Administrative Core

行政核心

• 批准号: 10683317
• 负责人: Hemali Phatnani
• 金额: $ 79.41万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10683317
• 关键词: Adherence; Adult; Aging; Agreement; Annual Reports; Atlases; Biological; Biological Assay; Biological Markers; Blood; Brain; Cell Aging; Cells; Cerebrospinal Fluid; Collaborations; Common Data Element; Communication; Communities; Consent; Data; Data Analyses; Data Coordinating Center; Data Set; Decision Making; Disease; Documentation; Ectoderm; Ensure; Environment; Ethics; Evaluation; Evaluation Reports; Feedback; Fostering; Genome; Goals; Health; Heterogeneity; Human; Infrastructure; Knowledge; Laboratories; Leadership; Longevity; Management Information Systems; Maps; Metadata; Molecular; Monitor; New York; Output; Policies; Progress Reports; Protocols documentation; Research; Resolution; Resource Sharing; Resources; Role; Sampling; Site; Skin; Spinal Cord; Standardization; Structure; System; Tissue Procurements; Tissues; United States National Institutes of Health; Universities; Work; data sharing; implementation facilitation; innovation; meetings; multi-scale atlas; multidisciplinary; multimodality; novel; organizational structure; programs; senescence; success; synergism; tissue mapping

ADMINISTRATIVE CORE (ADM): PROJECT SUMMARY The Administrative Core (ADM) is a necessary component of the Columbia University Senescence Tissue Mapping (CUSTMAP) Center; it will provide research and logistical oversight and facilitate communication amongst all Center Cores as well as with the SenNet Consortium Organization and Data Coordination Center (CODCC), the SenNet consortium at large, and the NIH. The ADM, composed of a Director, all Center PIs (MPIs), an Executive Committee (all Core leadership), and support staff (Program Manager and Systems Analyst), will oversee and coordinate the direction of three Cores (a Biospecimen Core (BIO), a Biological Analysis Core (BAC), and a Data Analysis Core (DAC)). These Cores will contribute to the study of senescence in three primary tissue types, i.e., skin, brain, and spinal cord, across the adult lifespan. The ADM will have three main functions in support of the CUSTMAP Center and ultimately the SenNet consortium initiative. The first is Leadership, highlighted in Aim 1: Provide scientific leadership and governance structure to ensure integration and function of the CUSTMAP Center components and activities. CUSTMAP Center activities will span multiple sites (CUIMC-All Cores, Edinburgh University-BIO, New York Genome Center-BAC, and New York University- DAC) and therefore will require a central governing and organizing structure. The ADM will be the hub for decision making, all Center documentation, and adherence to ethical policies. Importantly, the ADM will ensure the CUSTMAP Center research is compliant with agreed upon standards and a resource sharing plan, formally set by the Center and with the NIH. The second role is Center Coordination, highlighted in Aim 2: Facilitate internal communication and promote synergy within the CUSTMAP Center. The ADM will provide coordination across all CUSTMAP Center Cores. Central to this Aim is an innovative, customized laboratory information management system (LIMS) in coordination with OpenSpecimen to track samples, the associated metadata, and experimental outputs. The ADM will organize regular Executive Committee meetings as an open forum for the sharing of successes, ideas and trouble shooting. The ADM will compile biannual Progress reports from each Core for evaluation by the SenNet Steering Committee and annual reports for evaluation by an Internal Advisory Board (internal to CUIMC, external to CUSTMAP). Finally, the ADM will facilitate Network Coordination, highlighted in Aim 3: Foster collaboration and integration of the CUSTMAP Center with the SenNet consortium. The ADM will collaborate with the CUSTMAP DAC and the SenNet CODCC to develop harmonious Standard Operating Practices (SOPs), Common Data Elements (CDEs) and suitable data packages and will oversee the delivery of quality data to the CODCC. The ADM will also leverage interactions with other TMCs in the SenNet consortium to optimize SOPs, assay protocols, consent materials, and data analysis, etc. The ADM will provide the seamless integration of multiple moving parts, at multiple sites, to produce high quality, meaningful data towards the SenNet goal of high-resolution atlases of senescence in diverse healthy tissues.

行政核心 (ADM)：项目摘要 管理核心（ADM）是哥伦比亚大学衰老组织的必要组成部分 测绘（CUSTMAP）中心；它将提供研究和后勤监督并促进沟通 所有中心核心以及 SenNet 联盟组织和数据协调中心 (CODCC)、整个 SenNet 联盟和 NIH。 ADM 由一名主任、所有中心 PI (MPI)、 执行委员会（所有核心领导层）和支持人员（项目经理和系统分析师）将 监督和协调三个核心的方向（生物样本核心 (BIO)、生物分析核心 （BAC）和数据分析核心（DAC））。这些核心将有助于三个主要领域的衰老研究 成人一生中的组织类型，即皮肤、大脑和脊髓。 ADM 将具有三个主要功能 支持 CUSTMAP 中心并最终支持 SenNet 联盟倡议。第一个是领导力， 目标 1 强调：提供科学的领导和治理结构，以确保一体化和 CUSTMAP 中心组成部分和活动的职能。 CUSTMAP 中心的活动将涵盖多个领域 站点（CUIMC-All Cores、爱丁堡大学-BIO、纽约基因组中心-BAC 和纽约大学- DAC），因此需要一个中央管理和组织结构。 ADM 将成为 决策、所有中心文件以及遵守道德政策。重要的是，ADM 将确保 CUSTMAP 中心的研究符合商定的标准和资源共享计划，正式 由该中心和 NIH 共同制定。第二个角色是中心协调，在目标 2：促进中强调 内部沟通并促进 CUSTMAP 中心内的协同作用。 ADM 将提供 所有 CUSTMAP 中心核心之间的协调。这一目标的核心是一个创新的、定制的实验室 信息管理系统 (LIMS) 与 OpenSpecimen 协调来跟踪样本、相关的 元数据和实验输出。 ADM 将定期组织执行委员会会议作为公开会议 分享成功、想法和解决问题的论坛。 ADM 将编制半年进度报告 每个核心由 SenNet 指导委员会进行评估，年度报告由内部评估 顾问委员会（CUIMC 内部，CUSTMAP 外部）。最后，ADM 将促进网络 目标 3 中强调的协调：促进 CUSTMAP 中心与 SenNet 联盟。 ADM 将与 CUSTMAP DAC 和 SenNet CODCC 合作开发 和谐的标准操作实践 (SOP)、通用数据元素 (CDE) 和合适的数据包 并将监督向 COCDCC 提供的质量数据。 ADM 还将利用与其他机构的互动 SenNet 联盟中的 TMC 负责优化 SOP、检测方案、同意材料和数据分析等。 ADM 将在多个地点提供多个移动部件的无缝集成，以生产高质量、 为实现 SenNet 不同健康组织衰老高分辨率图谱的目标提供有意义的数据。