Photodynamic and Photothermal Port Wine Stain Treatment

光动力和光热波特酒色斑处理

基本信息

批准号：
7049591
负责人：
KRISTEN M KELLY
金额：
$ 7.45万
依托单位：
UNIVERSITY OF CALIFORNIA-IRVINE
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-07-01 至 2008-03-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Port wine stains (PWS) are congenital, progressive vascular malformations of the skin that occur in approximately 0.7% of neonates and have potentially devastating psychological complications and, in some cases, serious physical effects as well. Current therapies achieve complete blanching of less than 10% of these lesions and multiple treatments (5 -30 or more) are generally required. We intend to combine photodynamic (PDT) and pulsed dye laser (PDL) therapies (PDT + PDL) to achieve permanent destruction of the most clinically relevant PWS blood vessels without injury to the surrounding skin. We will use a vascular specific photosensitizer, benzoporphyrin derivitive monoacid ring A (BPD), and continuous wave (CW) yellow light to confine PDT effects to the most superficial 1.0 mm below the skin surface. Vascular flow will be monitored during PDT using optical Doppler tomography (ODT). CW irradiation will be stopped when a reduction in blood flow is noted or after a light dose of 100 J/cm2 has been delivered. This approach will limit the depth and extent of vascular injury to the targeted vessels and prevent skin necrosis, which would result from total vascular destruction. PDT will be followed immediately, or after a brief time interval, by PDL irradiation to complete superficial vessel destruction without injury to the surrounding skin. Initial experiments using a chick chorioallantoic membrane confirmed the superior efficacy of PDT + PDL PWS vessel destruction as compared to either modality alone. This proposal includes a protocol to confirm the superior efficacy of PDT + PDL using a rat dorsal skin flap window model. The threshold of vascular lesion damage for PDT using BPD and yellow light and optimal treatment parameters for PDT + PDL vascular therapy will also be evaluated using the same animal model. Finally, we will determine the efficacy and safety of PDT + PDL PWS therapy in comprehensive clinical trials. The results of the studies in this proposal are expected to lead to the development of novel and innovative technology which will provide a more effective and, most importantly, safer method for removal of PWS birthmarks.

描述（由申请人提供）：港口葡萄酒污渍（PWS）是先天性的，进行性血管畸形的皮肤，大约0.7％的新生儿发生，并且可能具有毁灭性的心理并发症，在某些情况下也具有严重的身体影响。当前的疗法通常需要少于10％的病变，并且通常需要多种疗法（5-30或更多）。我们打算将光动力学（PDT）和脉冲染料激光（PDL）疗法（PDT + PDL）结合起来，以实现对最临床相关的PWS血管的永久破坏，而不会伤害周围皮肤。我们将使用血管特异性光敏剂，苯二甲状腺衍生物单酸环A（BPD），并连续波（CW）黄光将PDT效应限制在皮肤表面以下最表层的1.0 mm处。使用光学多普勒断层扫描（ODT）在PDT期间将监测血管流量。当注意到血液流量减少或输送100 j/cm2的轻剂量后，将停止CW辐射。这种方法将限制靶血管损伤的深度和程度，并防止皮肤坏死，这将导致全血管破坏。 PDT将立即遵循PDT，或者在短时间间隔后通过PDL照射，以完全破坏浅表血管，而不会损伤周围皮肤。使用鸡绒毛膜膜的初步实验证实了与单独的两种方式相比，PDT + PDL PWS血管破坏的优势疗效。该提案包括使用大鼠背皮窗户模型确认PDT + PDL的出色功效的方案。使用BPD和黄光和PDT + PDL血管疗法的最佳治疗参数对PDT的血管病变损伤的阈值也将使用相同的动物模型进行评估。最后，我们将确定PDT + PDL PWS治疗在综合临床试验中的功效和安全性。预计该提案中的研究结果将导致新颖和创新的技术的发展，这将为删除PWS胎记的更有效，最重要的方法提供更有效，最重要的方法。

项目成果

期刊论文数量（2）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Enhanced port-wine stain lightening achieved with combined treatment of selective photothermolysis and imiquimod.

DOI：
10.1016/j.jaad.2011.11.958
发表时间：
2012-04
期刊：
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
影响因子：
13.8
作者：
Tremaine, Anne Marie;Armstrong, Jennifer;Huang, Yu-Chih;Elkeeb, Leila;Ortiz, Arisa;Harris, Ronald;Choi, Bernard;Kelly, Kristen M.
通讯作者：
Kelly, Kristen M.

Current Treatment Options for Port Wine Stain Birthmarks.