Auricular Point Acupressure to Manage Chemotherapy Induced Neuropathy

耳穴按摩治疗化疗引起的神经病变

基本信息

批准号：
10684707
负责人：
Constance Margaret Johnson
金额：
$ 65.65万
依托单位：
UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-01 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10684707
关键词：
Acupressure Acupuncture Therapy Adherence Affect Aftercare American Society of Clinical Oncology Analgesics Anti-Inflammatory Agents Basal Ganglia Biological Markers Bortezomib Brain Cancer Patient Cancer Survivor Cells Characteristics China Clinical Clinical Trials Data Demographic Factors Dose Ear Ear Acupuncture Ecological momentary assessment Equilibrium Esthesia Ethnic Origin Europe Exercise Fatigue Fingers Functional Magnetic Resonance Imaging Functional disorder Gender Goals Hand Health Care Costs Image Inflammation Inflammatory Interferon Type II Interleukin-1 beta Interleukin-2 Interleukin-6 Intervention Late Effects Licensing Macrophage Malignant Neoplasms Measures Mediating Monitor Needles Neurons Numbness Opioid Outcome Pain Pain Threshold Pain management Participant Patient Self-Report Patients Peripheral Nervous System Pharmaceutical Preparations Physical Function Placebo Effect Placebos Plasma Platinum Provider Psychophysics Quality of life Race Randomized, Controlled Trials Recommendation Regulation Reporting Resources Self Management Sensory Sensory Thresholds Severities Signal Transduction Sleep Specificity Stimulus Survival Rate Symptoms TNF gene Taiwan Testing Time Toes Vinca Alkaloids active method afferent nerve cancer therapy chemotherapy chemotherapy induced neuropathy cognitive control cytokine design duloxetine effective therapy efficacy evaluation executive function expectation experience fall risk foot functional disability improved indexing innovation morphine equivalent neuroimaging opioid overuse opioid use pain inhibition pain perception pain relief persistent symptom primary endpoint primary outcome secondary outcome sex side effect skills smartphone application taxane tool treatment as usual

项目摘要

More than 60% cancer patients experience chemotherapy-induced neuropathy (CIN), a severe side effect of chemotherapy (including platinum drugs, vinca alkaloids, taxanes and/or bortezomib). CIN may cause treatment delays, dose reductions, or discontinuation of therapy which can affect survival rates. With improved cancer treatments and longer survival, the late effects of CIN continue to produce a significant burden in up to 50% of cancer survivors who are suffering from CIN 6 years after treatment, with a 1.8-fold increased risk of falls. CIN continues to cause significant functional disability, negatively impacts quality of life, and significantly demands high health care costs and resource use. We propose to test auricular point acupressure (APA)—a non-invasive and nonpharmacological patient managed strategy—as an innovative solution for CIN. APA is developed from auricular acupuncture, which is an invasive (using needles) and passive treatment (administered by a licensed practitioner). APA is a non-invasive and active treatment for patients with pain. It involves needleless acupuncture-like stimulation of ear points. Small seeds are taped on specific ear points by a skilled provider and patients press on the seeds to stimulate ear points three times daily, three minutes per time, for a total of nine minutes per day to achieve pain relief. APA provides pain relief within 1–2 minutes after ear stimulation and sustains pain relief for one month after a 4-week APA intervention. APA is popular in Taiwan, China, and Europe. Though its use is sparse in the U.S., a limited number of clinical trials have supported APA in pain management. This study will provide vital information to gain a comprehensive understanding of underlying mechanism of APA on CIN and provide strong impetus for including APA as part of CIN management in clinical settings.

超过 60% 的癌症患者会出现化疗引起的神经病变 (CIN)，这是化疗药物的严重副作用化疗（包括铂类药物、长春花生物碱、紫杉烷类和/或硼替佐米）可能导致 CIN。治疗延迟、剂量减少或停止治疗可能会影响生存率。随着癌症治疗方法的改进和生存期的延长，CIN 的后期影响继续产生显着的影响高达 50% 的癌症幸存者在治疗 6 年后患有 CIN，负担增加了 1.8 倍跌倒风险增加继续导致严重的功能障碍，对生活质量产生负面影响。生命，并极大地需要高昂的医疗保健费用和资源使用。我们建议测试耳穴穴位按压 (APA)——一种非侵入性且非药物治疗的患者管理策略——作为 CIN 的创新解决方案，是从耳针疗法发展而来的。是一种侵入性（使用针头）和被动治疗（由有执照的执业医师进行）。对疼痛患者进行非侵入性积极治疗，涉及无针针灸刺激。由熟练的提供者将小种子贴在特定的耳点上，然后患者按压耳点。每天用种子刺激耳穴3次，每次3分钟，每天总共9分钟实现疼痛缓解。APA 可在刺激耳朵后 1-2 分钟内缓解疼痛并持续缓解疼痛。为期 4 周的 APA 干预后一个月，APA 在台湾、中国和欧洲很受欢迎。在美国使用很少，有限数量的临床试验支持 APA 在疼痛管理中的应用。这项研究将为全面了解潜在机制提供重要信息 APA 对 CIN 的影响，并为将 APA 作为临床环境中 CIN 管理的一部分提供了强有力的推动力。