A New Multi-functional and Connected Mobile App Guiding Acupressure Use for Self-management and Monitoring of Cancer Related Fatigue and Sleep Disturbances

一款新的多功能互联移动应用程序，指导使用穴位按摩进行自我管理和监测癌症相关的疲劳和睡眠障碍

• 批准号: 10255903
• 负责人: SUSAN L BECK
• 金额: $ 39.74万
• 依托单位: 5 POINT APP
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-16 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10255903
• 关键词: Acupressure; Acupuncture Points; Adherence; Adoption; Affect; Aftercare; American; Apple watch; Biological; Cancer Center; Cancer Fatigue; Cancer Patient; Cancer Survivor; Caregivers; Clinical; Clinical Trials; Competence; Computer Systems; Computer software; Data; Devices; Diagnosis; Distress; Dose; Effectiveness; Emotional; Evaluation; Exercise; Fatigue; Feedback; Funding; Goals; Health; Hospitals; Individual; Instruction; Insurance; Interview; Location; Mainstreaming; Malignant Neoplasms; Marketing; Measures; Medical; Mental Depression; Methods; Modification; Monitor; Nonpharmacologic Therapy; Outcome; Pain; Participant; Patient Self-Report; Patients; Performance; Phase; Protocols documentation; Provider; Quality of life; Questionnaires; Randomized Controlled Trials; Recommendation; Reporting; Research; Sampling; Science; Self Administration; Self Care; Self Management; Sleep; Sleep Deprivation; Sleep disturbances; Small Business Innovation Research Grant; Stream; Symptoms; Techniques; Testing; Time; Treatment-Related Cancer; United States National Institutes of Health; Video Recording; Volatile Oils; cancer care; cancer therapy; clinical care; commercialization; compliance behavior; cost; design; disabling symptom; efficacy evaluation; evidence base; experience; fitbit; fitness; health data; improved; instructor; mHealth; mobile application; novel; pressure; prototype; response; social; symptom treatment; usability

PROJECT SUMMARY Fatigue and sleep disturbances, common, distressing, and debilitating symptoms of cancer and its treatment, negatively impact physical, emotional, and social health of millions of cancer patients. Most of the 1.7 million Americans diagnosed with cancer in 2020 will suffer cancer and treatment-related symptoms; up to 90% receiving treatment experience fatigue; 30% may experience long-lasting fatigue. Sleep disturbances (affecting up to 75% of patients) contribute to poor health and may exacerbate fatigue. Mounting evidence indicates that acupressure, which is unfamiliar and infrequently used by cancer survivors, can reduce fatigue and improve sleep. 5 Point App, Inc. is developing its first mobile health (mHealth) software, EnergyPoints, a patient activation and educational app that offers an opportunity to mainstream acupressure—a beneficial strategy to help cancer patients self-manage their symptoms. The EnergyPoints App will motivate and guide cancer patients to implement daily acupressure protocols to self-manage fatigue and sleep disturbances. The app will connect individual sleep and activity data synced from an Apple Watch/Fitbit with self-reports of symptoms, allowing patients and clinical providers to monitor symptom response to acupressure self-treatment. The long- term goal is to improve quality of life for cancer patients suffering from fatigue and sleep disturbances using acupressure as a safe, universally affordable self-care technique. The team will first develop a fully functional prototype app, validating data accuracy and debugging programming. Specific aim 1 is to confirm cancer patients can accurately and consistently self-administer two acupressure protocols using the app. Specific aim 2 is to assess the usability of the app and the fitness tracker. Using an integrated agile, user-centered approach, 20 patients with cancer who are experiencing fatigue will use the app to self-administer acupressure (twice daily for 1 week) while wearing a fitness tracker. User performance video-recordings, and feedback via talk-aloud session, debriefing, and exit interview, will be used to improve all prototype app features in sprints. Results will provide evidence of feasibility and usability: specifically, the EnergyPoints prototype app can teach and guide cancer patients to perform acupressure as directed, is acceptable, and can connect and accurately share important health data from a fitness tracker. In a subsequent Phase 2 SBIR application, a clinical trial is planned to examine efficacy of the app in improving fatigue and sleep in a sample of cancer patients. Additionally, EnergyPoints App features will be extended by adding: 1) use of essential oils; 2) tailored acupressure delivery; 3) clinical monitoring to integrate with cancer care; 4) social connection features, 5) additional measures (e.g. pain, depression, activation) and 6) compatibility with other trackers (e.g. Amazon Halo). Potential users include millions of cancer patients before and after treatment. The initial commercialization strategy includes multiple revenue streams and marketing directed towards patients, caregivers, practitioners, cancer centers, hospitals, medical practices, and corporate sponsors.

项目概要 疲劳和睡眠障碍，癌症及其治疗的常见、令人痛苦和衰弱的症状， 对数百万癌症患者的身体、情感和社会健康产生负面影响，其中大多数是 170 万癌症患者。 2020 年被诊断患有癌症的美国人将有高达 90% 患有癌症和治疗相关症状； 接受治疗时会感到疲劳；30% 可能会出现长期疲劳（影响睡眠）。 高达 75% 的患者）会导致健康状况不佳，并可能加剧疲劳。 癌症幸存者不熟悉且不经常使用的穴位按摩可以减轻疲劳并改善 5 Point App, Inc. 正在开发其首款移动健康 (mHealth) 软件 EnergyPoints，用于患者。 激活和教育应用程序，提供了主流穴位按摩的机会——这是一种有益的策略 EnergyPoints 应用程序将帮助癌症患者自我管理症状。 该应用程序将帮助患者实施每日穴位按摩方案以自我管理疲劳和睡眠障碍。 将从 Apple Watch/Fitbit 同步的个人睡眠和活动数据与症状自我报告联系起来， 允许患者和临床提供者监测穴位按摩自我治疗的症状反应。 长期目标是使用以下方法改善患有疲劳和睡眠障碍的癌症患者的生活质量 穴位按摩作为一种安全、普遍负担得起的自我护理技术，该团队将首先开发一种功能齐全的技术。 原型应用程序，验证数据准确性和调试编程具体目标 1 是确认癌症。 患者可以使用该应用程序准确、一致地自我执行两种穴位按摩方案。 2 是使用集成的、以用户为中心的敏捷性来评估应用程序和健身追踪器的可用性。 方法，20 名感到疲劳的癌症患者将使用该应用程序进行自我穴位按摩 （每天两次，持续 1 周）同时佩戴健身追踪器的用户表现视频记录，并通过反馈。 大声交谈、汇报和离职面谈将用于改进冲刺中的所有原型应用程序功能。 结果将提供可行性和可用性的证据：具体来说，EnergyPoints 原型应用程序可以教授 指导癌症患者按指示进行穴位按摩，可接受、能连接、准确 共享来自健身追踪器的重要健康数据 在随后的第 2 阶段 SBIR 应用中，正在进行一项临床试验。 计划检查该应用程序在改善癌症患者样本的疲劳和睡眠方面的功效。 此外，EnergyPoints 应用程序功能将通过添加以下内容进行扩展：1) 精油的使用；2) 定制精油； 穴位按摩；3) 与癌症护理相结合的临床监测；4) 社交联系功能；5) 附加措施（例如疼痛、抑郁、激活）以及 6) 与其他追踪器（例如亚马逊）的兼容性 Halo) 的潜在用户包括数百万治疗前和治疗后的癌症患者。 商业化战略包括多种收入来源和针对患者的营销， 护理人员、从业人员、癌症中心、医院、医疗机构和企业赞助商。