Resolving sources of heterogeneity and comorbidity in alcohol use disorder

解决酒精使用障碍的异质性和合并症的来源

• 批准号: 10783325
• 负责人: Ashley L. Watts
• 金额: $ 24.89万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-10 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10783325
• 关键词: Adopted; Alcohol consumption; Alcohol dependence; Animal Model; Award; Behavior Control; Behavioral Genetics; Biological; Brain; Consultations; Data; Data Analyses; Data Set; Dedications; Detection; Diagnosis; Diagnostic; Dimensions; Distal; Educational workshop; Equation; Etiology; Failure; Functional disorder; Future; Genetic; Genetic Heterogeneity; Genetic Techniques; Genomics; Genotype; Heterogeneity; Human; Individual Differences; Institution; Intervention; Knowledge; Manuscripts; Maps; Mentors; Mentorship; Methods; Missouri; Modeling; Modernization; Molecular Genetics; National Institute on Alcohol Abuse and Alcoholism; Neurobiology; Neurosciences; Pathway interactions; Persons; Phase; Phenotype; Postdoctoral Fellow; Preparation; Process; Prognosis; Psychopathology; Quantitative Genetics; Registries; Research; Research Activity; Research Domain Criteria; Research Personnel; Resources; Rewards; Role; Science; Scientist; Severities; Source; Specificity; Supervision; Symptoms; Syndrome; Time; Training; Training Activity; Twin Multiple Birth; Universities; Wood material; Work; addiction; alcohol misuse; alcohol research; alcohol use disorder; career; comorbidity; craving; diagnostic criteria; disease classification; genetic analysis; genetic architecture; genome wide association study; improved; incentive salience; interest; negative affect; neurobehavioral; neurobiological mechanism; person centered; precision medicine; psychologic; skills; substance use; symposium

K.220.7: PROJECT SUMMARY/ABSTRACT Training: The major objectives of the proposed K99/R00 Pathway to Independence Award are Dr. Ashley Watts’ training in alcohol research and the launching of her career as an independent scientist. As a postdoctoral research fellow in the Department of Psychological Sciences at the University of Missouri, Dr. Watts is well along the path to becoming a leading psychopathology researcher. Dr. Watts seeks training and mentoring during the K99 phase to narrow her focus to alcohol use and alcohol use disorder and gain more training in quantitative genetics and modeling. Training in AUD will emphasize on AUD nosology; modern models of addiction, including their key neurobehavioral mechanisms; and individual differences in alcohol consumption. She will attend conferences related to alcohol use/misuse, behavior genetics, and psychopathology. She will also attend behavioral and molecular genetics workshops that span from human to animal models, as well as a neuroscience workshop; each of these workshops provides hands-on training in quantitative genetic techniques. This training will greatly extend Dr. Watts’ foundational knowledge and skill set. Dr. Watts will dedicate a great deal of her time to the dissemination of findings from the proposed research through manuscript preparation and submission. The proposed mentor and co-mentor (Drs. Kenneth Sher and Andrew Heath), collaborators (Drs. Wendy Slutske, Douglas Steinley, and Phillip Wood), and consultants (Drs. John Crabbe, Arpana Agrawal, Kathleen Bucholz, Kristina Jackson, and David Watson) collectively provide expertise that is ideally suited to facilitate the successful completion of the proposed training and research activities. Furthermore, the University of Missouri is a world-class research institution with the resources necessary to facilitate successful completion of the training (K99) phase of the proposed project. K99 Phase: With supervision, Dr. Watts will conduct secondary data analysis on phenotypic and genetic heterogeneity within AUD. This work will be achieved using a combination of large-scale cross-sectional and longitudinal phenotypic and genetically informative data. She will receive training via mentorship, coursework, workshops, readings, and consultation. R00 Phase: Dr. Watts will ascertain features of AUD that are specific to alcohol use, rather than general to substance use, externalizing psychopathology, or psychopathology more broadly using phenotypic, behavior genetic, and molecular genetic analysis. Significance: Her work will ultimately target sources of heterogeneity within AUD, characterize specific AUD vulnerabilities, and inform future precision-medicine efforts, each of which are emphasized by NIAAA’s emphases on the improvement of AUD diagnosis and understanding its relations with other forms of psychopathology (NIAAA, 2017).

K.220.7：项目摘要/摘要 培训：拟议的 K99/R00 途径独立奖的主要目标是 Ashley Watts 博士的 酒精研究方面的培训以及作为一名独立科学家的职业生涯的启动。 密苏里大学心理科学系研究员瓦茨博士进展顺利 瓦茨博士在这期间寻求培训和指导，成为一名领先的精神病理学研究员。 K99 阶段将她的注意力集中在酒精使用和酒精使用障碍上，并获得更多定量方面的培训 AUD 的遗传学和建模将强调 AUD 的现代模型； 他们的主要神经行为机制；以及饮酒的个体差异。 她还将参加与酒精使用/滥用、行为遗传学和精神病理学相关的会议。 行为和分子遗传学研讨会，涵盖从人类到动物模型以及神经科学 研讨会；每个研讨会都提供定量遗传技术的实践培训。 将极大地扩展瓦茨博士的基础知识和技能。瓦茨博士将投入大量精力。 通过手稿准备和传播拟议研究的结果的时间 拟议的导师和共同导师（Kenneth Sher 博士和 Andrew Heath）、合作者（Drs. Wendy Slutske、Douglas Steinley 和 Phillip Wood）以及顾问（John Crabbe 博士、Arpana Agrawal、 Kathleen Bucholz、Kristina Jackson 和 David Watson）共同提供了非常适合的专业知识 促进拟议的培训和研究活动的成功完成。此外，大学 密苏里州是世界一流的研究机构，拥有促进成功完成所需的资源 拟议项目的培训（K99）阶段。 K99阶段：在Watts博士的监督下，将对表型和遗传进行二次数据分析 AUD 内的异质性将通过结合大规模横截面和 她将通过指导、课程作业接受培训。 研讨会、阅读和咨询。 R00 阶段：Watts 博士将确定 AUD 的特定于饮酒的特征，而不是一般的特征。 物质使用、外化精神病理学或更广泛地使用表型、行为的病理学 遗传和分子遗传分析。 意义：她的工作最终将针对澳元内部的异质性来源，描述特定澳元的特征 漏洞，并为未来的精准医疗工作提供信息，NIAAA 强调了每一项工作 强调改进 AUD 诊断并了解其与其他形式的关系 精神病理学（NIAAA，2017）。