Multiwavelength diode laser system for PDT

用于 PDT 的多波长二极管激光系统

• 批准号: 7795216
• 负责人: KRISTEN M KELLY
• 金额: $ 45.11万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-16 至 2011-06-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7795216
• 关键词: Asia; Biomedical Technology; California; Communities; Diagnostic; Europe; Feasibility Studies; Foundations; Funding; Housing; Institutes; Lasers; Light; Medical; Patients; Photochemotherapy; Research; Research Personnel; Research Project Grants; Research Support; Resources; Science; Source; System; Technology; Therapeutic; Translating; Translations; United States; United States National Institutes of Health; Universities; base; clinical application; instrument; instrumentation; programs; supported housing; technology development; tool; user-friendly

DESCRIPTION (provided by applicant): We are a group of 10 multi-disciplinary investigators representing 6 departments at the University of California, Irvine with 11 federally funded research grants impacted by this request for instrumentation. We are seeking funds for a multi-wavelength photodynamic therapy (PDT) continuous wave light source to be housed and supported within the well-established NIH-NCRR Biomedical Technology Resource Center (P41-RR01192, Laser Microbeam and Medical Program, LAMMP) at the Beckman Laser Institute. The LAMMP facility is dedicated to defining and understanding broad issues related to the use of light as a diagnostic and therapeutic tool. BLI has been involved in developing, advancing and translating PDT science since the early 1980's and our center has a very strong foundation in technology development. There is an urgent need for a commercial, user-friendly multi-wavelength PDT light source to be housed and managed within our NIH resource. There are very few centers in the United States capable of performing the projects described in this proposal. PDT science is much more advanced in Europe and Asia. The proposed projects were initiated as pilot/feasibility studies using obsolete light sources limiting translation of the PDT science to clinical application. There is a critical need at our center to upgrade and utilize commercially available technology to support this research and to translate our technologies for patient use. Continued progress for these NIH-funded investigators is hampered without access to such an instrument. It is expected that the requested instrumentation will have a significant overall benefit to the UC Irvine research community and beyond, based on the existing strong impact of the LAMMP and its dissemination of new discoveries to colleagues and collaborators.

描述（由申请人提供）：我们是一组由10个多学科研究人员组成的小组，代表加利福尼亚大学尔湾分校的6个部门，其中11项联邦政府资助的研究补助金受这项仪器请求影响。我们正在为贝克曼·拉瑟学院（Beckman Laser Institute）的多波长光动力疗法（PDT）连续波源提供资金（PDT）连续的波光源（P41-RRRR01192，Laser Microbeam and Medical Program，LAMMP，LAMMP）。 LAMMP设施致力于定义和理解与使用光作为诊断和治疗工具有关的广泛问题。自1980年代初以来，BLI一直参与开发，推进和翻译PDT科学，我们的中心在技术开发方面具有非常强大的基础。迫切需要在我们的NIH资源中容纳和管理商业，用户友好的多波长PDT光源。在美国，很少有能力执行本提案中描述的项目。 PDT科学在欧洲和亚洲要高得多。拟议的项目是使用过时的光源限制了PDT科学对临床应用的转换的试点/可行性研究的。我们中心有一个迫切需要升级并利用市售技术来支持这项研究并将我们的技术转换为患者的技术。这些由NIH资助的调查人员的持续进展受到阻碍，而无需使用这种工具。预计所要求的仪器将根据LAMMP的现有强烈影响及其对同事和合作者的新发现的强烈影响，对UC Irvine Research社区及其他地区有重大利益。