triglyceride and reduced HDL levels). The use of this model in which rigorous control and compliance with diet and chromium intake can be ensured will allow us to determine the effects of long-term chromium supplementation in the progression of the metabolic syndrome. In addition, we will assess the effects of chromium on a number of lipid and inflammatory parameters associated with insulin resistance and cardiovascular risk. We will also determine the effects of chromium on two parameters closely linked to muscle insulin action; muscle triglyceride content and whole body substrate oxidation (respiratory quotient). Although chromium picolinate is the most widely used form of chromium supplement, some studies suggest that the nicotinate form of chromium is more bioavailable and therefore more effective. Therefore, we will compare the bioavailability (tissue chromium status) and the efficacy of chromium picolinate and chromium nicotinate in the amelioration of diet-induced insulin resistance and dyslipidemia. The results of these studies will provide valuable information for the design and implementation of new clinical studies examining the effects of chromium supplements in the management of metabolic syndrome in humans.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该项目的目的是确定肥胖的恒河猴在代谢综合征进展中长期补充铬的饮料饮料中的代谢综合征的影响。已经证明，补充铬可以提高某些但不是全部在耐胰岛素受试者中进行的研究。还建议铬具有改善血浆脂质谱的作用。这项研究研究了补充铬的长期（1年）影响，以预防或减轻代谢（胰岛素抵抗）综合征的非人类灵长类动物模型中胰岛素抵抗和二脂血症的进展。肥胖恒河猴中胰岛素抵抗的发展与人类代谢疾病的发展具有相似的特征。我们以前已经证明，每天提供肥胖的恒河猴每天提供糖甜饮料，并随意获得其正常饮食的饮食，从而导致体重适度和体内脂肪的增加，并伴随着胰岛素抵抗和流利性血症的快速发展（trigicaide升高，甘油三酸酯升高，HDL降低了HDL水平）。可以确保严格控制和遵守饮食和铬摄入量的模型的使用将使我们能够确定补充铬在代谢综合征进展中的影响。此外，我们将评估铬对与胰岛素抵抗和心血管风险相关的许多脂质和炎症参数的影响。我们还将确定铬对与肌肉胰岛素作用密切相关的两个参数的影响；肌肉甘油三酸酯含量和全身底物氧化（呼吸商）。尽管Picolinate铬是铬补充剂最广泛使用的形式，但一些研究表明，铬酸形式的铬形式更具生物利用，因此更有效。因此，我们将比较生物利用度（组织铬状态）以及粘酸铬和烟酸铬酸铬酸铬在饮食诱导的胰岛素抵抗和血脂异常的疗效中的疗效。这些研究的结果将为设计和实施新的临床研究提供有价值的信息，以研究铬补充剂对人类代谢综合征管理的影响。