Developing of a computer-based multimodal mind and body approach for mild cognitive decline

开发基于计算机的多模式身心方法来治疗轻度认知衰退

• 批准号: 10699442
• 负责人: JIAN KONG
• 金额: $ 49.81万
• 依托单位: BRAIN THRIVE TECHNOLOGY LLC
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10699442
• 关键词: Acupressure; Acupuncture Therapy; Adherence; Adult; Alzheimer' s Disease; Alzheimer' s disease pathology; Alzheimer' s disease therapy; Antiinflammatory Effect; Area; Baduanjin; Benchmarking; Breathing; Characteristics; Clinic; Clinical Research; Cognition; Cognitive; Computers; Connective Tissue; Dementia; Development; Disease; Elderly; Exercise; Feasibility Studies; Goals; Guided imagery; Hippocampus; Home; Hospitals; Impaired cognition; Individual; Instruction; Intervention; Medial; Medicine; Memory; Memory Loss; Methods; Movement; Muscle relaxation phase; Neurologic; Participant; Patients; Performance; Persons; Pharmacological Treatment; Phase; Posture; Prefrontal Cortex; Prevention; Preventive therapy; Privatization; Probability; Psyche structure; Qi; Randomized; Regulation; Relaxation Techniques; Research; Rest; Safety; Small Business Technology Transfer Research; System; Tendon structure; Testing; Time; Ventral Tegmental Area; Video Recording; Work; age related; clinical diagnosis; clinical efficacy; cognitive function; cognitive training; cost effective; design; effective therapy; gray matter; improved; innovation; locus ceruleus structure; mild cognitive impairment; mind/body; multimodality; normal aging; novel; preference; primary outcome; programs; prototype; recruit; response; satisfaction; strength training; theories; treatment effect; web site

Summary Mild cognitive impairment (MCI) represents an intermediate state between normal aging and the diagnosis of clinically probable very early Alzheimer's disease (AD). Since MCI manifests before the onset of AD, it may be the optimal stage in which to intervene with preventative therapies for AD and age-related dementia before progressive neurological loss and irreversible cognitive impairment. Nevertheless, pharmacologic treatment for MCI is far from satisfactory, highlighting the urgent need for new treatment solutions for MCI. Baduanjin (BDJ) is a unique and innovative mind-body exercise characterized by the interplay of symmetrical physical postures and movements, focusing on strengthening muscles and tendons. It consists of eight simple movements that can be easily practiced at home when guided by videos /audio. These characteristics make it a suitable option for older adults with MCI. Studies from both our group and others have demonstrated its potentials for improving cognitive function for older adults with MCI. Nevertheless, studies also showed that the response to BDJ varies significantly, some individuals demonstrate only a moderate response. To overcome the challenge, this application aims to integrate BDJ with other mind and body approaches to develop a more effective treatment option for MCI. The goal of this Phase I R41 (STTR) application is to develop a computer-based multimodal mind and body approach (cbMMBA) to improve the cognitive function for MCI. Specifically, we will first develop a functional cbMMBA platform (prototype) integrating BDJ, acupressure, and relaxation techniques (Aim 1). We chose these methods, not only because some of these methods alone have demonstrated their potential to improve cognitive function in MCI / dementia, but because they also can interact with each other positively to produce synergistic effects. Next, we will perform a feasibility study using the cbMMBA on MCI (Aim 2). This application, if successful, will provide a cost-effective and easily accessible treatment option for MCI and other age-related dementia, significantly improve the prevention of MCI development, and directly benefit patients suffering from the highly prevalent disorder, particularly for those who may have limited access to in- person mind and body interventions.

概括 轻度认知障碍（MCI）代表正常衰老和诊断为认知障碍之间的中间状态 临床上很可能是极早期阿尔茨海默病 (AD)。由于 MCI 在 AD 发病之前就已出现，因此可能 在此之前对 AD 和年龄相关性痴呆进行预防性治疗的最佳阶段 进行性神经功能丧失和不可逆的认知障碍。尽管如此，药物治疗 MCI 的情况远不能令人满意，凸显了 MCI 迫切需要新的治疗解决方案。 八段锦 (BDJ) 是一种独特且创新的身心锻炼，其特点是对称的相互作用 身体姿势和动作，重点是加强肌肉和肌腱。它由八个简单的 在视频/音频的指导下，可以在家轻松练习的动作。这些特点使其 对于患有 MCI 的老年人来说是一个合适的选择。我们小组和其他人的研究都证明了它的 改善患有 MCI 的老年人认知功能的潜力。尽管如此，研究还表明， 对 BDJ 的反应差异很大，有些人仅表现出中等反应。克服 为了应对挑战，该应用程序旨在将 BDJ 与其他身心方法相结合，以开发更多 MCI 的有效治疗选择。 第一阶段 R41 (STTR) 应用程序的目标是开发基于计算机的多模式身心 方法 (cbMMBA) 来改善 MCI 的认知功能。具体来说，我们将首先开发一个功能 cbMMBA 平台（原型）集成了 BDJ、指压按摩和放松技术（目标 1）。我们选择了 这些方法，不仅因为其中一些方法本身已经证明了它们改进的潜力 MCI/痴呆症中的认知功能，但因为它们也可以积极地相互作用以产生 协同效应。接下来，我们将利用 cbMMBA 对 MCI 进行可行性研究（目标 2）。 该应用如果成功，将为 MCI 和 其他年龄相关性痴呆，显着改善 MCI 发展的预防，直接受益 患有这种高度普遍疾病的患者，特别是那些可能无法获得足够的治疗的患者 人的身心干预。