Adverse metabolic effects of dietary sugar _ Ad libitum vs energy-balanced diets

膳食糖对代谢的不良影响_随意饮食与能量平衡饮食

• 批准号: 8613141
• 负责人: PETER J HAVEL
• 金额: $ 74.34万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-27 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8613141
• 关键词: Adipose tissue; Adult; Adverse effects; Apolipoproteins B; Aspartame; Beverages; Blinded; Body Weight; Calories; Carbohydrates; Cardiovascular Diseases; Cholesterol; Consumption; Control Groups; Data; Deposition; Development; Diabetes Mellitus; Diet; Dietary Sugars; Energy Intake; Exhibits; Fasting; Fatty acid glycerol esters; Food; Fructose; Glucose; Guidelines; Health Policy; Hepatic; Intake; Intervention; Intervention Studies; Investigation; Kinetics; Lead; Lipids; Lipoproteins; Liver; Low-Density Lipoproteins; Macronutrients Nutrition; Measures; Mediating; Metabolic; Metabolic Diseases; Metabolism; Milk; Muscle; Plasma; Procedures; Process; Production; Proteins; Public Health; Randomized; Reporting; Research Personnel; Risk; Risk Factors; Sucrose; Testing; Very low density lipoprotein; Visceral; Weight Gain; Woman; blood lipid; carbohydrate metabolism; dietary control; energy balance; glucose tolerance; insulin sensitivity; lipid biosynthesis; lipid metabolism; lipoprotein lipase; men; oxidation; prevent; public health relevance; sugar; sweetened beverage

9. Project Summary: Recent studies have demonstrated that consuming high fructose corn syrup (HFCS)- or sucrose-sweetened beverages increased lipid/lipoprotein risk factors for CVD in healthy adults compared with iso-caloric amounts of glucose or low-fat milk. The longest of these studies, which utilized a 6-month intervention, also showed increased liver and muscle TG and increased visceral adipose deposition. Neither of these studies found differences in weight gain between subjects consuming HFCS/sucrose beverages compared with control beverages. These results suggest that it is not just excess calories and weight gain that mediate the effects of dietary sugar/fructose on the development of metabolic disease; rather, dietary sugar per se is also a contributor. However, it is not known whether consumption of excessive amounts of sugar can increase risk factors for metabolic disease in the absence of positive energy balance and weight gain, nor whether the adverse effects of sugar consumption are exacerbated by weight gain. This study will test the overall hypotheses that consumption of HFCS-sweetened beverages increases risk factors for metabolic disease even when consumed with an energy-balanced diet that prevents weight gain, and that risk factors are increased to a greater extent when HFCS-sweetened beverages are consumed in a setting of positive energy balance that results in weight gain. We will also test the hypothesis, that under blinded, controlled, dietary conditions, consumption of HFCS-sweetened beverages will increase energy intake and body weight gain more than consumption of aspartame-sweetened beverages. We will measure risk factors and processes associated with metabolic disease in 3 groups of young, healthy adults who will consume 1) 25% of energy requirement as HFCS-sweetened beverages with an energy-balanced diet; 2) 25% of energy requirement as HFCS- sweetened beverages with an ad libitum diet; or 3) aspartame-sweetened beverages with an ad libitum diet for 8 weeks. All diets, formulated to achieve a comparable macronutrient intake (55% energy as carbohydrate, 35% fat, 15% protein) among all 3 experimental groups, will be provided to the subjects throughout the entire study. We hypothesize that consumption of HFCS-sweetened beverages with the energy-balanced diet will result in adverse metabolic effects, despite the absence of weight gain. Consumption of HFCS-sweetened beverages with the ad libitum diet will result in increased energy intake and body weight gain compared with aspartame-sweetened beverages, and will also result in adverse metabolic effects that are more marked than with consumption of HFCS-sweetened beverages with the energy-balanced diet. These results will demonstrate that consumption of HFCS-sweetened beverages increases risk for metabolic disease both directly, via the adverse effects of fructose on lipid and carbohydrate metabolism, and indirectly, via the effects of HFCS-sweetened beverages to promote excess energy intake and body weight gain. These findings will have the potential to influence dietary guidelines and public health policy.

9。项目摘要： 最近的研究表明，食用高果糖玉米糖浆（HFC）或蔗糖味 与ISO-Caloric量相比 葡萄糖或低脂牛奶。这些研究中最长的研究也显示了6个月的干预措施 肝脏和肌肉TG增加并增加内脏脂肪沉积。这些研究都没有发现 与对照相比 饮料。这些结果表明，介导 饮食糖/果糖关于代谢疾病的发展；相反，饮食糖本身也是 贡献者。但是，尚不知道消耗过量的糖是否会增加风险 在没有正能量平衡和体重增加的情况下代谢疾病的因素 糖消耗的不利影响会因体重增加而加剧。这项研究将测试总体 假设消费HFCS饮料会增加代谢疾病的危险因素 当用能量平衡的饮食消费时，可以防止体重增加，而风险因素则会增加到 在HFCS-散发饮料的情况下更大程度上 导致体重增加。我们还将检验以下假设，即在盲，受控的，饮食条件下， HFCS味的饮料的消费将增加能量摄入量，体重增加大于 消费阿斯巴甜饮料。我们将衡量与之相关的风险因素和过程 3组年轻，健康的成年人的代谢疾病，他们将消耗1）25％的能源需求 HFCS饮料的饮料，饮食； 2）25％的能源需求为HFCS- 随意饮食的甜饮料；或3）搭配饮食的阿斯巴甜饮料 8周。所有饮食均旨在获得可比的大量营养素摄入量（碳水化合物的能量为55％， 在所有3个实验组中，35％脂肪，15％蛋白质）将向整个受试者提供 学习。我们假设使用能量平衡饮食的HFCS饮料消费将 尽管没有体重增加，但仍会导致不良代谢作用。 hfcs-sweeted的消费 随意饮食的饮料将导致能量摄入量增加，体重增加 阿斯巴甜饮料饮料，也将导致不良代谢作用，这些作用比 随着能量均衡饮食的饮用饮料，饮用饮料。这些结果将会 证明HFCS甜饮料的消费会增加代谢性疾病的风险 直接通过果糖对脂质和碳水化合物代谢的不利影响，并间接地通过影响 HFCS味的饮料，以促进过量的能量摄入和体重增加。这些发现会 有可能影响饮食指南和公共卫生政策。