Modulation effects of Baduanjin mind-body exercise on subjective cognitive decline

八段锦身心锻炼对主观认知下降的调节作用

• 批准号: 10224088
• 负责人: JIAN KONG
• 金额: $ 81.03万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-15 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10224088
• 关键词: Affect; Age-associated memory impairment; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease therapy; Area; Attention; Bilateral; Biological Markers; Blood Glucose; Blood Tests; Body mass index; Brain; Brain-Derived Neurotrophic Factor; Breathing; Characteristics; Clinical; Clinical assessments; Cognition; Cognitive; Complex; Dementia; Development; Disease; Elderly; Exercise; Family; Foundations; Functional disorder; Health; Health education; High Density Lipoproteins; Hippocampus (Brain); Home; Impaired cognition; Impairment; Individual; Insula of Reil; Interleukin-6; Intervention; Lobe; Low Prevalence; Low-Density Lipoproteins; Magnetic Resonance Imaging; Measurement; Measures; Medial; Memory; Memory Loss; Methods; Mind-Body Intervention; Movement; Neurobiology; Neurologic; Patient Self-Report; Patients; Perception; Performance; Pharmacologic Substance; Phase; Pilot Projects; Prefrontal Cortex; Prevention; Preventive therapy; Quality of life; Randomized; Reporting; Research; Rest; Risk Factors; Solid; Tai Ji; Tendon structure; Time; Triglycerides; Walking; active control; age related; attentional control; blood pressure reduction; body-mind; brain volume; cognitive function; cognitive testing; cooperative study; cost; cytokine; epidemiological model; executive function; exercise program; flexibility; follow-up; functional improvement; gray matter; improved; innovation; insight; mild cognitive impairment; morphometry; novel; physical conditioning; preclinical study; prevent; putamen; strength training; treatment effect

Summary Subjective cognitive decline (SCD), the self-reported perception of memory or cognitive problems, is receiving increasing attention as a risk factor for the development of Alzheimer’s disease (AD). Since SCD manifests before the onset of clinical impairment, it might be the optimal stage/window of time at which to intervene with preventative therapies for AD and age-related dementia before the progressive neurological loss and irreversible cognitive impairment. Recently, mind-body interventions have demonstrated their potential in preventing cognitive decline. Nevertheless, these mind-body therapies encompass a family of complex practices, each with different characteristics and focus. Therefore, they may be associated with different mechanisms and treatment effects. Baduanjin (BDJ) is an innovative and simple mind-body exercise consisting of eight simple movements that can be easily practiced at home with video guidance, thereby making it a more suitable option for older adults with cognitive decline than other more complex exercises. In a previous study, we found that BDJ significantly improved memory and executive function, resting state functional connectivity of the hippocampus and dorsolateral prefrontal cortex, and grey matter volume of the medial temporal area and putamen in older adults. In addition, we found that BDJ could produce significantly greater cognitive function improvement, as measured by the Wechsler Memory Scale (WMS) sub-score, and more extensive grey matter brain volume changes at medial temperal lobe and putamen. A more recent pilot study showed that, compared to walking and health education, six months of BDJ significantly improved cognitive function in patients with MCI. These findings provide a solid foundation for the current application. This proposal aims to investigate 1) the preventative effect of longitudinal BDJ on cognitive decline, 2) the modulation effect of BDJ on resting state functional connectivity of the hippocampus and bilateral dorsolateral prefrontal cortex, and 3) the modulation effect of BDJ on brain morphometry in individuals with SCD as compared to controls. We believe that this study will 1) significantly improve the prevention of MCI and AD and directly benefit patients suffering from these highly prevalent disorders, 2) enhance our understanding of the neurobiology through which mind-body interventions affect cognition and health, and 3) advance our understanding of the pathophysiology and development of SCD, AD, and age-related dementia.

概括 主观认知衰退（SCD），即自我报告的记忆或认知问题的感知，正在接受 自 SCD 出现以来，作为阿尔茨海默氏病 (AD) 发展的危险因素越来越受到关注。 在临床损伤出现之前，这可能是干预的最佳阶段/时间窗口 在进行性神经功能丧失之前对 AD 和年龄相关性痴呆进行预防性治疗 不可逆的认知障碍。 最近，身心干预已证明其在预防认知能力下降方面的潜力。 然而，这些身心疗法包含一系列复杂的实践，每一个都有不同的内容 因此，它们可能与不同的机制和治疗效果有关。 八段锦 (BDJ) 是一种创新且简单的身心锻炼，由八个简单的动作组成， 可以在家中通过视频指导轻松练习，因此更适合老年人 在之前的一项研究中，我们发现 BDJ 与其他更复杂的练习相比，认知能力下降显着。 改善记忆和执行功能、海马体的静息状态功能连接和 老年人的背外侧前额皮质、内侧颞区和壳核的灰质体积 此外，我们发现 BDJ 可以显着改善认知功能，如 通过韦氏记忆量表 (WMS) 子分数测量，以及更广泛的灰质脑容量 最近的一项初步研究表明，与步行相比，内侧颞叶和壳核发生了变化。 和健康教育方面，六个月的 BDJ 显着改善了 MCI 患者的认知功能。 研究结果为当前的应用提供了坚实的基础。 该提案旨在研究 1) 纵向 BDJ 对认知能力下降的预防作用，2) BDJ对海马和双侧背外侧静息态功能连接的调节作用 前额皮质，3) BDJ 对 SCD 个体大脑形态测量的调节作用 与对照相比，我们相信这项研究将 1) 显着改善 MCI 和 AD 的预防， 直接使患有这些高度流行疾病的患者受益，2）增强我们对这些疾病的了解 神经生物学，身心干预通过神经生物学影响认知和健康，3）促进我们的 了解 SCD、AD 和年龄相关性痴呆的病理生理学和发展。