Alcohol Sensitivity and PET Derived Measures of Opioid Activity

酒精敏感性和 PET 衍生的阿片类药物活性测量

基本信息

批准号：
7925603
负责人：
Elise M Weerts
金额：
$ 67.64万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-05 至 2012-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7925603
关键词：
Affect Alcohol consumption Alcohol dependence Alcoholism Alcohols Alleles Amygdaloid structure Biological Blood Pressure Blood alcohol level measurement Brain Brain region Characteristics Complex Data Dependence Diagnosis Disease Dopamine Enrollment Etiology Future Gene Mutation General Population Genetic Genetic Variation Genotype Heart Rate Heritability Human Individual Individual Differences Knock-out Laboratories Laboratory Animals Life Measures Mediating Normal Statistical Distribution Opioid Opioid Receptor Opioid Receptor Binding Oral Administration Pathway interactions Patient Self-Report Pattern Persons Phenotype Physiological Placebos Play Population Positron-Emission Tomography Procedures Psychophysiology Rat Strains Receptor Gene Recruitment Activity Reporting Research Rewards Risk Role Single Nucleotide Polymorphism Skin Temperature System Testing Variant Ventral Striatum alcohol effect alcohol response alcohol sensitivity alcohol use disorder base carfentanil drinking drinking behavior drug of abuse endogenous opioids endophenotype genetic association genetic risk factor genetic variant interest meetings mu opioid receptors neurotransmission preclinical study problem drinker receptor receptor density response social

项目摘要

Alcohol is one olthe most commonly abused drugs in the US, with 10% of the population affected by alcohol dependence at some point in their lives. Research over the last 20 years has demonstrated that individual dIfferences in subjective responses to alcohol may influence a person's pattern of alcohol use and is a strong predictor of future alcoholproblerns. Individuals with a low response to alcohol have an Increased-risk for alcoholism, where as Individuals With a-high response to alcohol have a reduced risk for alcoholism. Mu oploid receptors are involved in modulation of drinking behaviors and have been shown to be higher in recently abstinent alcoholics when compared to healthy controls. The current application furthur investigates the relationships between differences In brain mu opioid receptors and Individual differences In subjective responses to alcohol. We will recruit healthy social drinkers who Will complete an alcohol challenge procedure and be phenotyped based on their level of response to alcohol. Subjects who show a high response and a low response to aIcohol will undergo a [C11] carfentanil PET scan toobtain MOR BP to determine if individual differences in MOR BP are related to alcohol sensitivity under controlled laboratory conditions. The results of the proposed research will increase our understanding of to the relationship between individual variability in the opioid system and subjective sensitivity to alcohol.

酒精是美国最常见的滥用药物，其中10％在生活中某个时候受酒精依赖影响的人口。研究在过去的20年中，主观的个体差异对酒精的反应可能会影响一个人的酒精使用模式，并且很强大预测未来的酒精渗透率。对酒精反应低的人患有酒精中毒的风险增加，作为对酒精的A高反应的个体酗酒的风险降低。 Mu oploid受体参与调制与健康对照相比，最近戒酒的饮酒行为已显示出更高的饮酒行为。当前的申请Furthur调查脑Mu阿片受体差异与对酒精的主观反应的个体差异。我们将招募健康将完成酒精挑战程序并表现出来的社交饮酒者根据他们对酒精的反应水平。表现出很高回应的受试者对AICOHOL的反应较低，将经历[C11] Carfentanil PET扫描 BP确定MOR BP的个体差异是否与酒精敏感性有关在受控实验室条件下。拟议研究的结果将提高我们对个人变异性之间关系的理解阿片类药物系统和对酒精的主观敏感性。