Multiwavelength diode laser system for PDT

用于 PDT 的多波长二极管激光系统

• 批准号: 7795216
• 负责人: KRISTEN M KELLY
• 金额: $ 45.11万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-16 至 2011-06-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7795216
• 关键词: Asia; Biomedical Technology; California; Communities; Diagnostic; Europe; Feasibility Studies; Foundations; Funding; Housing; Institutes; Lasers; Light; Medical; Patients; Photochemotherapy; Research; Research Personnel; Research Project Grants; Research Support; Resources; Science; Source; System; Technology; Therapeutic; Translating; Translations; United States; United States National Institutes of Health; Universities; base; clinical application; instrument; instrumentation; programs; supported housing; technology development; tool; user-friendly

DESCRIPTION (provided by applicant): We are a group of 10 multi-disciplinary investigators representing 6 departments at the University of California, Irvine with 11 federally funded research grants impacted by this request for instrumentation. We are seeking funds for a multi-wavelength photodynamic therapy (PDT) continuous wave light source to be housed and supported within the well-established NIH-NCRR Biomedical Technology Resource Center (P41-RR01192, Laser Microbeam and Medical Program, LAMMP) at the Beckman Laser Institute. The LAMMP facility is dedicated to defining and understanding broad issues related to the use of light as a diagnostic and therapeutic tool. BLI has been involved in developing, advancing and translating PDT science since the early 1980's and our center has a very strong foundation in technology development. There is an urgent need for a commercial, user-friendly multi-wavelength PDT light source to be housed and managed within our NIH resource. There are very few centers in the United States capable of performing the projects described in this proposal. PDT science is much more advanced in Europe and Asia. The proposed projects were initiated as pilot/feasibility studies using obsolete light sources limiting translation of the PDT science to clinical application. There is a critical need at our center to upgrade and utilize commercially available technology to support this research and to translate our technologies for patient use. Continued progress for these NIH-funded investigators is hampered without access to such an instrument. It is expected that the requested instrumentation will have a significant overall benefit to the UC Irvine research community and beyond, based on the existing strong impact of the LAMMP and its dissemination of new discoveries to colleagues and collaborators.

描述（由申请人提供）：我们是一个由 10 名多学科研究人员组成的小组，代表加州大学欧文分校的 6 个系，拥有 11 项联邦资助的研究经费，受此仪器请求的影响。我们正在为多波长光动力治疗 (PDT) 连续波光源寻求资金，该光源将在完善的 NIH-NCRR 生物医学技术资源中心（P41-RR01192，激光微束和医疗计划，LAMMP）内安置和支持。贝克曼激光研究所。 LAMMP 设施致力于定义和理解与使用光作为诊断和治疗工具相关的广泛问题。自 1980 年代初以来，BLI 一直致力于开发、推进和转化 PDT 科学，我们中心在技术开发方面拥有非常坚实的基础。迫切需要在我们的 NIH 资源中容纳和管理商业的、用户友好的多波长 PDT 光源。美国很少有中心能够执行本提案中描述的项目。 PDT 科学在欧洲和亚洲要先进得多。拟议的项目是作为试点/可行性研究而启动的，使用过时的光源限制了 PDT 科学向临床应用的转化。我们中心迫切需要升级和利用商用技术来支持这项研究并将我们的技术转化为患者使用。如果无法使用这样的仪器，这些 NIH 资助的研究人员的持续进展就会受到阻碍。基于 LAMMP 现有的强大影响及其向同事和合作者传播新发现，预计所需的仪器将为加州大学欧文分校研究界及其他地区带来重大的整体利益。