DYNAMIC EPIDERMAL COOLING DURING 1500 S PULSED DYE LASERTREATMENT OF PORT

端口 1500 S 脉冲染料激光治疗期间的动态表皮冷却

• 批准号: 7725026
• 负责人: KRISTEN M KELLY
• 金额: $ 0.14万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7725026
• 关键词: Adverse effects; Affect; Age; Birth; Blood Vessels; Blood capillaries; Child; Color; Computer Retrieval of Information on Scientific Projects Database; Cosmetics; Cover-up; Cryosurgery; Dermabrasion; Dermal; Dermis; Development; Dyes; Electric Stimulation Therapy; Face; Family; Funding; Grant; Hemoglobin; Histologic; Incidence; Institution; Lasers; Lesion; Light; Modality; Neck; Patients; Personality Development; Physiologic pulse; Port-Wine Stain; Pulse taking; Pump; Radiation; Research; Research Personnel; Resources; Skin graft; Source; Syncope; Tattooing; Time; United States National Institutes of Health; capillary; malformation; psychologic

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A port wine stain (PWS) is a vascular malformation found in approximately 0.3% of children (1). These lesions are generally noted at birth as a faint pink macule which, as the patient ages, thickens and darkens to a red-purple color. Histologically, PWS birthmarks consist of dermal, dilated, capillary-like vessels with no endothelial proliferation (2). PWS birthmarks may be located anywhere on the body but are commonly found on the face and neck where they have serious psychological consequences. Patients are often perceived by others as "marked" which may adversely affect personality development. For this reason and because PWS birthmarks are unlikely to involute with time, patients or their families often seek treatment. Developing acceptable treatment options has been difficult. Early attempts at treatment included cosmetic cover-up, skin grafting, radiation, dermabrasion, cryosurgery, tattooing and electrotherapy but none of these modalities provided cosmetically acceptable results. The development of lasers and their ability to damage PWS blood vessels offered another treatment option. A variety of lasers have been utilized for the treatment of PWS birthmarks but the flashlamp-pumped pulsed dye laser (FLPDL) has offered the best results with the lowest incidence of side effects. The yellow light produced by the FLPDL is preferentially absorbed by hemoglobin allowing more selective destruction of the ectatic capillaries in the dermis.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 鲜红斑痣 (PWS) 是一种血管畸形，约 0.3% 的儿童存在 (1)。这些病变通常在出生时表现为淡粉色斑疹，随着患者年龄的增长，斑疹会变厚并变暗，变成红紫色。从组织学上看，PWS 胎记由真皮扩张的毛细血管样血管组成，无内皮增殖 (2)。 PWS 胎记可能位于身体的任何部位，但常见于面部和颈部，会造成严重的心理后果。 患者常常被其他人认为是“有标记的”，这可能会对人格发展产生不利影响。 由于这个原因，并且 PWS 胎记不太可能随着时间的推移而消失，患者或其家人经常寻求治疗。 制定可接受的治疗方案一直很困难。 早期的治疗尝试包括美容遮盖、植皮、放射、磨皮、冷冻手术、纹身和电疗，但这些方法都没有提供美容上可接受的结果。 激光的发展及其破坏 PWS 血管的能力提供了另一种治疗选择。 有多种激光用于治疗 PWS 胎记，但闪光灯泵浦脉冲染料激光 (FLDDL) 提供了最佳效果，且副作用发生率最低。 FLPDL 产生的黄光优先被血红蛋白吸收，从而更有选择性地破坏真皮中扩张的毛细血管。